Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatric Patients

Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatric Patients Undergoing Colorectal Cancer Surgery

After obtaining ethical approval, 42 patients with American Society of Anesthesiologists (ASA) scores I-III who were scheduled for surgery under general anesthesia were included in our prospective study. Patients were monitored in the preoperative preparation room in the operating room and frailty was assessed using the FRAIL scale and sarcopenia was assessed using the STAR ratio. The thickness of the rectus femoris and vastus intermedius muscles of the patients was measured and recorded by ultrasonography. Thigh lengths were measured and recorded. Rectus Femoris/Thigh Length (RF/B), Vastus Intermedius/Thigh Length (VI/B), and Total Muscle Thickness/Thigh Length (T/B) were calculated and recorded. Patients were followed up according to the Modified Aldrete Score after surgery in the anesthesia recovery unit, and the time to reach 9-10 points was recorded, and the time to leave the recovery unit was recorded. Postoperatively, complications were followed up according to the Clavien-Dindo Classification, and discharge times from the hospital were recorded.

Study Overview

• Status: Completed
• Conditions: Frailty; Sarcopenia
• Intervention / Treatment: Device: ultrasonography

Detailed Description

Frailty is a clinically identifiable state of heightened vulnerability resulting from age-related declines in physiological systems and functions, leading to impaired resilience to stressors. Frailty is highly prevalent among the elderly and is associated with an increased risk of falls, disability, hospitalization, and mortality. Magnetic resonance imaging (MRI) and computed tomography (CT) are considered the gold standard for sarcopenia diagnosisCT is also limited due to radiation exposure and similar logistical constraints. In contrast, ultrasonography (USG) is portable, cost-effective, and can be performed at the bedside without radiation exposure.

Using high-frequency ultrasound probes, peripheral muscle tissues and their dimensions can be rapidly assessed.

• Study Type: Observational
• Enrollment (Actual): 42

Contacts and Locations

Study Locations

• Turkey
  • Odunpazarı
    • Eski̇şehi̇r, Odunpazarı, Turkey, 26040
      • University of Eskisehir Osmangazi

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

42 patients over 60 years of age with ASA score I-III who were to undergo colorectal malignancy surgery under general anesthesia

Description

Inclusion Criteria:

• patients over 60 years of age who are undergoing colorectal malignancy surgery under general anesthesia
• patients willing to participate in the study
• Patients with ASA score I-III

Exclusion Criteria:

• Patients with Parkinson's disease,
• Alzheimer's disease,
• history of cerebrovascular events,
• neuromuscular disease,
• cognitive dysfunction,
• severe liver disease,
• severe heart disease,
• impaired cooperation due to kidney disease,
• emergency and trauma patients,
• patients with bilateral lower extremity amputations

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
age	years old	1 year
sex	female, male	1 year
height	meter	1 year
body weight	kg	1. year
educational status	primary school graduate, middle school graduate, high school graduate, university graduate	1 year
marital status	married, single, widowed	1 year
rectus femoris muscle thickness	cm	1 year
vastus intermedius(VI) thickness	cm	1 year
rectus femoris-to-thigh length ratio	ratio	1 year
vastus intermedius-thigh length ratio	ratio	1 year
total muscle thickness to thigh length ratio	ratio	1 year
frailty score	0-NORMAL, 1-2 PRE-FRAİL, 3-5 FRAİL	1 year
recovery time from anesthesia	minutes	1 year
hospital discharge time	days	1 year
Modified Clavien-Dindo Classification	1, 2, 3A, 3B, 4A, 4B, 5	1 year
ASA score	American Society of Anesthesiologists' Classification (ASA 1,2,3,4,5)	1 year

Collaborators and Investigators

• Sponsor: Eskisehir Osmangazi University
• Investigators: Principal Investigator: ferda yaman, Assoc prof, University of Eskisehir Osmangazi

Study record dates

Study Major Dates

• Study Start (Actual): July 20, 2023
• Primary Completion (Actual): July 20, 2024
• Study Completion (Actual): July 20, 2024

Study Registration Dates

• First Submitted: March 17, 2025
• First Submitted That Met QC Criteria: March 17, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 27, 2025
• Last Update Submitted That Met QC Criteria: March 24, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Keywords: sarcopenia; ultrasonography; geriatric anesthesia; postoperative complications; quadriceps femoris
• Additional Relevant MeSH Terms: Neurologic Manifestations; Nervous System Diseases; Neuromuscular Manifestations; Pathologic Processes; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Frailty; Sarcopenia
• Other Study ID Numbers: Eskisehir

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No