Outcomes of Critically Ill Patients Undergoing RRT- a Registry Based Study.

April 11, 2025 updated by: Bipin Karki, Tribhuvan University Teaching Hospital, Institute Of Medicine.

Outcomes of Acute Kidney Injury Requiring Renal Replacement Therapy in a Tertiary Level Teaching Hospital in Nepal: a Registry Based Retrospective Study

Rationale: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is a frequently occurring entity among critically ill patients. This study aims to determine the outcomes of patients undergoing renal replacement therapy in the ICU.

Study Objective: To find the outcomes of patients undergoing RRT in the ICU in terms of mortality and length of ICU stay.

Design: A registry based, retrospective, descriptive study. Sample size: Convenience sampling of all the patients who require RRT during the ICU stay.

Duration: Retrospective data from three years January 1, 2020 to December 30, 2023.

Place: Intensive care units (ICUs) of the Department of Critical Care Medicine, Tribhuvan University Teaching Hospital (TUTH).

Interventions: Not applicable Expected results: The study will help determine the outcomes of the critically ill patients undergoing RRT in a low middle income country ICU.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

516

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Nepal
    • Bagmati
      • Maharajganj, Bagmati, Nepal, 44600
        • Tribhuvan University Teaching Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

All patients admitted to the ICU requiring renal replacement therapy

Description

Inclusion Criteria:

  • Age>18 years
  • Admission to the ICU
  • All patients undergoing RRT during ICU stay

Exclusion Criteria:

  • None

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
RRT
Patients undergoing renal replacement therapy
NRRT
Patients not undergoing renal replacement therapy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
ICU mortality
Time Frame: A the end of 3 years
A the end of 3 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Treatment limitations
Time Frame: At the end of 3 years
Patients who receiving treatment limitation orders (Leave against medical advice, do not resuscitate/do not intubate, withdrawal of treatment orders)
At the end of 3 years

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
LOS-ICU
Time Frame: At the end of 3 years
Number of days admitted to the ICU
At the end of 3 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tribhuvan University Teaching Hospital, Institute Of Medicine.

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2020

Primary Completion (Actual)

December 31, 2022

Study Completion (Actual)

December 31, 2022

Study Registration Dates

First Submitted

March 16, 2025

First Submitted That Met QC Criteria

March 20, 2025

First Posted (Actual)

March 26, 2025

Study Record Updates

Last Update Posted (Actual)

April 16, 2025

Last Update Submitted That Met QC Criteria

April 11, 2025

Last Verified

April 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 518(6-11)E2-079/080

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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