The Effect of Salpingectomy Operation on Ovarian Reserve

Evaluation of the Effect of Salpingectomy Operation on Ovarian Reserve With Anti-Mullerian Hormone and Ovarian Doppler Ultrasonography

This study aimed to evaluate the effect of salpingectomy operation on ovarian reserve. Ovarian reserve was evaluated by measuring anti-mullerian hormone levels from serum samples taken from the patients before the operation and 6 weeks after the operation. Ovarian doppler flow were evaluated by measuring the ovarian artery pulsatility index with transvaginal ultrasonography preoperatively, postoperative days 2 and postoperative weeks 6 . In our study, it was determined that ovarian functions may be negatively affected in the acute period after salpingectomy operation.

Study Overview

• Status: Completed
• Conditions: Ovarian Insufficiency
• Intervention / Treatment: Procedure: bilateral salpingectomy, ovarian arter doppler ultrasonography

• Study Type: Observational
• Enrollment (Actual): 31

Contacts and Locations

Study Locations

• Turkey
  • İzmir, Turkey, 35000
    • Dokuz Eylul University School of Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Serum samples will be separated from routine blood samples taken from patients who apply to the outpatient clinic and will undergo salpingectomy within the indication, during perioperative preparation and at the 6th week postoperatively, after patient consent is obtained. This serum sample will be taken into an Eppendorf tube and kept at -40˚C for later AMH levels to be studied. Ovarian artery pulsatility index values measured during the patient's perioperative and postoperative routine ultrasonographic examination and weeks 6 postoperative control will be recorded.

Description

Inclusion Criteria:

1. Women between the ages of 37-45 with continuing menstrual cycles (37 and 45 included)
2. Patients who will undergo uterine surgery for benign reasons or who will undergo salpingectomy only due to hydrosalpinx, ectopic pregnancy, tubo-ovarian abscess
3. Patients who have not had ovarian surgery before
4. Those without menopause and premature ovarian failure
5. Patients who accept the study

Exclusion Criteria:

1. Age younger than 37 or older than 45
2. Those who want to withdraw from the study
3. Those who do not come for follow-up examination
4. Use of drugs that affect ovarian reserve
5. Any surgical procedure performed on the ovaries during the operation
6. No menstrual bleeding in the last year
7. Patients who received radiotherapy and hormonal therapy within 3 months before surgery

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
perioperative ovarian arter pulsatility index(PI)(right and left), perioperative AMH levels	Procedure: bilateral salpingectomy, ovarian arter doppler ultrasonography; The effect of salpingectomy operation on ovarian reserve
postoperative days 2 ovarian arter pulsatility index (PI) (right and left)	Procedure: bilateral salpingectomy, ovarian arter doppler ultrasonography; The effect of salpingectomy operation on ovarian reserve
postop. weeks 6 ovarian arter pulsatility index(PI)(right and left), postop. weeks 6 AMH levels	Procedure: bilateral salpingectomy, ovarian arter doppler ultrasonography; The effect of salpingectomy operation on ovarian reserve

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
right ovarian arter pı	rate of 0,87/ 0,84/ 0,76	perioperative, postoperative days 2 , postoperative weeks 6
left ovarian arter pı	rate of 0,89/ 0,79/ 0.80	perioperative, postoperative days 2, postoperative weeks 6
AMH levels	Concentration of 1 ng/mL / 0,79 ng/mL	perioperative-postoperative weeks 6

Collaborators and Investigators

• Sponsor: Dokuz Eylul University

Study record dates

Study Major Dates

• Study Start (Actual): October 27, 2020
• Primary Completion (Actual): March 3, 2021
• Study Completion (Actual): June 5, 2021

Study Registration Dates

• First Submitted: March 21, 2025
• First Submitted That Met QC Criteria: March 28, 2025
• First Posted (Actual): March 31, 2025

Study Record Updates

• Last Update Posted (Actual): April 3, 2025
• Last Update Submitted That Met QC Criteria: March 31, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Keywords: Salpingectomy; Ovarian Reserve; Anti-Mullerian Hormone; Doppler Ultrasonography
• Other Study ID Numbers: SOORAMHODU

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No