Effects of High Functional Resistance Training Program on Arterial Stiffness

April 16, 2025 updated by: Timothy Werner, Salisbury University

Effects of an 11-Week High Functional Resistance Training Program on Indices of Arterial Stiffness

Study examined the effects of CrossFit training on blood vessels. The results indicate long term CrossFit training does not harm blood vessel function.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Arterial stiffness is a systemic loss of elastic properties that significantly augment cardiovascular disease risk in adults. Chronic aerobic and anaerobic exercise activity has consistently been shown to attenuate or not affect markers of arterial stiffness in adults with chronic disease and otherwise healthy adults. Chronic high functional resistance training's effect on vascular compliance is less understood. The study aimed to determine the impact of a chronic high functional resistance training program on pulse wave velocity and beta-stiffness index. Accordingly, participants (18-40 years old) were placed in a non-randomized fashion into high functional resistance training (HIB) group (n = 9; >6 months of CrossFit experience; 4 female) or control (CON) group (n = 8; < 6 months of exercise experience; 6 female). Participants in the HIB group trained at the same local facility 4 -5 days a week, utilizing the same training program. CON group refrained from exercise during the study period. Body composition, 1,000-meter rowing test, deadlift 1 repetition maximum (1 RM), hemodynamic assessments, and vascular compliance were assessed at baseline and follow-up.

Study Type

Interventional

Enrollment (Actual)

17

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Maryland
      • Salisbury, Maryland, United States, 21801
        • Salisbury University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • body weight stability with no more than ± 2.5 kg fluctuations in last six month

Exclusion Criteria:

  • hypertension
  • heart disease
  • cancer
  • diabetes
  • renal disease
  • hepatic disorders
  • history of tobacco use.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Control Group
Other: Control
Did not participate in exercise related activities for the duration of the study period.
Experimental: Exercise Group
Other: Exercise
The exercise group performed an 11-week high-functional resistance program in a group training format. They trained 3-4 days a week following nationally assigned workouts

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Pulse wave velocity
Time Frame: From enrollment to the end of treatment at 11 weeks
From enrollment to the end of treatment at 11 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Salisbury University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 29, 2020

Primary Completion (Actual)

December 10, 2023

Study Completion (Actual)

January 15, 2024

Study Registration Dates

First Submitted

April 10, 2025

First Submitted That Met QC Criteria

April 16, 2025

First Posted (Actual)

April 20, 2025

Study Record Updates

Last Update Posted (Actual)

April 20, 2025

Last Update Submitted That Met QC Criteria

April 16, 2025

Last Verified

April 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • #1

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Data will be shared upon request.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • ANALYTIC_CODE

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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