Impact of Previous Open Renal Surgery on Percutaneous Nephrolithotomy Complications

July 24, 2025 updated by: Ahmed Mahmoud Reyad, Sohag University

The Impact of Previous Open Renal Surgery on Percutaneous Nephrolithotomy Complications

This study compared percutaneous nephrolithotomy (PCNL) complications in cases with or without previous renal surgery.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Percutaneous nephrolithotomy (PCNL) is a cornerstone in managing large renal calculi. However, in patients with a history of previous open renal surgery (POS), retroperitoneal scarring, altered anatomy, and vascular complications may influence PCNL outcomes.

The literature remains inconsistent regarding whether POS negatively impacts PCNL success or increases complications. Therefore, this study aims to clarify the comparative safety and efficacy of PCNL in patients with and without prior open renal surgery.

Study Type

Observational

Enrollment (Actual)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Sohag, Egypt, 82511
        • Sohag University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

This prospective hospital-based comparative study included 200 patients with recurrent renal stones in one arm and an equal number of patients in a control arm.

Description

Inclusion Criteria:

  • Adult patients (≥18 years).
  • Both sexes.
  • Undergoing percutaneous nephrolithotomy (PCNL) for renal calculi >2 cm.

Exclusion Criteria:

  • Active urinary tract infection.
  • Elevated serum creatinine >2.0 mg/dL.
  • Pregnancy.
  • Uncontrolled coagulopathy.
  • Significant cardiopulmonary comorbidities.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Fresh cases
Patients with no prior renal surgery.
Procedure: Percutaneous Nephrolithotomy
Patients underwent percutaneous nephrolithotomy (PCNL) for renal calculi >2 cm.
Recurrent cases
Patients with previous open renal surgery on the same side.
Procedure: Percutaneous Nephrolithotomy
Patients underwent percutaneous nephrolithotomy (PCNL) for renal calculi >2 cm.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Hospital stay duration
Time Frame: Till the discharge from hospital (Up to two weeks)
Lenght of hospital stay was recorded from the admission till the discharge from hospital.
Till the discharge from hospital (Up to two weeks)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Serum creatinine level
Time Frame: Preoperatively
Serum creatinine level was recorded.
Preoperatively
Incidence of patients who need for auxiliary procedure
Time Frame: 24 hours postoperatively
Incidence of patients who need for auxiliary procedure were recorded.
24 hours postoperatively

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sohag University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2017

Primary Completion (Actual)

August 1, 2020

Study Completion (Actual)

August 1, 2020

Study Registration Dates

First Submitted

July 24, 2025

First Submitted That Met QC Criteria

July 24, 2025

First Posted (Actual)

July 31, 2025

Study Record Updates

Last Update Posted (Actual)

July 31, 2025

Last Update Submitted That Met QC Criteria

July 24, 2025

Last Verified

July 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • Soh-Med-25-6-1PD

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

The data will be available upon a reasonable request from the corresponding author after the end of study for one year.

IPD Sharing Time Frame

After the end of study for one year.

IPD Sharing Access Criteria

The data will be available upon a reasonable request from the corresponding author.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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