Evaluation of a Herbal Antiseptic Gel as a Supportive Treatment for Teeth Cleaning in Patients With Periodontal Disease

August 14, 2025 updated by: Karthik Krishna M, Rungta College of Dental Sciences and Research

Evaluation of Thermoreversible Avocado-based Gel as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients: A Clinical And Microbiological Study

The goal of this clinical trial is to learn if the herbal gel is more effective as compared to placebo in reducing periodontal inflammation in patients with periodontal disease.

The clinicians shall check various periodontal parameters in the subjects over a scheduled duration.

Participants will be administered the gel once subgingivally and the periodontal parameters shall be recorded before gel delivery then again after 1,3 and 6 months.

Plaque samples were taken at baseline and 6 months

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Chronic periodontitis is a prevalent inflammatory condition primarily caused by bacterial plaque biofilm, leading to progressive attachment and bone loss. Scaling and root planing (SRP) is the gold standard for its management. Recently, natural and herbal-based adjuncts have gained attention for their antimicrobial and anti-inflammatory properties. This study aimed to evaluate the clinical and microbiological effectiveness of 4% avocado gel as an adjunct to SRP in the treatment of chronic periodontitis.

A randomized controlled clinical trial was conducted on patients diagnosed with chronic periodontitis. Subjects were divided into two groups: Group I received SRP with subgingival application of placebo gel, and Group II received SRP along with subgingival application of 4% avocado gel. Clinical parameters, including Plaque Index (PI), Papilla Bleeding Index (PBI), Probing Pocket Depth (PPD), and Relative Attachment Level (RAL), were recorded at baseline and after 4th week and 12th week. Microbiological analysis was conducted at recorded at baseline, 4th week,12th week and 24th week to assess the presence of Porphyromonas gingivalis and Prevotella intermedia using culture methods.

Study Type

Interventional

Enrollment (Actual)

50

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • India
    • Chhattisgarh
      • Durg, Chhattisgarh, India, 490024
        • Rungta College of Dental Sciences and Research

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria: 1. Patients with Chronic periodontitis having periodontal pockets (non-adjacent sites) of >5mm

Exclusion Criteria:

  • history of any systemic disease, Antibiotic treatment during the 6 months period prior to the study, Pregnant and lactating woman, Periodontal treatment during the previous 3 months, Severe caries or extensive restoration on the objective teeth.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: scaling and root planing with subgingival application of placebo gel
scaling and root planing of the entire dentition followed by subgingival application of placebo gel in selected site
Drug: placebo gel
local drug delivery of placebo gel
Experimental: scaling and root planing with subgingival application of thermoreversible herbal gel
scaling and root planing of the entire dentition followed by subgingival application of herbal gel in selected site
Drug: herbal drug
local drug delivery of herbal gel

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Plaque Index
Time Frame: 3 months
3 months
Papilla Bleeding Index
Time Frame: 3 months
3 months
Probing Pocket Depth
Time Frame: 3 months
3 months
Relative Attachment Level
Time Frame: 3 months
3 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
CFUs
Time Frame: 6 months
Colony Forming Units
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Rungta College of Dental Sciences and Research

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 30, 2023

Primary Completion (Actual)

March 30, 2025

Study Completion (Actual)

May 30, 2025

Study Registration Dates

First Submitted

August 14, 2025

First Submitted That Met QC Criteria

August 14, 2025

First Posted (Actual)

August 22, 2025

Study Record Updates

Last Update Posted (Actual)

August 22, 2025

Last Update Submitted That Met QC Criteria

August 14, 2025

Last Verified

July 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RCDSR/IEC/MDS/2023/D-37

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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