Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy

February 25, 2026 updated by: Michael Saminsky, Tel Aviv University

Evaluation of the Effect of Adjunctive Diode Laser Therapy in Mechanical Scaling and Root Surface Debridement in Non-Surgical Periodontal Therapy

The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office. The main question it aims to answer is:

To compare the clinical effectiveness of adjunctive application of a 940-nm diode laser with root surface debridement to the effectiveness of root surface debridement alone.

This study is a split-mouth design, where each quadrant will be randomly allocated to one of the following groups:

Control group (root surface debridement - RsD): scaling and root planing alone. Laser group (RsD + laser): scaling and root planing with adjunctive diode laser therapy Quadrants will be randomly allocated to the treatment groups

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Israel
    • North
      • Afula, North, Israel, 1839203
        • Recruiting
        • Dr Younis Mahmoud
        • Contact:
        • Contact:
        • Principal Investigator:
          • Michael Saminsky, DMD
        • Principal Investigator:
          • Mahmoud Younis, DMD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. Systemically healthy patients
  2. Each patient should have more than 20 teeth remaining, and at least 5 teeth per quadrant
  3. Each patient presented ≥ 30% of sites involved
  4. At least 2 teeth with a probing depth of ≥ 5 mm in each quadrant, with evident radiographic bone loss.

Exclusion Criteria:

  1. History of systemic diseases affecting the periodontium
  2. Smokers and alcoholic patients
  3. Use of medication within the last 6 months, which might affect the periodontal status
  4. Pregnant and lactating women
  5. Patients who had any periodontal treatment ≤ 12 months before the examination.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: test quadrants
two contralateral jaw quadrants in each patient mouth will undergo RsD and Laser Diode assisted SRP treatment
Device: LASER assisted SRP
Two quadrants will be treated mechanically (ScR) with adjunctive diode laser and another two quadrants mechanically (ScR) only
Active Comparator: control quadrants
two contralateral jaw quadrants in each patient mouth (same patient cohort) will undergo RsD treatment only
Device: RsD
mechanical root surface debridement with periodontal curettes

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
PPD
Time Frame: prior to treatment and 12 weeks and 6 months after treatment
periodontal pocket depth
prior to treatment and 12 weeks and 6 months after treatment

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
CAL
Time Frame: prior to treatment and 12 weeks and 6 months after the treatment
clinical attachment level
prior to treatment and 12 weeks and 6 months after the treatment
BOP
Time Frame: prior to treatment and 12 weeks and 6 months after the treatment
bleeding on probing
prior to treatment and 12 weeks and 6 months after the treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tel Aviv University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Study Registration Dates

First Submitted

February 18, 2026

First Submitted That Met QC Criteria

February 25, 2026

First Posted (Actual)

March 3, 2026

Study Record Updates

Last Update Posted (Actual)

March 3, 2026

Last Update Submitted That Met QC Criteria

February 25, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 0011601-1

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

no personal data will be shared and/or disclosed. only periodontal parameters collected from the medical registries will be statistically analyzed and further published in the scientific literature

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

product manufactured in and exported from the U.S.

Yes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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