Intraoperative Pectoral Block vs IV Analgesia for Pain After Modified Radical Mastectomy

May 14, 2026 updated by: Islamabad Medical and Dental College

Comparison Between Intra-Operative Pectoral Block and Intravenous Analgesia for Post-Operative Pain Relief in Patients Undergoing Modified Radical Mastectomy

There is difference in post operative pain between patients receiving inter- pectoral block and those receiving standard Intravenous analgesia(INJ TORADOL) in patients undergoing Modified Radical Mastectomy.

To compare between these two methods , which one is better for post operative pain management.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
      • Islamabad, Pakistan, 44000
        • Akbar Niazi Teaching Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Female Patients undergoing Modified Radical Mastectomy for biopsy proven Carcinoma Breast
  • Patient with age 18-65 years
  • Patients with ASA Grade 2
  • BMI less than 40 kg/meter square

Exclusion Criteria:

  • Block site infection
  • Coagulopathies (INR > 1.6 and Platelets < 100000)
  • Any Organ dysfunction such as severe cardiac, pulmonary, renal or liver dysfunction
  • Systemic infection
  • Dementia
  • Known hypersensitivity to local anesthetic agents

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: PECs Arm
Drug: bupivacaine 0.5% injection
Intra-Operative Pectoral Block in Patients Undergoing Modified Radical Mastectomy for Post operative Pain management
Active Comparator: IV Analgesia Arm
Drug: Ketorolac 30 mg IV
Ketorolac 30mg administered Intravenously as a standard practice for post operative pain management in modified radical mastectomy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Postoperative Pain Severity at 24 hours Measured by Numeric Pain Rating Scale from 0-10 , where 0 is no pain and 10 is severe pain.
Time Frame: 24 hours Post Surgery
24 hours Post Surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Islamabad Medical and Dental College

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 1, 2025

Primary Completion (Actual)

December 15, 2025

Study Completion (Actual)

December 15, 2025

Study Registration Dates

First Submitted

November 19, 2025

First Submitted That Met QC Criteria

December 1, 2025

First Posted (Actual)

December 2, 2025

Study Record Updates

Last Update Posted (Actual)

May 15, 2026

Last Update Submitted That Met QC Criteria

May 14, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • No.179/IMDC/IREB-2025

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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