Expert Consensus on the Clinical Use of Skin Boosters: A Delphi-Based Recommendation Framework

December 8, 2025 updated by: Venus Research Center

This consensus research project aims to develop standardized, evidence-based recommendations for the clinical use of skin boosters in aesthetic dermatology. Despite their widespread adoption for improving skin hydration, texture, and dermal quality, current practice patterns vary significantly across clinicians and regions, with limited unified guidelines. Using a structured Delphi methodology, the study will gather expert opinions from dermatologists and aesthetic medicine specialists to achieve agreement on key aspects of skin booster therapy, including indications, patient selection, injection techniques, dosing protocols, product selection, treatment intervals, expected outcomes, and safety considerations.

The project seeks to establish practical, consensus-driven guidelines that can harmonize clinical practice, enhance treatment outcomes, and ensure patient safety. The final recommendations will serve as a reference framework for practitioners and contribute to the standardization of skin quality enhancement treatments.

Study Overview

Status

Enrolling by invitation

Conditions

Detailed Description

Skin boosters have become an increasingly popular modality in aesthetic dermatology due to their ability to enhance skin hydration, elasticity, texture, and overall dermal quality through minimally invasive intradermal injections. Despite their rapid integration into clinical practice, current approaches to skin booster therapy remain highly variable. Differences exist in product selection, injection depth, dosing regimens, treatment intervals, technique, indications, and safety monitoring. Moreover, the evidence base is still evolving, and most available data come from fragmented clinical studies or manufacturer-driven guidelines. As a result, there is a significant need for unified, expert-driven recommendations that can standardize practice, optimize patient outcomes, and minimize complications.

This research project aims to develop comprehensive, evidence-informed consensus guidelines for the use of skin boosters in aesthetic practice. The study will use a structured Delphi methodology to gather and synthesize the perspectives of leading dermatologists and aesthetic medicine specialists. Through multiple iterative rounds, experts will evaluate and rate a series of statements addressing key clinical domains including: appropriate indications; patient selection criteria; anatomical considerations; recommended injection depths and techniques; dosing strategies; frequency and number of treatment sessions; choice of products (e.g., HA-based, polynucleotides, bio-remodeling agents); combination therapies; expected outcomes; management of adverse events; and contraindications.

The consensus-building process ensures anonymity, reduces bias, and encourages equal participation among experts. Quantitative analyses (e.g., percentage agreement thresholds, median and interquartile range scoring) will be used to determine which statements achieve consensus. Statements not reaching agreement will be revised and re-evaluated in subsequent rounds until final consensus is achieved.

By the end of the project, the expert panel will produce clear, standardized, and clinically actionable recommendations that can be used globally or regionally to harmonize the use of skin boosters. These guidelines will support clinicians by improving the consistency and quality of care, informing training programs, guiding patient counseling, and reducing complication rates. Ultimately, the project aims to fill a critical gap in aesthetic dermatology literature by establishing a scientifically grounded, consensus-driven framework for safe and effective skin booster therapy

Study Type

Observational

Enrollment (Estimated)

15

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Cairo, Egypt
        • Venus Research Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

The study population will consist of a purposively selected panel of experts in aesthetic dermatology and skin booster therapy. Participants will include board-certified dermatologists, aesthetic physicians, and plastic surgeons with substantial clinical experience in administering injectable skin quality treatments. The expert panel will represent a diverse range of clinical backgrounds, geographical regions, and practice settings to ensure comprehensive and balanced perspectives.

Description

Inclusion Criteria:

  • Inclusion Criteria

Experts will be eligible to participate if they meet all of the following:

Board-certified dermatologist or aesthetic physician

With recognized qualification in dermatology, aesthetic medicine, plastic surgery, or related fields.

Minimum clinical experience

At least 5 years of experience performing aesthetic injectable procedures.

OR at least 3 years of consistent use of skin boosters in clinical practice.

Demonstrated expertise in skin booster therapy

Must have performed ≥100 skin booster procedures overall,

OR ≥20 sessions per year over the past 2 years.

Active clinical practice

Currently practicing in an aesthetic or dermatology clinic, medical center, or hospital.

Authorship or contribution to aesthetic/dermatology education (desirable but not mandatory)

Publications, lectures, workshop instruction, or conference involvement in aesthetics.

Ability to participate in Delphi rounds

Must agree to complete all survey rounds within the specified timeframe.

Must be fluent in the language used for the study (e.g., English or Arabic).

Willingness to provide informed consent

Voluntary participation with confidentiality maintained.

Exclusion Criteria:

  • Less than the required experience

<5 years of aesthetic practice

OR insufficient hands-on experience with skin booster injections.

Limited familiarity with skin booster products or techniques

No regular use in the last 2 years.

Has not performed the minimum number of required procedures.

Industry conflict of interest

Direct employment by a company manufacturing skin booster products.

Significant financial relationship with a single product manufacturer that may bias responses.

Inability to commit to multiple Delphi rounds

Anticipated non-compliance or non-response in iterative rounds.

Non-clinical or administrative professionals

Those not actively practicing (e.g., retired, research-only positions, students, trainees).

Participation in a competing guideline project

Experts currently serving on another skin booster consensus panel to avoid duplication or bias.

Failure to provide informed consent

Declines participation or withdraws consent at any time.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Expert Panel
A cohort of dermatology and aesthetic medicine experts participating in a Modified Delphi process to develop consensus recommendations on skin booster use.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Degree of Consensus on Clinical Recommendations
Time Frame: 6-12 weeks

  1. Degree of Consensus on Clinical Recommendations

    Definition: The level of expert agreement on each statement related to skin booster therapy.

    Measurement Method:

    Likert scale ratings (e.g., 1-9).

    Consensus threshold often defined as:

    ≥75% agreement within the 7-9 range (agreement)

    ≤15% ratings in the 1-3 range (disagreement)

    Outcome: Identification of statements that meet consensus criteria for inclusion in the final guideline.

  2. Development of Final Consensus Guidelines

Definition: The creation of a unified, evidence-informed set of recommendations on skin booster use.

Measurement Method:

Number of statements that reach consensus across all Delphi rounds.

Completeness of guideline domains (indications, technique, dosing, safety, etc.).

Outcome: A finalized recommendations document for clinicians.
6-12 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Implementation Readiness of Final Recommendations
Time Frame: 6-12 weeks

Definition: Practicality and ease of applying the guidelines in real-world clinical settings.

Measurement Method:

Expert evaluation of feasibility (Likert scale).

Assessment of clarity and actionability of statements.

Outcome: Determines how applicable the recommendations are in routine practice.
6-12 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Venus Research Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 25, 2025

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

January 1, 2027

Study Registration Dates

First Submitted

December 8, 2025

First Submitted That Met QC Criteria

December 8, 2025

First Posted (Actual)

December 22, 2025

Study Record Updates

Last Update Posted (Actual)

December 22, 2025

Last Update Submitted That Met QC Criteria

December 8, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • Skin Booster-VenusRC

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Delphi studies do not collect patient data, medical records, biological samples, or identifiable clinical information. Experts only give opinions, not "IPD." Their responses are anonymized, and sharing identifiable expert-level responses is not required and often discouraged

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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