Knee Joint Position Sense in Knee Osteoarthritis
Knee Joint Position Sense Under Different Testing Conditions in Individuals With and Without Knee Osteoarthritis
Study Overview
Status
Conditions
Detailed Description
Knee proprioception plays a critical role in joint stability, movement control, and the accurate perception and reproduction of joint position. In individuals with knee osteoarthritis (OA), alterations in joint structures, mechanoreceptor function, pain, and sensorimotor control may compromise joint position sense and increase errors during active joint position reproduction. However, proprioceptive performance is not solely determined by disease-related changes and may also be influenced by the conditions under which proprioception is assessed.
Both visual input and body position may influence proprioceptive performance. Visual information can provide additional sensory cues that support joint position estimation, whereas the absence of visual information may increase reliance on somatosensory and proprioceptive afferent input. Body position may also modify proprioceptive performance by altering gravitational demands, muscle activation patterns, joint loading, and sensory information arising from muscles and periarticular structures. Therefore, differences in joint position reproduction between testing conditions may reflect the combined influence of visual and positional factors rather than the isolated contribution of either factor.
Despite the clinical relevance of knee joint position sense, it remains unclear whether proprioceptive performance obtained under different visual and positional testing conditions is comparable and whether the response to these conditions differs between individuals with and without knee OA. Examining these condition-dependent differences may contribute to a better understanding of how proprioceptive assessment protocols influence measured joint position sense and may facilitate the interpretation and standardization of proprioceptive assessments.
Accordingly, the primary aim of this study was to compare absolute angular error during active knee joint position reproduction from 90° to 30° of knee flexion between individuals with and without knee OA under two different testing conditions: sitting with visual input and prone without visual input. A secondary aim was to investigate whether age and pain intensity were associated with proprioceptive error in individuals with knee OA.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Locations
-
-
-
Ankara, Turkey (Türkiye)
- Lokman Hekim University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Age between 40 and 80 years,
- A confirmed diagnosis of knee osteoarthritis,
- Absence of any health condition that could interfere with the measurement procedures.
Exclusion Criteria:
- Refusal to participate in the study,
- Presence of a diagnosed neurological disorder that could affect the measurements,
- Presence of cardiopulmonary instability that could influence the measurements,
- History of knee-related trauma within the past year,
- Receipt of physiotherapy or rehabilitation treatment within the past year,
- History of knee-related surgery,
- Inability to follow verbal instructions due to insufficient cognitive function.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
|---|
|
Knee Osteoarthritis Group
Participants diagnosed with knee osteoarthritis.
|
|
2-True Control Group
Participants without a diagnosis of knee osteoarthritis.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Proprioception Measurement
Time Frame: Each measurement was repeated three times, with a 1-minute rest interval between trials. A 2-minute rest period was provided between the two testing positions to allow participants to change position and rest.
|
During the measurement, the inclinometer was positioned over the proximal one-third of the fibula, with its axis aligned with the knee joint line, and secured using a strap.
Measurements were performed in both the prone and sitting positions.
Participants were instructed to actively move their knee from 90° of flexion toward the target position of 30° of flexion.
Upon reaching the perceived target position, participants maintained the position for 5 seconds before returning to the starting position.
|
Each measurement was repeated three times, with a 1-minute rest interval between trials. A 2-minute rest period was provided between the two testing positions to allow participants to change position and rest.
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: ZAHİDE SEDA BAKTIR DOĞAN, Assist. Prof, Lokman Hekim University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- LHU-FTR-ZSBD-04
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.