Corneal Endothelial Cell Changes In Silicon Filled Eye (Endothelium)

June 26, 2026 updated by: Amr Abdelhamid, Minia University
The aim of this study is to evaluate corneal endothelial cell changes after pars plana vitrectomy in Rhegmatogenous Retinal detachment , compare the results using different silicon oil viscositites , and assess whether these changes are reversible after silicone removal or not .

Study Overview

Status

Active, not recruiting

Conditions

Detailed Description

The aim of this study is to evaluate corneal endothelial cell changes after pars plana vitrectomy in Rhegmatogenous Retinal detachment , compare the results using different silicon oil viscositites , and assess whether these changes are reversible after silicone removal or not .

Study Type

Observational

Enrollment (Actual)

40

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Minya, Egypt, 61111
        • Minia University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

All patients with Rhegmatodenous retinal detachment which need PPV will be included in this study.

Description

Inclusion Criteria:

- All patients with Rhegmatodenous retinal detachment which need PPV will be included in this study.

Exclusion Criteria:

  • Patients with corneal dystrophies or degeneration.
  • Patients with a history of refractive surgery, either corneal or phakic lOL implantation.
  • Patients with a history of keratoplasty.
  • Patients with history of retinal detachment surgery in the same eye.
  • Recurrent cases during the follow-up period will be removed from the study. 6. patients with gas tamponade 7. patients with silicon oil 1000 cs 8. patients with Retinal pathologies such as macular hole , diabetic changes 9. patients undergo phacovitrectomy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Corneal Endothelial Cell Changes In Silicon 5000 cs Filled Eye .
study of Corneal Endothelial Cell Changes In Silicon 5000 cs Filled Eye .
Corneal Endothelial Cell Changes In Silicon 2000 cTs Filled Eye .
study of Corneal Endothelial Cell Changes In Silicon 2000 cTs Filled Eye .

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Corneal Endothelial Cell Changes In Silicon Filled Eye .
Time Frame: 4 months
Corneal Endothelial Cell Changes cell density ( cells/ mm) , coeffient variation(%) In Silicon Filled Eye at 1 and 3 months postoperative
4 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Minia University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 15, 2025

Primary Completion (Estimated)

August 15, 2026

Study Completion (Estimated)

September 20, 2026

Study Registration Dates

First Submitted

January 9, 2026

First Submitted That Met QC Criteria

February 14, 2026

First Posted (Actual)

February 18, 2026

Study Record Updates

Last Update Posted (Actual)

June 30, 2026

Last Update Submitted That Met QC Criteria

June 26, 2026

Last Verified

June 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 1564/6/2025.

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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