Effects of E-Cigarette Use Among Young Egyptian Adults

Respiratory, Functional, and Radiological Effects of E-Cigarette Use Among Young 1 Egyptian Adults: A Cross-Sectional Study

Electronic cigarettes (E-cigarettes) have gained significant popularity as an alternative to traditional combustible tobacco cigarette smoking. E-cigarettes are marketed as a safer alternative to conventional smoking forms. Many chronic smokers suppose that e-cigarettes are risk-free and can be used effectively as a smoking cessation tool. The market size of e-cigarette is increasing because of its rising popularity among the youth even though it is not an approved Food and Drug Administration (FDA) product yet

Study Overview

• Status: Completed
• Conditions: E Cigarette Use
• Intervention / Treatment: Diagnostic test: Pulmonary Function test

Detailed Description

Most daily life activities as walking and household chores that affect quality of life are performed at a submaximal level of exertion. E-cigarettes may affect overall physical fitness and cardiovascular health. It is important to evaluate responses of all body systems interacting during exercise, including cardiovascular and pulmonary function, systemic circulation, peripheral circulation, blood, neuromuscular units, muscle metabolism, oxygen transport and utilization within skeletal muscles. The knowledge gap regarding the potential negative health effects of E-cigarettes is crucial, as e-cigarettes are newly prevailing smoking tools that are gaining rising popularity among the youth. Additionally, the false perception of the unregulated electronic cigarette smoking as a safe recreational habit may increase the prevalence among the population. The aim of this work is to assess the clinical and functional impact of E-cigarettes garette use in young Egyptian adults, and to evaluate the role of chest CT in follow-up of identified abnormalities.

• Study Type: Observational
• Enrollment (Actual): 104

Contacts and Locations

Study Locations

• Egypt
  • Al Mansurah, Egypt, 35516
    • Mohamed AbdElmoniem

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

A total of 104 participants were enrolled and allocated into two equal groups: Group I: Exclusive e-cigarette users (n = 52) and Group II: Non-smoker controls (n = 52).

Description

Inclusion Criteria:

• Age > 18 years
• E-cigarette users (≥6 months of regular use)
• No prior history of chronic pulmonary disease

Exclusion Criteria:

• Dual users (both e-cigarettes and traditional tobacco)
• History of chronic respiratory illnesses (e.g., asthma, COPD)
• immunocompromised
• Systemic chronic diseases

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Non-smoker controls; Patients were included with Age ≥ 18 years, Non smokers	Diagnostic test: Pulmonary Function test; Spirometry was performed measure forced expiratiory volume at 1st second (FEV₁), forced vital capacity (FVC), and FEV₁/FVC ratio.
Exclusive e-cigarette users; Patients were included if Age ≥ 18 years, Exclusive e-cigarette users (Participants were considered exclusive e-cigarette users if they had used e-cigarettes regularly for ≥ 6 months).	Diagnostic test: Pulmonary Function test; Spirometry was performed measure forced expiratiory volume at 1st second (FEV₁), forced vital capacity (FVC), and FEV₁/FVC ratio.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Spirometer parameters assessment	Spirometry was performed to measure forced expiratory volume at 1st second (FEV₁)	3 months
Spirometer assessment	Spirometry was performed to measure FEV₁/FVC ratio	3 months
Spirometer	Spirometry was performed to measure forced vital capacity (FVC)	3 months

Collaborators and Investigators

• Sponsor: Mansoura University Hospital
• Investigators: Principal Investigator: Mohamed AbdElmoniem, Lecturer of chest medicine faculty of medicine Mansoura university

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2025
• Primary Completion (Actual): December 31, 2025
• Study Completion (Actual): February 1, 2026

Study Registration Dates

• First Submitted: February 12, 2026
• First Submitted That Met QC Criteria: February 18, 2026
• First Posted (Actual): February 20, 2026

Study Record Updates

• Last Update Posted (Actual): February 20, 2026
• Last Update Submitted That Met QC Criteria: February 18, 2026
• Last Verified: February 1, 2026

More Information

Terms related to this study

• Keywords: Vaping; E-cigarettes
• Additional Relevant MeSH Terms: Behavior; Smoking; Vaping; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Respiratory System; Respiratory Function Tests
• Other Study ID Numbers: R.25.09.3347

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No