Retrospective Analysis of Acute Pancreatitis After Percutaneous Mechanical Thrombectomy In Treatment Of Thrombotic Disorders

Retrospective Analysis of Acute Pancreatitis After Percutaneous Mechanical Thrombectomy In Treatment Of Thrombotic Disorders (The RATIO Study)

Acute pancreatitis is a rare complication after percutaneous mechanical thrombectomy in treatment of thrombotic disorders. The objectives of this study include: (1) Determine the incidence and severity of acute pancreatitis after percutaneous mechanical thrombectomy; (2) Identify patient/procedural risk factors; (3) Evaluate clinical outcomes; (4) Develop a diagnosis and treatment pathway.

Study Overview

• Status: Recruiting
• Conditions: Thrombotic Disorders; Acute Pancreatitis (AP)

Detailed Description

Percutaneous mechanical thrombectomy (PMT) has seen increasing utilization in the management of acute thrombotic events within both arterial and venous systems. The rheolytic thrombectomy such as AngioJet system employs hydrodynamic principles to disrupt and remove thrombus. The efficacy and safety have been demonstrated across various vascular diseases, including deep venous thrombosis (DVT), peripheral arterial occlusions, and dialysis access thrombosis, establishing PMT as a valuable minimally invasive therapeutic option. Acute pancreatitis is a serious inflammatory condition commonly associated with gallstones, alcohol consumption, hyperlipidemia, or metabolic disorders. Only isolated case reports have documented this complication following PMT. Despite the well-documented occurrence of other procedure-related adverse events, such as bradycardia, hemoglobinuria, and renal impairment, pancreatitis remains an exceptionally rare and under-recognized complication. The objectives of this study include: (1) Determine the incidence and severity of acute pancreatitis after percutaneous mechanical thrombectomy; (2) Identify patient/procedural risk factors; (3) Evaluate clinical outcomes; (4) Develop a diagnosis and treatment pathway.

• Study Type: Observational
• Enrollment (Estimated): 10

Contacts and Locations

• Study Contact: Name: Qihong Ni; Phone Number: 15801900772; Email: niqihong1989@163.com

Study Locations

• China
  • Shanghai Municipality
    • Shanghai, Shanghai Municipality, China, 200217
      • Recruiting
      • Renji Hospital
      • Contact: Qihong Ni; Phone Number: 15801900772; Email: niqihong1989@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Patients with acute pancreatitis after percutaneous mechanical thrombectomy for thrombotic disorders

Description

Inclusion Criteria:

• Patients over 18 years old;
• Patients with thrombotic peripheral vascular diseases treated by percutaneous mechanical thrombectomy;
• Patients developed acute pancreatitis within 14 days after percutaneous mechanical thrombectomy;
• Patients with written informed consent.

Exclusion Criteria:

• Patients with acute pancreatitis attributed to other confirmed causes;
• Patients unable or unwilling to participate in the study.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Acute pancreatitis after percutaneous mechanical thrombectomy group; Patients were diagnosed with acute pancreatitis after percutaneous mechanical thrombectomy in treatment of thrombotic disorders.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of acute pancreatitis	The incidence of acute pancreatitis within 14 days after mechanical thrombectomy for peripheral thromboembolic disease.	Within 14 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of acute severe pancreatitis	The incidence of acute severe pancreatitis within 14 days after mechanical thrombectomy for peripheral thromboembolic disease.	Within 14 days

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Admission to intensive care unit rate	Safety outcomes: Admission to intensive care unit rate within 60 days after mechanical thrombectomy for peripheral thromboembolic disease	Within 60 days
All-cause mortality rate	Safety outcomes: All-cause mortality rate within 60 days after mechanical thrombectomy for peripheral thromboembolic disease during hospitalization	within 60 days

Collaborators and Investigators

• Sponsor: RenJi Hospital
• Investigators: Principal Investigator: Qihong Ni, Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2016
• Primary Completion (Estimated): March 31, 2026
• Study Completion (Estimated): December 31, 2026

Study Registration Dates

• First Submitted: February 27, 2026
• First Submitted That Met QC Criteria: March 3, 2026
• First Posted (Actual): March 5, 2026

Study Record Updates

• Last Update Posted (Actual): March 5, 2026
• Last Update Submitted That Met QC Criteria: March 3, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: Thrombectomy
• Additional Relevant MeSH Terms: Digestive System Diseases; Pancreatic Diseases; Pancreatitis
• Other Study ID Numbers: The RATIO Study

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No