Patient Satisfaction and Postoperative Outcomes Following All-on-Four Implant Surgery Under Analgosedation

Patient Satisfaction and Postoperative Outcomes Following All-on-Four Implant Surgery Under Analgosedation: A Prospective Study

Objective: To evaluate patient satisfaction, postoperative pain, inflammatory re-sponse, and analgesic consumption following All-on-Four implant surgery performed under analgosedation.

Methods: This prospective clinical study will include 30 adult patients classified as ASA physical status I-II who were scheduled for elective full-arch rehabilitation using the All-on-Four protocol under analgosedation. Patients with contraindications to sedation, cognitive impairment, or emergency indications will be excluded. Postoperative pain and swelling will be assessed using a visual analogue scale (VAS) up to 72 hours. Real analgesic consumption will be recorded during the first three postoperative days. Systemic inflammatory response will be evaluated by serum C-reactive protein (CRP) levels measured preoperatively and on postoperative day 3. Patient experience with anesthetic management will be assessed using a structured questionnaire.

Study Overview

• Status: Completed
• Conditions: Parodontopathy
• Intervention / Treatment: Procedure: Full arch rehabilitation with four dental implants

• Study Type: Observational
• Enrollment (Actual): 30

Contacts and Locations

Study Locations

• Croatia
  • Zagreb, Croatia
    • Dental Center, St.Caherine Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

This prospective clinical study will include 30 patients classified as ASA physical status I-II who need to underwent full-arch rehabilitation using the All-on-Four implant concept

Description

Inclusion Criteria:

• Adult patients scheduled for elective full-arch implant rehabilitation
• ASA physical status I or II
• Ability to understand the study procedures and provide written informed consent

Exclusion Criteria:

• Emergency dental or surgical intervention
• Pregnancy
• Patients with cognitive impairment or psychiatric conditions affecting reliable outcome reporting
• Patients with contraindications to analgo-sedation

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Analgosedation; Adult patients classified as ASA physical status I-II who were scheduled for elective full-arch rehabilitation using the All-on-Four protocol under analgosedation	Procedure: Full arch rehabilitation with four dental implants; The elective full-arch rehabilitation using the All-on-Four protocol under analgosedation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Patient Reported postoperative pain andswelling	The primary outcome measures included patient-reported postoperative pain and swelling, analgesic use and systemic inflammatory response. Postoperative pain intensity and swelling were assessed using a 10-point Visual Analogue Scale (VAS), where 0 indicated the absence of symptoms and 10 indicated the maximum perceived severity. Assessments were performed preoperatively and at 2, 6, 12, 24, 48, and 72 hours postoperatively.	"From enrollment to the end of treatment at 3 days"
Rescue analgesic consumption	Rescue analgesic consumption was recorded for each patient during the first three postoperative days and quantified based on the total number of tablets consumed and daily dose. Analgesic intake was used as an indirect indicator of postoperative discomfort.	From surgery up to 3rd postoperative day
The systemic inflammatory response	To evaluate the systemic inflammatory response, serum C-reactive protein (CRP) levels were measured preoperatively and on postoperative day 3 using standard laboratory procedures.	"From enrollment to the end of treatment at 3 days"

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Patient experience with analgosedation	All patients were asked to complete a structured questionnaire assessing their experience with anesthetic management. The questionnaire collected demographic data and medical history, and included items related to previous exposure to analgosedation, attitudes toward different anesthesia modalities, perioperative anxiety, adequacy of preoperative information, patient involvement in anesthesia decision-making, and overall satisfaction with the anesthetic care. In addition, patients were asked to report intraoperative and early postoperative discomfort, adverse sensations following emergence from analgosedation, and their willingness to undergo the same anesthesia protocol in the future	"From enrollment to the end of treatment at 3 days"

Collaborators and Investigators

• Sponsor: University of Zagreb
• Collaborators: St. Catherine Specialty Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2026
• Primary Completion (Actual): March 31, 2026
• Study Completion (Actual): April 1, 2026

Study Registration Dates

• First Submitted: February 11, 2026
• First Submitted That Met QC Criteria: March 6, 2026
• First Posted (Actual): March 10, 2026

Study Record Updates

• Last Update Posted (Actual): April 13, 2026
• Last Update Submitted That Met QC Criteria: April 7, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: 123456 (Innovate UK)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: All data if needed.
• IPD Sharing Time Frame: 1.1.2027 till 31.12.2027
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; ICF; CSR

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No