Behavioural Intervention to Decrease Exposure to Emerging Chemical Pollutants (INPOL)

March 12, 2026 updated by: Juan Pedro Arrebola Moreno, Universidad de Granada

Effectiveness of a Behavioural Intervention to Decrease Exposure to Emerging Chemical Pollutants Compared to Standard Lifestyle Recommendations Among Adults in Spain (INPOL): a 3-month Multicentre, Parallel-group, Superiority Randomized Controlled Trial

The purpose of this study is to evaluate the effectiveness of a behavioural intervention designed to reduce exposure to environmental chemical pollutants among adults in Spain.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

740

Phase

  • Phase 2
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Spain
    • Granada
      • Granada, Granada, Spain, 18007
        • Hospital Universitario Clínico San Cecilio
        • Contact:
      • Motril, Granada, Spain, 18600
        • Hospital Comarcal Santa Ana
        • Contact:
    • Madrid
      • Fuenlabrada, Madrid, Spain, 28942
        • Hospital Universitario de Fuenlabrada
        • Contact:
      • Madrid, Madrid, Spain, 28041
        • Hospital Universitario 12 de Octubre
        • Contact:
    • Melilla
      • Melilla, Melilla, Spain, 52001
        • Clínica de neurociencias Imbrain
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria for the Screening phase:

  • Not planning to change residence within one year after recruitment
  • Spanish fluency
  • Living independently in the community
  • WhatsApp user
  • Age 30-60 years
  • Providing signed informed consent

Exclusion Criteria for the Screening phase:

  • Unable to provide any of the required biological samples
  • Suffering any chronic condition that substantially hinders adherence to the trial protocol and/or affects pollutant analyses
  • Inability to understand the informed consent, questionnaires, or intervention
  • Already participating in another intervention trial at the time of recruitment
  • Pregnancy or lactation
  • Inability to communicate with the research team and/or to attend the follow-up visits

Inclusion Criteria for the Intervention Phase:

  • Not planning to change residence within one year after recruitment
  • Spanish fluency
  • Living independently in the community
  • WhatsApp user
  • Age 30-60 years
  • Providing signed informed consent
  • Participant of the Screening phase

Exclusion Criteria for the Intervention Phase:

  • Unable to provide any of the required biological samples
  • Suffering from any chronic condition that substantially hinders adherence to the trial protocol and/or affects pollutant analyses
  • Inability to understand the informed consent, questionnaires, or intervention
  • Already participating in another intervention trial at the time of recruitment
  • Pregnancy or lactation
  • Inability to communicate with the research team and/or attend follow-up visits

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Current recommendations
Participants will receive healthy lifestyle guidelines from the public healthcare system, supported by short talks
Behavioral: Guidelines from the public healthcare system
Healthy lifestyle guidelines from the public healthcare system, supported by short talks
Experimental: INPOL recommendations
Participants will receive informative guidelines focused on how to decrease environmental chemical pollutant exposure, supported by short talks and social network interaction
Behavioral: INPOL healthy lifestyle informative guidelines
Informative guidelines focused on how to decrease environmental chemical pollutant exposure, supported by short talks and social network interaction.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Difference between groups in the average number of measured pollutants that decrease by at least 5% from baseline to the 3 month follow up
Time Frame: From baseline to 3 month follow-up
From baseline to 3 month follow-up

Secondary Outcome Measures

Outcome Measure
Time Frame
Difference between groups in the average number of measured chemicals that increase by at least 5% from baseline to 3 month follow-up between groups
Time Frame: Baseline to 3 month follow-up
Baseline to 3 month follow-up
Difference between groups in the average individual chemical concentrations at 3-month follow-up
Time Frame: Baseline to 3 month follow-up
Baseline to 3 month follow-up

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Universidad de Granada

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

May 1, 2026

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

February 1, 2027

Study Registration Dates

First Submitted

March 6, 2026

First Submitted That Met QC Criteria

March 6, 2026

First Posted (Actual)

March 11, 2026

Study Record Updates

Last Update Posted (Actual)

March 16, 2026

Last Update Submitted That Met QC Criteria

March 12, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • PI23/01799

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Sharing Access Criteria

Under request

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • ICF
  • ANALYTIC_CODE

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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