Prevalence and Molecular Identification of Human Schistosomiasis

March 16, 2026 updated by: Intesar Heshmat Yousef, Assiut University

Prevalence and Molecular Identification of Human Schistosomiasis With Assessment of Associated Epidemiological Risk Factors in Assiut Governorate, Egypt

Schistosomiasis remains one of the most important parasitic diseases of public health concern, particularly in developing countries including Egypt. It is caused by a trematode worm (blood flukes) of the genus Schistosoma

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Schistosomiasis has been diagnosed in Egypt since pharaonic times (3200 B.C.) by recovering Schistosome eggs and antigens in ancient mummies.In Egypt, Schistosoma mansoni and Schistosoma haematobium have historically been highly endemic, with widespread distribution along the Nile Delta and Valley.(4) Schistosoma haematobium is responsible for urogenital schistosomiasis, with hematuria as its primary manifestation, while Schistosoma mansoni, the prevalent species in Egypt, is causing intestinal schistosomiasis with liver-related sequelae

Study Type

Observational

Enrollment (Estimated)

359

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Probability Sample

Study Population

All participants presented in Assiut Governorate hospitals

Description

Inclusion Criteria:

  • Patients aged ≥ 5 years of both sexes attending Assiut Governorate hospitals during the study period.
  • Patients clinically suspected of having schistosomiasis (urinary and/or intestinal) or referred for parasitological examination.
  • Individuals (or guardians, in case of minors) who provide written informed consent.
  • Patients willing to provide the required biological samples (urine and/or stool).

Exclusion Criteria:

  • Patients Received praziquantel within the last 3 months before sample collection
  • Patients with incomplete clinical or epidemiological data.
  • Patients refusing participation or sample collection.
  • Improperly collected, contaminated, or insufficient samples.
  • Patients suffering from severe comorbid conditions that may interfere with the interpretation of results (e.g., advanced hepatic or renal failure).
  • children with congenital urinary or intestinal anomalies.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Schistosoma haematobium
Urine filtration technique (10 ml urine) for diagnosis
Diagnostic test: Molecular phylogenetic and haplotype analysis
DNA Sequencing and cox1 Gene Analysis of Schistosoma Isolates
Schistosoma mansoni
Direct wet mount and Kato-Katz thick smear technique (stool) for diagnosis
Diagnostic test: Molecular phylogenetic and haplotype analysis
DNA Sequencing and cox1 Gene Analysis of Schistosoma Isolates

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
prevalence of human schistosomiasis in the study participants
Time Frame: 24 hours
using conventional microscopic examination
24 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

May 1, 2026

Primary Completion (Estimated)

August 1, 2027

Study Completion (Estimated)

December 1, 2027

Study Registration Dates

First Submitted

March 16, 2026

First Submitted That Met QC Criteria

March 16, 2026

First Posted (Actual)

March 19, 2026

Study Record Updates

Last Update Posted (Actual)

March 19, 2026

Last Update Submitted That Met QC Criteria

March 16, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PMHS

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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