Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness

April 13, 2026 updated by: Ibrahim Mamdouh Esmat, Ain Shams University

Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness in Spontaneously Breathing Patients in Sepsis-related Acute Circulatory Failure: a Prospective Observational Study

Fluid responsiveness refers to the ability of the left ventricle to significantly increase stroke volume following fluid administration, and its assessment is critical in managing acute circulatory failure while avoiding fluid overload.Infraclavicular axillary vein collapsibility index is a substitute for inferior vena cava collapsibility index in assessment for the need of fluid resuscitation in spontaneously breathing sepsis related acute circulatory failure patients.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

40

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

  • Patients with sepsis must meet at least two or more criteria of systemic inflammatory response syndrome (SIRS).
  • Spontaneously breathing patients.
  • Clinical signs of acute circulatory failure.

Description

Inclusion Criteria:

  • Adult patients ≥18 years.
  • Patients with sepsis must meet at least two or more criteria of systemic inflammatory response syndrome (SIRS).
  • Spontaneously breathing patients.
  • Clinical signs of acute circulatory failure.

Exclusion Criteria:

  • Patients below the age of 18 years.
  • Mechanically ventilated patients

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The infraclavicular axillary vein collapsibility index changes in response to fluid challenge.
Time Frame: Fluid challenge over 10 min time period.
The infraclavicular axillary vein collapsibility index changes in response to fluid challenge. A collapsibility index greater than fifty percent in spontaneously breathing patients is commonly associated with a right atrial pressure between zero and five millimeters of mercury.
Fluid challenge over 10 min time period.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ain Shams University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 4, 2026

Primary Completion (Estimated)

November 4, 2026

Study Completion (Estimated)

November 4, 2026

Study Registration Dates

First Submitted

March 27, 2026

First Submitted That Met QC Criteria

March 27, 2026

First Posted (Actual)

April 2, 2026

Study Record Updates

Last Update Posted (Actual)

April 15, 2026

Last Update Submitted That Met QC Criteria

April 13, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • FMASU-MS 257 / 2026

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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