Neural Synchronization During Gesture Production and Comprehension in Individuals With Aphasia and Healthy Controls: A Study Using EEG Hyperscanning (RIAB_GESTO)

April 17, 2026 updated by: Sara Nordio, IRCCS San Camillo, Venezia, Italy
This study explores the neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, neural coupling between the encoder (PWA) and decoder (healthy participant) was analyzed during tasks involving social, affective, and informative gestures with both positive and negative emotional valence.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Gestures are essential in non-verbal communication, complementing speech by expressing emotions, intentions, and cognitive states. This study examines neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, we analyzed neural coupling between the encoder (PWA) and decoder (healthy participant) during tasks involving social, affective, and informative gestures with both positive and negative emotional valence. Methods: Seven dyads of participants participated in this study. The research was approved by the Ethical Committee of the IRCCS San CamilloHospital

Study Type

Observational

Enrollment (Actual)

7

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Italy
      • Venice-Lido, Italy
        • Sara Nordio

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Person with Aphasia due to left stroke

Description

Inclusion Criteria:

Age ≥ 18 years Diagnosis of left-sided stroke Clinical diagnosis of aphasia Native language: Italian (L1 Italian)

Exclusion Criteria:

History of psychiatric disorders

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Person with Aphasia
Behavioral: Person with Aphasia
EEG during gestures production

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
neural synchronization
Time Frame: during EEG hyperscanning recording

Neural synchronization between encoder and decoder

Description: Synchronization of activity in the alpha, beta, delta, and theta EEG bands between the encoder and decoder, assessed during task performance. Metrics will be reported separately for each frequency band.

Time Frame: At EEG recording
during EEG hyperscanning recording

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

IRCCS San Camillo, Venezia, Italy

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2022

Primary Completion (Actual)

August 1, 2023

Study Completion (Actual)

August 1, 2023

Study Registration Dates

First Submitted

March 25, 2026

First Submitted That Met QC Criteria

April 2, 2026

First Posted (Actual)

April 8, 2026

Study Record Updates

Last Update Posted (Actual)

April 22, 2026

Last Update Submitted That Met QC Criteria

April 17, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2021.23
  • Ethical Committee Veneto (Other Identifier: IRCCS San Camillo)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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