RECURRENT LARYNGEAL INJURY WHILE USING LIGASURE Versus CONVENTIONAL KNOT TYING IN TOTAL THYROIDECTOMY

April 4, 2026 updated by: Mudassar Malik, Gulab Devi Hospital

INCIDENCE OF RECURRENT LARYNGEAL INJURY WHILE USING LIGASURE IN TOTAL THYROIDECTOMY AS COMPARED TO CONVENTIONAL KNOT TYING

To compare the frequency of recurrent laryngeal injury during total thyroidectomy when utilizing the LigaSure technique against conventional knot tying.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

120

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
    • Punjab Province
      • Lahore, Punjab Province, Pakistan, 54600
        • Gulab Devi Hospital Ferozpur Road Lahore

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Aged: 18 to 60 years
  • Both Gender
  • Patients undergoing total thyroidectomy
  • Normal IDL
  • No Hoarseness of voice

Exclusion Criteria:

  • Patients requiring re-operation, including completion thyroidectomy.
  • Patients undergoing concurrent procedures such as cervical lymphadenectomy or parathyroidectomy.
  • Patient having previous neck surgery
  • Patient having neck radiation
  • Thyroidectomy for thyroid malignancy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Screening
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Group knot tying
Group A will consist of patients designated for total thyroidectomy with tie and knot hemostasis
Procedure: tie and knot
patients designated for total thyroidectomy with tie and knot hemostasis
Other Names:
  • Group conventional vessel sealing
Experimental: Group ligasure
Group B will comprise patients scheduled for total thyroidectomy using Ligasure for hemostasis
Procedure: Ligasure
Ligasure for hemostasis
Other Names:
  • Ligasure vessel sealing

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Recurrent laryngeal nerve injury
Time Frame: 3 days
Patients will be admitted to the hospital ward and assessed for recurrent laryngeal injury as per the operational definition during their stay.
3 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Gulab Devi Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 7, 2025

Primary Completion (Actual)

January 7, 2026

Study Completion (Actual)

March 25, 2026

Study Registration Dates

First Submitted

March 26, 2026

First Submitted That Met QC Criteria

April 4, 2026

First Posted (Actual)

April 13, 2026

Study Record Updates

Last Update Posted (Actual)

April 13, 2026

Last Update Submitted That Met QC Criteria

April 4, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AAMC/IRB/EA242025

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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