Evaluation of the PillCam™ Colon Capsule Endoscopy (PCCE) in the Visualization of the Colon
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
The Given® Diagnostic System offers an alternative approach for endoscopic visualization of the colon using capsule endoscopy, a swallowable device which contains imagers, light sources, a power source and a RF transmitter. Advantages of the Given® Diagnostic System include the elimination of the need for conscious sedation, the minimally invasive, painless nature of the exam, and the ability to pursue normal daily activities immediately following the procedure . This multi-center prospective, cohort study will evaluate the performance of PCCE in visualizing the colon. Up to 394 subjects will participate in this study. All subjects to be enrolled will be appropriate candidates for standard colonoscopy based on their clinical indication.
Each subject will undergo PCCE. All generated PCCE RAPID videos will be reviewed by blinded PCCE reading physicians. All readers, experienced in PillCam SB, will have undergone standardized training and passed a qualification test specific to reading and interpreting PCCE videos. Training will be done by reading at least 5 cases to demonstrate proficiency in interpretation of PCCE. PCCE results will be compared with that of a colonoscopy procedure.
Following PCCE procedure, standard colonoscopy will be performed by a colonoscopist blinded to the results of the PCCE. The colonoscopist will be "unblinded" during the standard colonoscopy procedure at three locations on withdrawal of the colonoscope.
Primary Endpoint - Accuracy parameters (sensitivity, specificity, NPV, PPV) of PCCE compared to standard colonoscopy.
• Number, type and severity of adverse events with both PCCE and standard colonoscopy
Undersøgelsestype
Tilmelding (Faktiske)
Kontakter og lokationer
Studiesteder
-
-
Arizona
-
Scottsdale, Arizona, Forenede Stater, 85259
- Mayo Clinic Arizona
-
-
Indiana
-
Indianapolis, Indiana, Forenede Stater, 46202
- Indiana University Hospital
-
-
Minnesota
-
Minneapolis, Minnesota, Forenede Stater, 55446
- Minnesota Gastroenterology
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic Rochester
-
-
New York
-
New York, New York, Forenede Stater, 10128
- Private Medical Facility
-
-
Oregon
-
Portland, Oregon, Forenede Stater, 97239-3098
- Oregon Health Sciences University
-
-
-
-
-
Haifa, Israel
- Rambam Medical Center
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion criteria:
Subjects must meet one the following inclusion criteria to be eligible for enrollment into this proposed study:
Subject was referred for standard colonoscopy for one of the following reasons:
Subjects over 50 years of age with one or more of the following clinical symptoms:
rectal bleeding, hematochezia, melena, positive FOBT, recent change of bowel habits
• Any subject over 18 years of age with:
- Positive findings in the colon on a GI radiographic study (e.g., CT colonography, air-contrast barium enema, abdominal/pelvic CT scan)
- Personal history of colorectal cancer (CRC) or adenomatous colonic polyps and at least 5 years since last colonoscopy or no sooner than 3 years prior to enrollment date as long as their prior colonoscopy revealed at least one of the following high risk conditions: multiple (greater than 3)adenomas, large adenoma (greater than 1 cm) , adenomas with a villous component, adenoma with high grade dysplasia.
- Suspected or known ulcerative colitis
Exclusion criteria
The presence of any of the following will exclude a subject from study enrollment:
- Subject has dysphagia
- Subject has congestive heart failure
- Subject has renal insufficiency
- Subject is known or is suspected to suffer from intestinal obstruction.
- Subject has a cardiac pacemaker or other implanted electro medical devices.
- Subject is pregnant
- Subject is expected to undergo MRI examination within 7 days after ingestion of the capsule.
- Subject has had prior abdominal surgery of the gastrointestinal tract other than uncomplicated procedures that would be unlikely to lead to bowel obstruction based on the clinical judgment of the investigator.
- Subject has any condition, which precludes compliance with study and/or device instructions.
- Age less than 18
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Tidsperspektiver: Fremadrettet
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Ledende efterforsker: Douglas Rex, M.D., Indiana University Hospital
- Ledende efterforsker: Glenn Eisen, M.D., Oregon Health and Science University
- Ledende efterforsker: Chris Gostout, MD, Mayo Clinic
- Ledende efterforsker: Blair Lewis, MD, Private Medical Facility
- Ledende efterforsker: S Ketover, MD, Minnesota Gastroenterology
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- MA-54
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
produkt fremstillet i og eksporteret fra U.S.A.
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Tyktarmssygdomme
-
Zunyi Medical CollegeThe First Affiliated Hospital of Zhengzhou University; Guizhou Provincial... og andre samarbejdspartnereIkke rekrutterer endnuHirschsprung sygdom | Total Colonic Aganglionosis | Duhamel | SoaveKina
Kliniske forsøg med PillCam Colon capsule endoscopy
-
Catholic University of the Sacred HeartAfsluttet
-
Medtronic - MITGAfsluttetInflammatorisk tarmsygdom | TyndtarmssygdomForenede Stater
-
Hospices Civils de LyonAfsluttet
-
Groupe d'Etude Therapeutique des Affections Inflammatoires...Aktiv, ikke rekrutterendeCrohns sygdomSpanien, Frankrig
-
Medtronic - MITGAfsluttet
-
Medtronic - MITGAfsluttetTyktarmssygdommeSpanien, Frankrig, Italien, Tyskland, Det Forenede Kongerige
-
IHU StrasbourgAfsluttetKolorektal cancerFrankrig
-
Odense University HospitalAfsluttet
-
Medtronic - MITGAfsluttetTyktarmssygdomme | TarmsygdommeForenede Stater
-
Melbourne HealthMedtronicAfsluttet