Suprapubic Versus Transurethral Catheterization After Rectal Resection With Low Anastomosis for Cancer in Males (GRECCAR10)
18. juli 2022 opdateret af: University Hospital, Grenoble
The purpose of this study is to compare the urinary tract infection rate on the four postoperative day between the 2 groups of patients who have undergone total mesorectal excision for cancer and low anastomosis, with either suprapubic or transurethral catheterization.
Studieoversigt
Status
Afsluttet
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
240
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Rhone Alpes
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Grenoble,, Rhone Alpes, Frankrig, 38000
- University Hospital Grenoble
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Han
Beskrivelse
Inclusion Criteria:
- Male patients of at least 18 years of age
- Histologically proven rectal adenocarcinoma
- Stage T1-4 Nx Mx
- With or without neoadjuvant treatment
- TME and low anastomosis (colorectal or coloanal, stapled or handsewn)
- With or without loop ileostomy
- Open or laparoscopic approach
- Patient and doctor have signed a study specific informed consent form
Exclusion Criteria:
- Colonic and upper third rectal cancer (No or Partial Mesorectal Excision)
- Abdominoperineal resection
- Associated prostate, and/or seminal glands and/or bladder resection
- Infected tumour, Emergency surgery
- Epidural analgesia
- Patient with antibiotic therapy (other than prophylaxis)
- Previous treated/untreated known prostate or bladder carcinoma
- Patient with symptomatic preoperative voiding dysfunction (IPSS score >19)
- Medical history of bladder catheterization for obstruction, or urethral surgery
- Patient necessitating urinary output monitoring (impaired renal function etc)
- Patient deprived of liberty or under guardianship or incapable of giving consent
- Against the usual indications of suprapubic drainage and / or urethral sounding any known allergies to medical device materials. (p. ex. latex) and in general the known allergies to sterilizing agents (particularly oxide ethylene and its derivatives.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Andet
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
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Eksperimentel: suprapubic catheterization
Intervention:suprapubic catheterization after rectal resection with low anastomosis.
Evaluate the urinary tract infection rate on the four days postoperative.
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Experimental Arm: Suprapubic catheterization after rectal resection with low anastomosis for cancer in males
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Aktiv komparator: transurethral catheterization
Intervention:transurethral catheterization after rectal resection with low anastomosis.
Evaluate the urinary tract infection rate on the four days postoperative.
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Active comparator: Transurethral catheterization after rectal resection with low anastomosis for cancer in males
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Number of participants with urinary tract infection when using suprapubic versus transurethral catheterization as assessed by significant bacteriuria and pyuria
Tidsramme: four days postoperative
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The urinary tract infection, defined as significant bacteriuria ( > 104 CFU / mL) and pyuria (> 6 white blood cells per high power field) in urine samples obtained immediately after removal of the urethral catheter or clamping suprapubic catheter and removing the fourth postoperative day.
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four days postoperative
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Duration of catherism as assessed by the number of days for participants with the catheter and number of participants leaving the hospital with the catheter
Tidsramme: 1 month
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1 month
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Pain as assessed by visual analogue scale (0 to 10 score) for abdomen and urethra
Tidsramme: at 1, 2, 3 and 4 days
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visual analogue scale (0-10) for both the abdomen and the urethra (a measure daily until hospital discharge )
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at 1, 2, 3 and 4 days
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Participants morbidity and mortality as assessed by Dindo and Clavien classification
Tidsramme: at 1 month and 6 months
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at 1 month and 6 months
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Rate of satisfaction for participants as assessed by questionnaries (Fact-C and EQ-5D-3L
Tidsramme: at 30 days and 6 months
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Patient satisfaction : very, or moderately dissatisfied , unchanged , slightly , moderately , or very disappointed at the exit of the Fact- C hospital and EQ-5D - 3L at 30 days and 6 months.
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at 30 days and 6 months
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Cost as assessed by the addition of the costs of the full process depending on the catheterism duration and additional consultations and readmissions for complications
Tidsramme: at 6 months
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Estimated cost of complications, urologic surgery, medication , hospitalization, additional consultations and readmissions.
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at 6 months
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Duration of hospital stay in days
Tidsramme: within 6 months
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the hospital stay by day
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within 6 months
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Rate of recatheterization
Tidsramme: in the first 6 months
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in the first 6 months
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Duration of postoperative return to normal bladder function as assessed by IPSS score
Tidsramme: at 1 and 6 months
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at 1 and 6 months
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Number of additionnal consultations
Tidsramme: in the first 6 months
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in the first 6 months
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Lack of comfort as assessed by visual analogue scale (0 to 10 score) for abdomen and urethra
Tidsramme: at 1, 2, 3 and 4 days
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visual analogue scale (0-10) for both the abdomen and the urethra (a measure daily until hospital discharge )
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at 1, 2, 3 and 4 days
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Specific complications
Tidsramme: in the first 6 months
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in the first 6 months
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Pr Jean Luc FAUCHERON, University Clinic of Digestive Surgery and Emergency
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Sethia KK, Selkon JB, Berry AR, Turner CM, Kettlewell MG, Gough MH. Prospective randomized controlled trial of urethral versus suprapubic catheterization. Br J Surg. 1987 Jul;74(7):624-5. doi: 10.1002/bjs.1800740731.
- Ratnaval CD, Renwick P, Farouk R, Monson JR, Lee PW. Suprapubic versus transurethral catheterisation of males undergoing pelvic colorectal surgery. Int J Colorectal Dis. 1996;11(4):177-9. doi: 10.1007/s003840050038.
- Perrin LC, Penfold C, McLeish A. A prospective randomized controlled trial comparing suprapubic with urethral catheterization in rectal surgery. Aust N Z J Surg. 1997 Aug;67(8):554-6. doi: 10.1111/j.1445-2197.1997.tb02037.x.
- Tambyah PA, Oon J. Catheter-associated urinary tract infection. Curr Opin Infect Dis. 2012 Aug;25(4):365-70. doi: 10.1097/QCO.0b013e32835565cc.
- Shah EF, Huddy SP. A prospective study of genito-urinary dysfunction after surgery for colorectal cancer. Colorectal Dis. 2001 Mar;3(2):122-5. doi: 10.1046/j.1463-1318.2001.00221.x.
- Sterk P, Shekarriz B, Gunter S, Nolde J, Keller R, Bruch HP, Shekarriz H. Voiding and sexual dysfunction after deep rectal resection and total mesorectal excision: prospective study on 52 patients. Int J Colorectal Dis. 2005 Sep;20(5):423-7. doi: 10.1007/s00384-004-0711-4. Epub 2005 Apr 22.
- Branagan GW, Moran BJ. Published evidence favors the use of suprapubic catheters in pelvic colorectal surgery. Dis Colon Rectum. 2002 Aug;45(8):1104-8. doi: 10.1007/s10350-004-6368-9.
- Lee SY, Kang SB, Kim DW, Oh HK, Ihn MH. Risk factors and preventive measures for acute urinary retention after rectal cancer surgery. World J Surg. 2015 Jan;39(1):275-82. doi: 10.1007/s00268-014-2767-9.
- Platt R, Polk BF, Murdock B, Rosner B. Mortality associated with nosocomial urinary-tract infection. N Engl J Med. 1982 Sep 9;307(11):637-42. doi: 10.1056/NEJM198209093071101.
- Rasmussen OV, Korner B, Moller-Sorensen P, Kronborg O. Suprapubic versus urethral bladder drainage following surgery for rectal cancer. Acta Chir Scand. 1977;143(6):371-4. No abstract available.
- Shapiro J, Hoffmann J, Jersky J. A comparison of suprapubic and transurethral drainage for postoperative urinary retention in general surgical patients. Acta Chir Scand. 1982;148(4):323-7.
- Piergiovanni M, Tschantz P. [Urinary catheterization: transurethral or suprapubic approach?]. Helv Chir Acta. 1991 Jul;58(1-2):201-5. French.
- O'Kelly TJ, Mathew A, Ross S, Munro A. Optimum method for urinary drainage in major abdominal surgery: a prospective randomized trial of suprapubic versus urethral catheterization. Br J Surg. 1995 Oct;82(10):1367-8. doi: 10.1002/bjs.1800821024.
- Baan AH, Vermeulen H, van der Meulen J, Bossuyt P, Olszyna D, Gouma DJ. The effect of suprapubic catheterization versus transurethral catheterization after abdominal surgery on urinary tract infection: a randomized controlled trial. Dig Surg. 2003;20(4):290-5. doi: 10.1159/000071693. Epub 2003 Jun 5.
- McPhail MJ, Abu-Hilal M, Johnson CD. A meta-analysis comparing suprapubic and transurethral catheterization for bladder drainage after abdominal surgery. Br J Surg. 2006 Sep;93(9):1038-44. doi: 10.1002/bjs.5424.
- Niel-Weise BS, van den Broek PJ. Urinary catheter policies for short-term bladder drainage in adults. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004203. doi: 10.1002/14651858.CD004203.pub2.
- Healy EF, Walsh CA, Cotter AM, Walsh SR. Suprapubic compared with transurethral bladder catheterization for gynecologic surgery: a systematic review and meta-analysis. Obstet Gynecol. 2012 Sep;120(3):678-87. doi: 10.1097/AOG.0b013e3182657f0d.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
14. oktober 2016
Primær færdiggørelse (Faktiske)
18. maj 2020
Studieafslutning (Faktiske)
16. april 2021
Datoer for studieregistrering
Først indsendt
4. februar 2016
Først indsendt, der opfyldte QC-kriterier
3. oktober 2016
Først opslået (Skøn)
4. oktober 2016
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
21. juli 2022
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
18. juli 2022
Sidst verificeret
1. juli 2022
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- 38RC14.457
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med suprapubic catheterization
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National Heart, Lung, and Blood Institute (NHLBI)AfsluttetPulmonal hypertension | Medfødt hjertesygdom | Caridovaskulær sygdomForenede Stater
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University College, LondonUniversity College London Hospitals; St Peter's Andrology CentreAfsluttetKateterrelateret komplikation | TranskønnethedDet Forenede Kongerige