ReStOre@Home: Feasibility Study of a 12-week Multidisciplinary Telehealth Rehabilitation Programme for Survivors of Upper Gastrointestinal (UGI) Cancer (ReStOre@Home)
5. April 2022 aktualisiert von: Prof Juliette Hussey, University of Dublin, Trinity College
Feasibility study of a 12-week multidisciplinary telehealth rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer
Studienübersicht
Status
Abgeschlossen
Bedingungen
Intervention / Behandlung
Detaillierte Beschreibung
A single arm feasibility study will be conducted to examine the feasibility of delivering the 12-week ReStOre programme (aerobic and resistance physiotherapy led-exercise, 1:1 dietary counselling and group education sessions) via telehealth to a cohort of upper gastrointestinal cancer survivors.
Studientyp
Interventionell
Einschreibung (Tatsächlich)
12
Phase
- Unzutreffend
Kontakte und Standorte
Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.
Studienorte
-
-
Leinster
-
Dublin, Leinster, Irland
- Trinity College Dublin
-
-
Teilnahmekriterien
Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.
Zulassungskriterien
Studienberechtigtes Alter
18 Jahre bis 100 Jahre (Erwachsene, Älterer Erwachsener)
Akzeptiert gesunde Freiwillige
Nein
Studienberechtigte Geschlechter
Alle
Beschreibung
Inclusion Criteria:
- be ≥ three months post oesophagectomy, total gastrectomy
- ± neo-adjuvant/adjuvant chemo/chemoradiotherapy with curative intent
- adjuvant therapy must be completed
- access to home broadband
Exclusion Criteria:
- Ongoing serious post-operative morbidity
- Evidence of active or recurrent disease.
In addition those with any serious co-morbidity that would impact on exercise participation will be excluded including those with;
- Uncontrolled hypertension (resting systolic blood pressure >180mmHg and/or diastolic >100mmHg)
- Recent serious cardiovascular events (within 12 months) including, but not limited to cerebrovascular accident, and myocardial infarction
- Unstable cardiac, renal, lung, liver or other severe chronic disease
- Uncontrolled atrial fibrillation
- Left ventricular function <50%.
Studienplan
Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.
Wie ist die Studie aufgebaut?
Designdetails
- Hauptzweck: Behandlung
- Zuteilung: N / A
- Interventionsmodell: Einzelgruppenzuweisung
- Maskierung: Keine (Offenes Etikett)
Waffen und Interventionen
Teilnehmergruppe / Arm |
Intervention / Behandlung |
|---|---|
|
Experimental: Intervention Arm
Single arm trial, all participants will receive the intervention
|
12 week programme of; 1) Physiotherapy led aerobic and resistance exercise 2)1:1 Dietetics Counselling 3) Group Multidisciplinary Education Sessions |
Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
|
Feasibility - Recruitment
Zeitfenster: Through study completion approx 1 year
|
Feasibility will be determined by recruitment rate, the number of eligible participants who consent to participation.
|
Through study completion approx 1 year
|
|
Feasibility - adherence
Zeitfenster: From baseline (T0) to immediately after the program intervention (T1)
|
Feasibility will also be determined by adherence to the trial intervention, the number of prescribed intervention sessions completed.
|
From baseline (T0) to immediately after the program intervention (T1)
|
|
Feasibility - acceptability of the intervention (1)
Zeitfenster: Immediately after the program intervention (T1)
|
Feasibility will also be determined by the acceptability of the programme. Acceptability of the telehealth programme will be assessed by the Telehealth Usability Questionnaire (TUQ). The Telehealth Usability scale is a 5 point likert scale where 1 = completely disagree, and 5 =fully agree, Higher ratings indicate better usability. |
Immediately after the program intervention (T1)
|
|
Feasibility - acceptability of the intervention (2)
Zeitfenster: Duration of the trial i.e. From enrolment of the first participant until completion of the final participants post-intervention assessment (Time period of up to 12 months).
|
Acceptability of the intervention will be further determined by a qualitative approach.Interviews will be carried out with participants post-intervention to gain their perspectives of the impact of the program on physical and mental well-being and the suitability of the programme to delivery via telehealth
|
Duration of the trial i.e. From enrolment of the first participant until completion of the final participants post-intervention assessment (Time period of up to 12 months).
|
Sekundäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
|
Change in Cardiorespiratory Fitness from Baseline
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Cardiorespiratory fitness will be determined by Cardiopulmonary Exercise Test (CPET)
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Physical Performance
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Physical Performance will be measured with the Short Physical Performance Battery
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Hand Grip Strength
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Hand Grip strength will be measured with hand held dynamometry
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Physical Activity
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Physical activity will be measured using the Godin Shepherd Leisure-Time Exercise Questionnaire.
A score of 24 indicates the individual is active, 14-23 indicates moderately active, and less than 14 indicates sedentary/ insufficiently active.
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Weight
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Weight will be recorded by standard measures and reported in kilograms (kg).
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Height
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Height will be recorded by standard measures and reported in meters (m)
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Body Mass Index
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Body Mass Index (BMI) will be calculated as weight (kg)/height (meters(m2)) and reported in kilograms/metres squared (kg/m2).
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Circumferential Measurements
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Mid-arm circumference and waist circumference will be measured with a flexible tape measure and reported in centimeters (cm)
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Health Related Quality of Life measured by the European Organisation for the Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC-QLQ-C30)
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Quality of Life will be determined by the European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC-QLQ-C30). Scores are reported on a linear scale from 0-100. A high score in a functional scale indicates greater function. A high score in a symptom scale indicates greater symptom burden. |
Baseline (T0), Immediately after the program intervention (T1)
|
|
Oesophago-gastric cancer specific Health Related Quality of Life will measured by the European Organisation for the Research and Treatment of Cancer Oesophago-gastric Cancer Subscale the EORTC-QLQ-OG25.
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Oesophagogastric cancer specific quality of life will be determined by the EORTC-QLQ-OG25 subscale. Scores are reported on a linear scale from 0-100. A high score in a functional scale indicates greater function. A high score in a symptom scale indicates greater symptom burden. |
Baseline (T0), Immediately after the program intervention (T1)
|
|
Fatigue
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Fatigue will be assessed using the Multidimensional Fatigue Inventory (MFI-20) questionnaire.
It is scored from 0-20.
A cut off score of >or =13 indicates severe fatigue.
|
Baseline (T0), Immediately after the program intervention (T1)
|
|
Bio-sample Collection
Zeitfenster: Baseline (T0), Immediately after the program intervention (T1)
|
Serum, Plasma and Whole Blood samples will be collected at each time-point to establish a survivorship Biobank for UGI cancer.
These samples will be stored in the biobank for future to be determined studies.
|
Baseline (T0), Immediately after the program intervention (T1)
|
Mitarbeiter und Ermittler
Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.
Mitarbeiter
Publikationen und hilfreiche Links
Die Bereitstellung dieser Publikationen erfolgt freiwillig durch die für die Eingabe von Informationen über die Studie verantwortliche Person. Diese können sich auf alles beziehen, was mit dem Studium zu tun hat.
Studienaufzeichnungsdaten
Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.
Haupttermine studieren
Studienbeginn (Tatsächlich)
1. Mai 2021
Primärer Abschluss (Tatsächlich)
30. Oktober 2021
Studienabschluss (Tatsächlich)
1. Januar 2022
Studienanmeldedaten
Zuerst eingereicht
21. September 2020
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
23. Oktober 2020
Zuerst gepostet (Tatsächlich)
26. Oktober 2020
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
13. April 2022
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
5. April 2022
Zuletzt verifiziert
1. April 2022
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Andere Studien-ID-Nummern
- DIFA-2018-009 - ReStOre@Home
Plan für individuelle Teilnehmerdaten (IPD)
Planen Sie, individuelle Teilnehmerdaten (IPD) zu teilen?
Nein
Arzneimittel- und Geräteinformationen, Studienunterlagen
Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt
Nein
Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt
Nein
Produkt, das in den USA hergestellt und aus den USA exportiert wird
Nein
Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .
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