Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient

Resuscitation Failure, Protein Carbonyl and Receptor Interacting Protein Kinase 3 as Mortality Predictor in Septic Patient

Patrocinadores

Patrocinador principal: Universitas Sriwijaya

Colaborador: Indonesia University

Fuente Universitas Sriwijaya
Resumen breve

Resuscitation failure, oxidative stress and necroptosis were able to predict mortality in septic patient

Descripción detallada

This prospective cohort study was conducted at resuscitation room and ICU of Mohammad Hoesin hospital, a single tertiary teaching hospital in Palembang, South Sumatera. This study was started after ethical and location authorization were unleashed in February to August 2019. Inclusion criteria were patients aged 18 years old or above who met Sepsis-3 definition and diagnosed with sepsis. Exclusion criteria were patients whose family did not give any consent to participate, not treated at the ICU, had a late diagnosis (>24 h), pregnant, and diagnosed with brain dead. Drop out criteria including patients who died <4 h after diagnosed and could not be followed in 28 days. Investigators were trained to identified all eligible subjects. All the subjects had a standard resuscitation and their blood was taken to be examined at the laboratory. Subjects were observed in 28 days whether there were any mortality or not. Failed resuscitation defined by examined lactate level ≥ 2 mmol/L or lactate reduction <20%. Data was statistically analyzed with STATA™

Estado general Completed
Fecha de inicio February 22, 2019
Fecha de Terminación August 20, 2019
Fecha de finalización primaria August 20, 2019
Tipo de estudio Observational [Patient Registry]
Resultado primario
Medida Periodo de tiempo
The Ability of Resuscitation Failure, Protein Carbonyl (PCO) and Receptor Interacting Protein Kinase 3 (RIPK3) for Predicting Mortality in Septic Patients 28 days
Resultado secundario
Medida Periodo de tiempo
How Sensitive and Specific Protein Carbonyl (PCO) Level for Predicting Mortality in Septic Patients? 28 days
How Sensitive and Specific Receptor Interacting Protein Kinase 3 (RIPK3) Level for Predicting Mortality in Septic Patients? 28 days
Inscripción 72
Condición
Intervención

Tipo de intervención: Diagnostic Test

Nombre de intervención: Blood Collection

Descripción: Blood Gas Analysis using Stat Profile pHOx® Series (nova biomedical, Waltham, U.S.) and Enzym-linked Immunosorbent Assay (ELISA) using Bio-Rad (Bio-Rad Laboratories, California, U.S.)

Elegibilidad

Método de muestreo: Non-Probability Sample

Criterios:

Inclusion Criteria:

- Participants aged 18 years old or above

- Diagnosed sepsis using Sepsis-3 definition

Exclusion Criteria:

- Participants whose family did not give any consent to participate

- Not treated at the ICU

- Had a late diagnosis (>24 h)

- Pregnant

- Brain dead

Género: All

Edad mínima: 18 Years

Edad máxima: N/A

Ubicación
Instalaciones: Mohammad Hoesin Central General Hospital
Ubicacion Paises

Indonesia

Fecha de verificación

November 2019

Fiesta responsable

Tipo: Principal Investigator

Afiliación del investigador: Universitas Sriwijaya

Nombre completo del investigador: Mayang Indah Lestari

Título del investigador: Principal Investigator

Tiene acceso ampliado No
Grupo de brazo

Etiqueta: Resuscitation Failure, High PCO Level, High RIPK3 Level

Descripción: Resuscitation failure was defined as lactate level ≥2 mmol/L or lactate reduction <20% hour-4 after initial sepsis recognition. High PCO level was defined as PCO level ≥ cut off point. High RIPK3 level was defined as PCO level ≥ cut off point.

Etiqueta: Resuscitation Success, Low PCO Level, Low RIPK3 Level

Descripción: Resuscitation success was defined as lactate level <2 mmol/L or lactate reduction ≥20% hour-4 after initial sepsis recognition. Low PCO level was defined as PCO level < cut off point. Low RIPK3 level was defined as PCO level < cut off point.

Información de diseño del estudio

Modelo de observación: Cohort

Perspectiva de tiempo: Prospective

Fuente: ClinicalTrials.gov