El papel de los subconjuntos de células inmunitarias que responden a IL-23 en la recurrencia posoperatoria en pacientes con enfermedad de Crohn. (DIVE-23)
Un estudio exploratorio para examinar el papel de los subconjuntos de células inmunitarias que responden a IL-23 en la recurrencia posoperatoria en pacientes con enfermedad de Crohn.
Inflammatory Bowel Diseases (IBDs), including ulcerative colitis and Crohn's disease (CD), constitute a group of debilitating chronic diseases that profoundly impact patient quality of life and incurs large costs in terms of treatment and lost productivity. Incidence of IBD is rising worldwide, and there is a pressing clinical need for development of new therapies. Discovery and development of effective therapies to treat IBDs depend first on a better understanding of the underlying mechanisms, including how proinflammatory cells proliferate unchecked.
It has been established that the cytokine interleukin (IL)-23 plays a pivotal role in IBD pathophysiology and antibodies targeting IL-23 are currently in late stage development for the treatment of both CD and ulcerative colitis (UC). IL-23 is part of the IL-12 family of cytokines (which includes IL-12, IL-27 and IL-35). The p40 subunit is shared among IL-23 and IL-12; the p19 subunit is unique to IL-23. Thus far, the efficacy of selective anti-IL-23 blockade (via anti-p19 antibodies) appears 5-10% better with respect to clinical and endoscopic outcomes than targeting both IL-23 and IL-12 using anti-p40 antibodies. Understanding the effects of IL-23 (and IL-12) in IBDs requires identification of the most relevant immune cells that respond to these cytokines. One likely cell type controlled by the IL-23 pathway are innate lymphoid cells (ILCs). ILC3s (a subset of ILCs) are dominant in healthy intestinal tissue and capable of producing IL-22 which maintain intestinal epithelial homeostasis. Disturbances in the amounts of IL-22 caused by changes in the stimulatory cytokine IL-23 in tissues, may therefore cause inflammatory responses. IL-23 may facilitate the IL-12-induced shift of ILC3s to ILC1s which are contributing to the disease-causing chronic inflammation.
The DIVE 23 project is designed to understand the role of IL-23 in human IBD, in particular CD. It is hypothesized that IL-23R+ cells in the gut, are drivers of chronic inflammation in CD and determine the impact of IL-23 inhibition. To this end the investigators plan to extensively characterize the IL-23-responsive cell populations in inflamed and non-inflamed intestinal tissues of CD patients with postoperative recurrence in order to identify IL-23-responsive immune cell populations that are associated with disease activity. Patients will be treated in routine medical practice with biological agents and will undergo a second ileocolonoscopy 12-16 weeks later to investigate the impact of the different interventions on the mucosal immunology driving CD.
Descripción general del estudio
Estado
Condiciones
Tipo de estudio
Inscripción (Estimado)
Contactos y Ubicaciones
Estudio Contacto
- Nombre: Lotte Oldenburg
- Número de teléfono: 020 444 1125
- Correo electrónico: l.oldenburg@amsterdamumc.nl
Ubicaciones de estudio
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Ontario
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Toronto, Ontario, Canadá, 1X5
- Reclutamiento
- Mount Sinai
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Contacto:
- Joanne Stempak
- Correo electrónico: joanne.stempak@sinaihealth.ca
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Investigador principal:
- Mark Silverberg, dr
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North Holland
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Amsterdam, North Holland, Países Bajos, 1105
- Reclutamiento
- Amsterdam UMC
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Contacto:
- Lotte Oldenburg, drs
- Número de teléfono: +31 020 566 9111
- Correo electrónico: l.oldenburg@amsterdamumc.nl
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Sub-Investigador:
- Lotte Oldenburg, drs
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Investigador principal:
- Geert D'Haens, prof dr
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Método de muestreo
Población de estudio
The study will be performed in CD patients with postoperative recurrence. Patients will be counselled prior to their routine endoscopy (typically 6-9 months after surgery). In practice, this will be approximately be between one and two weeks before the routine endoscopy. The investigators intend to evaluate 20-30 patients for this study and recruit 40 patients. The reason for this, is that there is a possibility that patients do not have enough inflammation (Rutgeerts ≤i2a) and therefore cannot be included.
Descripción
Inclusion Criteria:
- Age >/= 18 years;
- Male or non-pregnant, non-lactating females;
- Patients with postoperative recurrence at routine endoscopy 6-24 months following resection, defined by presence of ulcerations (endoscopic Rutgeerts' score >i2a) in the neoterminal ileum;
- In the opinion of the investigator, the subject is capable of understanding and complying with protocol requirements;
- The subject signs and dates a written informed consent form and any required privacy authorization prior to the initiation of any study procedures.
Exclusion Criteria:
- Any conditions (eg, history of alcohol or substance abuse, or lack of compliance) which, in the opinion of the investigator, may interfere with the patient's ability to comply with study procedures;
- Any condition in which one of the potential treatments are contraindicated in the opinion of the investigator (eg, cardiac failure class 3-4 according to the New York Heart Association [NYHA], multiple sclerosis, active infections).
- Received any investigational drug in the past 30 days or 5 half-lives, whichever is longer.
- Currently participating or planning to participate in a study involving an investigational product.
- Active or planned pregnancy during the study.
- Prior diagnosis of dysplasia in the colon (excluding in resected adenomas).
- History of malignancy in the 3 years prior to randomization except for non-melanoma skin cancer.
- Received a biologic treatment between surgery and first endoscopy.
- Positive Clostridium difficile toxin B in faeces. Patients who test positive can be treated per local practice and still enter the study if no longer than 4 weeks after the screening visit, they test negative for Clostridium difficile toxin B.
- Presence of a stoma without ileocolonic anastomosis or pouch.
- Active perianal abscess or draining fistula
- ALT or AST > 3x the upper limit of normal measured at screening
- Increased risk of bleeding: coagulation disorder, use of anticoagulants and DOACs
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Modelos observacionales: COHORT
- Perspectivas temporales: PROSPECTIVE
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Changes in concentration and amounts of IL-23 responsive cells in postoperative CD at baseline endoscopy and after 12-16 weeks of routine care treatment with a biological agent.
Periodo de tiempo: Week 16
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Single cell analysis |
Week 16
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Changes in concentration and amounts in IL-23 pathway cytokines and mediators, at baseline and after 12-16 weeks of biological treatment.
Periodo de tiempo: Week 16
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Single cell analysis |
Week 16
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Change in modified Rutgeerts' score at baseline endoscopy and follow-up endoscopy (12-16 weeks after biological treatment)
Periodo de tiempo: Week 16
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Endoscopic outcome measurement |
Week 16
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Change in SES-CD score at baseline endoscopy and follow-up endoscopy (week 12-16, after biological treatment)
Periodo de tiempo: Week 16
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Endoscopic outcome measurement |
Week 16
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Change in the Harvey-Bradshaw Index (HBI) score at baseline visit and follow-up visits at week 8 and week 12-16.
Periodo de tiempo: Week 16
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Clinical outcome measurement |
Week 16
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Change in Robarts histopathology index (RHI) score at baseline endoscopy and follow-up endoscopy (week 12-16, after biological treatment).
Periodo de tiempo: Week 16
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Histology outcome measurement |
Week 16
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Colaboradores e Investigadores
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Estimado)
Finalización del estudio (Estimado)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- NL82888.018.22
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
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