Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves. (MechSens_Migra)
Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine - A Cross-Sectional Study
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden. In chronic migraine, central and peripheral sensitization mechanisms are considered key pathophysiological factors and may manifest, among other features, as altered mechanical pain sensitivity.
Quantitative assessment of mechanical pain sensitivity using pressure algometry is an established method; however, it is partly dependent on examiner technique and measurement protocols. The Algopeg® represents a standardized instrument for assessing mechanical pain sensitivity and may serve as a practical complement or alternative to classical pressure algometry. To date, evidence regarding the use of the Algopeg® in migraine populations remains limited.
In addition to increased mechanosensitivity in trigeminal and extra-trigeminal regions, peripheral nerve structures, such as branches of the greater occipital nerve and the supraorbital nerve, may show sensitivity to mechanical stimuli during neurodynamic testing or palpation. This may have clinical relevance, as these regions are often targeted in symptomatic and prophylactic treatments.
The aim of this study is to systematically investigate mechanical pain sensitivity, headache-related outcomes, and quality of life in patients with episodic and chronic migraine. Furthermore, the study aims to compare pressure algometry and Algopeg® measurements and to explore the clinical relevance of mechanosensitivity in specific peripheral nerve regions using a standardized assessment protocol.
Descripción general del estudio
Estado
Condiciones
Intervención / Tratamiento
Tipo de estudio
Inscripción (Estimado)
Contactos y Ubicaciones
Estudio Contacto
- Nombre: Bernhard Taxer, PhD
- Número de teléfono: +436508108217
- Correo electrónico: b.taxer@crcs.at
Ubicaciones de estudio
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Salzburg, Austria, 5020
- Universitätsklinik für Neurologie, neurologische Intensivmedizin und Neurorehabilitation
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Contacto:
- Bernhard Taxer, PhD
- Número de teléfono: +436508108217
- Correo electrónico: b.taxer@crcs.at
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
Método de muestreo
Población de estudio
Descripción
Inclusion Criteria:
- Female and male sex
- Age 18-65 years
- Diagnosis of episodic or chronic migraine according to ICHD-3 criteria (beta version)
- Stable medication regimen (if applicable) for at least 4 weeks prior to inclusion
- Ability to understand study procedures and provide written informed consent
Exclusion Criteria:
- Other primary or secondary headache disorders
- Severe neurological, psychiatric, or systemic diseases
- Pregnancy or breastfeeding
- Participation in another (interventional) study within the last 3 months
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
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Pressure Pain Algometry and neurodynamic testing for mechanical hypersensitivity
Periodo de tiempo: Regarding the observational character of the study the participants are screened in one session expecting a total time frame of 15 minutes on day 1.
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Pressure pain algometry, a psychophysic approach used in quantitatitve sensory testing, is a tool, that can be used to evaluate mechanosensitivity of affected muscles (pressure pain threshold - measured in kg).
We use the classical tool out of QST and compare it with the Algopeg® tool, a calibrated clothespin, not used in regular clinical work so far.
The tool is applied on the index finger for 10 seconds measuring the resulting painful feeling on a numeric rating scale (NRS 0-10).
Neurodynamic testing includes movement maneuvers to assess the mechanosensitivity of the soft tissue of peripheral nerves, explicitly greater occipital nerve and the supraorbital nerve (V1).
Here the outcome mainly relies on the feedback of the participants.
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Regarding the observational character of the study the participants are screened in one session expecting a total time frame of 15 minutes on day 1.
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Colaboradores e Investigadores
Patrocinador
Investigadores
- Investigador principal: Stefan Leis, PD Dr.med., Paracelsus Medical University for Neurology - Christian-Doppler-Klinik Salzburg
Fechas de registro del estudio
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Finalización primaria (Estimado)
Finalización del estudio (Estimado)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- 1063/2026 Migraine_MechSens
Plan de datos de participantes individuales (IPD)
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