Exercise and Dietary Counseling in Improving Physical Activity, Nutrition, and Quality of Life in Older Long-Term Cancer Survivors Who Are Overweight
21 février 2017 mis à jour par: Duke University
RENEW: Reach Out to Enhance Wellness in Older Survivors
RATIONALE: Exercise and dietary counseling may improve physical activity, nutrition, and quality of life in older long-term cancer survivors who are overweight.
PURPOSE: This randomized clinical trial is studying two different schedules of exercise and dietary counseling to compare how well they work in improving physical activity, nutrition, and quality of life in older long-term cancer survivors who are overweight.
Aperçu de l'étude
Statut
Complété
Les conditions
Intervention / Traitement
Description détaillée
OBJECTIVES:
Primary
- Compare the physical function over 1 year of overweight older long-term cancer survivors assigned to immediate vs delayed exercise and dietary counseling.
Secondary
- Compare physical activity, saturated fat and vegetable and fruit intake, body mass index, depression, and general health and well being of experimental arm patients vs control arm patients.
- Evaluate self-efficacy, social support, comorbidity, cancer-type, and gender as factors associated with program efficacy.
- Determine the functional decline over a 2-year period in patients who undergo immediate vs delayed intervention.
- Characterize the mathematical form, over a 2-year period, of physical functioning trajectories among older cancer survivors, including determining if the intervention effects are durable in those who receive the intervention initially and whether "catch-up" is possible in the delayed intervention arm.
OUTLINE: This is a randomized study. Patients are stratified according to cancer type (colorectal vs breast or prostate), sex, age (65-74 years vs 75 years and over), and race (white vs non-white). Patients are randomized to 1 of 2 intervention arms.
- Arm I (immediate intervention): Patients receive a personalized notebook of diet and exercise information, exercise equipment, and logbooks to record food intake and exercise behaviors. Patients undergo 20-minute telephone discussions with a health counselor once weekly for 3 weeks, every 2 weeks for 2 months, and then monthly for up to 1 year for a total of 15 sessions. Patients also undergo a 5-minute telephone survey to assess health every 3 months.
- Arm II (delayed intervention): Patients undergo intervention as in arm I after a 1-year waiting period.
After completion of study intervention, patients are followed periodically for up to 2 years.
PROJECTED ACCRUAL: A total of 640 patients will be accrued for this study.
Type d'étude
Interventionnel
Inscription (Réel)
641
Phase
- Phase 2
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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North Carolina
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Durham, North Carolina, États-Unis, 27705
- Veterans Affairs Medical Center - Durham
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Durham, North Carolina, États-Unis, 27710
- Duke Comprehensive Cancer Center
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
65 ans à 120 ans (Adulte plus âgé)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Tout
La description
DISEASE CHARACTERISTICS:
Diagnosed colorectal, prostate, or female breast cancer
- At least 5 years beyond date of diagnosis with no clinical evidence of progressive disease or second primaries
- Body mass index ≥ 25 kg/m^2 and < 40 kg/m^2
- Currently exercising < 150 minutes/week
- Hormone receptor status not specified
PATIENT CHARACTERISTICS:
- Menopausal status not specified
No serious intercurrent medical condition or disability that could preclude study treatment, including any of the following:
- Severe orthopedic condition or scheduled hip or knee replacement within the next 6 months
- Paralysis
- End-stage renal disease
- Dementia
- Unstable angina
- Heart attack, congestive heart failure, or pulmonary condition that required oxygen or hospitalization within the past 6 months
- Ability to read, write, and speak English
PRIOR CONCURRENT THERAPY:
- No concurrent warfarin
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Autre
- Répartition: Randomisé
- Modèle interventionnel: Affectation croisée
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Aucune intervention: Wait-list control
Wait-list control received diet & exercise counseling during year 2 as a courtesy
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|
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Expérimental: Lifestyle counseling
subjects randomized to receive diet & exercise counseling for one year
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Physical function as assessed by Short-Form Health Survey (SF-36) with physical function subscale and late effects lower body subscales at baseline and years 1 and 2 following study completion
Délai: one year
|
one year for intervention subjects - in year two, wait listed controls received intervention and the intervention subjects were followed.
|
one year
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Quality of life as assessed by SF-36 at baseline and years 1 and 2 following study completion
Délai: one year
|
one year for intervention subjects - in year two, wait listed controls received intervention and the intervention subjects were followed.
|
one year
|
|
Physical activity as assessed by Community Healthy Activities Model Program for Seniors (CHAMPS) at baseline and years 1 and 2 following study completion
Délai: one year
|
one year for intervention subjects - in year two, wait listed controls received intervention and the intervention subjects were followed.
|
one year
|
|
Dietary intake as assessed by 2-day dietary recalls at baseline and years 1 and 2 following study completion
Délai: one year
|
one year for intervention subjects - in year two, wait listed controls received intervention and the intervention subjects were followed.
|
one year
|
|
Body weight status as assessed by body mass index at baseline and years 1 and 2 following study completion
Délai: one year
|
one year for intervention subjects - in year two, wait listed controls received intervention and the intervention subjects were followed.
|
one year
|
|
Depression and/or anxiety as assessed by Hospital Anxiety Depression Scale at baseline and years 1 and 2 following study completion
Délai: one year
|
one year for intervention subjects - in year two, wait listed controls received intervention and the intervention subjects were followed.
|
one year
|
|
Self-efficacy for exercise and dietary change assessed by self-efficacy algorithms at baseline and years 1 and 2 following study completion
Délai: one year
|
one year for intervention subjects - in year two, wait listed controls received intervention and the intervention subjects were followed.
|
one year
|
|
Stage of readiness for exercise and dietary change as assessed by the stage of change algorithms at baseline and years 1 and 2 following study completion
Délai: one year
|
one year for intervention subjects - in year two, wait listed controls received intervention and the intervention subjects were followed.
|
one year
|
Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Collaborateurs
Les enquêteurs
- Chaise d'étude: Wendy Demark-Wahnefried, PhD, Duke Cancer Institute
Publications et liens utiles
La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.
Publications générales
- Demark-Wahnefried W, Morey MC, Sloane R, Snyder DC, Cohen HJ. Promoting healthy lifestyles in older cancer survivors to improve health and preserve function. J Am Geriatr Soc. 2009 Nov;57 Suppl 2(Suppl 2):S262-4. doi: 10.1111/j.1532-5415.2009.02507.x.
- Morey MC, Blair CK, Sloane R, Cohen HJ, Snyder DC, Demark-Wahnefried W. Group trajectory analysis helps to identify older cancer survivors who benefit from distance-based lifestyle interventions. Cancer. 2015 Dec 15;121(24):4433-40. doi: 10.1002/cncr.29684. Epub 2015 Oct 29.
- Mosher CE, Sloane R, Morey MC, Snyder DC, Cohen HJ, Miller PE, Demark-Wahnefried W. Associations between lifestyle factors and quality of life among older long-term breast, prostate, and colorectal cancer survivors. Cancer. 2009 Sep 1;115(17):4001-9. doi: 10.1002/cncr.24436.
- Demark-Wahnefried W, Morey MC, Sloane R, Snyder DC, Miller PE, Hartman TJ, Cohen HJ. Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors. J Clin Oncol. 2012 Jul 1;30(19):2354-61. doi: 10.1200/JCO.2011.40.0895. Epub 2012 May 21.
- Miller PE, Morey MC, Hartman TJ, Snyder DC, Sloane R, Cohen HJ, Demark-Wahnefried W. Dietary patterns differ between urban and rural older, long-term survivors of breast, prostate, and colorectal cancer and are associated with body mass index. J Acad Nutr Diet. 2012 Jun;112(6):824-31, 831.e1. doi: 10.1016/j.jand.2012.02.021.
- Morey MC, Snyder DC, Sloane R, Cohen HJ, Peterson B, Hartman TJ, Miller P, Mitchell DC, Demark-Wahnefried W. Effects of home-based diet and exercise on functional outcomes among older, overweight long-term cancer survivors: RENEW: a randomized controlled trial. JAMA. 2009 May 13;301(18):1883-91. doi: 10.1001/jama.2009.643.
- Snyder DC, Morey MC, Sloane R, Stull V, Cohen HJ, Peterson B, Pieper C, Hartman TJ, Miller PE, Mitchell DC, Demark-Wahnefried W. Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW): design, methods and recruitment challenges of a home-based exercise and diet intervention to improve physical function among long-term survivors of breast, prostate, and colorectal cancer. Psychooncology. 2009 Apr;18(4):429-39. doi: 10.1002/pon.1491.
- Winger JG, Mosher CE, Rand KL, Morey MC, Snyder DC, Demark-Wahnefried W. Diet and exercise intervention adherence and health-related outcomes among older long-term breast, prostate, and colorectal cancer survivors. Ann Behav Med. 2014 Oct;48(2):235-45. doi: 10.1007/s12160-014-9598-7.
- Blair CK, Morey MC, Desmond RA, Cohen HJ, Sloane R, Snyder DC, Demark-Wahnefried W. Light-intensity activity attenuates functional decline in older cancer survivors. Med Sci Sports Exerc. 2014 Jul;46(7):1375-83. doi: 10.1249/MSS.0000000000000241.
- Miller P, Demark-Wahnefried W, Snyder DC, Sloane R, Morey MC, Cohen H, Kranz S, Mitchell DC, Hartman TJ. Dietary supplement use among elderly, long-term cancer survivors. J Cancer Surviv. 2008 Sep;2(3):138-48. doi: 10.1007/s11764-008-0060-3. Epub 2008 Jul 11.
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude
1 décembre 2003
Achèvement primaire (Réel)
1 juin 2008
Achèvement de l'étude (Réel)
1 mai 2009
Dates d'inscription aux études
Première soumission
15 mars 2006
Première soumission répondant aux critères de contrôle qualité
15 mars 2006
Première publication (Estimation)
17 mars 2006
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
23 février 2017
Dernière mise à jour soumise répondant aux critères de contrôle qualité
21 février 2017
Dernière vérification
1 février 2013
Plus d'information
Termes liés à cette étude
Mots clés
- cancer du sein de stade IV
- cancer du sein stade IIIA
- cancer du sein récurrent
- cancer du sein stade IIIB
- cancer de la prostate stade III
- cancer de la prostate stade IV
- cancer de la prostate récurrent
- cancer du rectum stade IV
- cancer du côlon stade IV
- cancer récurrent du côlon
- cancer du rectum récurrent
- cancer du côlon stade III
- cancer du sein de stade II
- cancer du sein stade IIIC
- cancer du sein de stade I
- cancer de la prostate stade I
- cancer de la prostate stade IIB
- cancer de la prostate stade IIA
- cancer du rectum stade II
- cancer du rectum stade III
- cancer du côlon stade II
- cancer du rectum stade I
- cancer du côlon stade I
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- Pro00012963
- DUMC-5477-03-12R0ER
- DUMC-5477-04-12R1ER
- CDR0000460231 (Autre identifiant: NCI)
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .
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