Early Detection of Cardiac Toxicity in Childhood Cancer Survivors

Inclusion Criteria:

• Subjects that have received anthracycline based chemotherapy
• Age: 8 years old - 25 years old
• Subjects that do not require sedation for cardiac MRI.
• Subjects must have completed treatment in the last 10 years

Exclusion Criteria:

• Patients with significant congenital heart defects
• Patients with renal injury or renal failure, defined as an estimated glomerular filtration rate [eGFR] <30 ml/min/1.73 m2 body surface area), as previously calculated)
• Patients that require sedation for a cardiac MRI
• Subjects that are pregnant or lactating
• Patients with contraindications to a cardiac MRI:
• Cardiac pacemaker or implantable defibrillator
• Cerebral aneurysm clip
• Neural stimulator
• Metallic ocular foreign body
• Any implanted device (i.e. insulin pump, drug infusion device)
• Claustrophobia
• Metal shrapnel or bullet
• Investigator assessment of inability to comply with protocol
• Unable/unwilling to lie still throughout the research procedure
• Persons with cognitive impairment