"SCRIBBLE" Valutazione longitudinale del biomarcatore del sangue della lesione del midollo spinale (SCRIBBLE)

All participants for this study will be recruited at Vancouver General Hospital. The study will include two groups/cohorts:

SCI Subjects. Patients who suffer a traumatic spinal cord injury who meet the following inclusion criteria are eligible for admission into the study as "SCI subjects":

Non-SCI Spine Trauma Control Subjects. Patients who suffer a fracture or dislocation of their spinal column but without neurologic injury are eligible for admission into the study as "Non-SCI Spine Trauma Control Subjects" if they meet the following inclusion criteria:

Inclusion Criteria

SCI Participants. Patients who suffer a traumatic spinal cord injury who meet the following inclusion criteria are eligible for admission into the study as "SCI participants":

• Male or Female ≥ 19 years of age
• Blunt (non-penetrating) traumatic spinal cord injury
• Baseline neurologic impairment deemed "complete"(AIS A) or "incomplete" (AIS B, C, D)
• Bony spinal level involvement between C0 and L1 inclusive
• Ability to have initial blood sample drawn within 24 hours of injury
• Have either an arterial line, central line, or intravenous line for collecting blood samples
• Able and willing to provide informed consent

Non-SCI Spine Trauma Control Participants. Patients who suffer a fracture or dislocation of their spinal column without neurologic injury who meet the following inclusion criteria are eligible for admission into the study as "Non-SCI Spine Trauma Control Participants":

• Male or Female ≥ 19 years of age
• Traumatic spinal fracture between C0 and L1 without spinal cord injury
• Collection of initial blood sample within 24 hours of injury
• Have either an arterial line, central line, or intravenous line for collecting blood samples
• Able and willing to provide informed consent

Exclusion Criteria

Patients who fulfill any of the following criteria are not eligible for admission into the study:

• Penetrating spinal cord injury (e.g. gunshot, stab)
• Spinal cord injury with sensory deficit only (i.e. no motor deficit)
• Spinal injury below L1
• Isolated radiculopathy without fracture
• Isolated cauda equina injury
• Pre-existing thromboembolic disease or coagulopathy (disorders related to blood clotting), such as haemophilia or von Willebrand's disease
• Have any other medical condition that in the investigator's opinion would render the study procedures dangerous or impair their ability to receive treatment