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Effectiveness of the Personalized Responses & Integrated Systems for Metabolism (PRISM) on Improving Insulin Resistance Among Adults With Metabolic Syndrome: A Pilot Study (PRISM-I) (PRISM-I)

15 luglio 2026 aggiornato da: Jocelyn Chew, National University Health System, Singapore
The primary objective of the Personalized Responses & Integrated Systems for Metabolism (PRISM-I) pilot study is to assess the feasibility of conducting a definitive randomized controlled trial evaluating precision lifestyle interventions for improving insulin resistance in adults with metabolic syndrome.

Panoramica dello studio

Stato

Non ancora reclutamento

Condizioni

Intervento / Trattamento

Descrizione dettagliata

Specific objectives are to:

  1. Evaluate the feasibility and acceptability of the PRISM intervention and study procedures, including participant recruitment, retention, adherence, intervention delivery, and digital platform usability.
  2. Explore the preliminary effects of the four lifestyle interventions (time-restricted eating, increased physical activity, low-glycaemic load diet, and sleep hygiene) on insulin resistance, measured using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).
  3. Examine the preliminary effects of the interventions on biochemical, anthropometric, behavioural, cognitive, and psychological outcomes.
  4. Explore the potential behavioural and physiological pathways through which the lifestyle interventions may influence insulin resistance to inform the design of the definitive PRISM trial.

Tipo di studio

Interventistico

Iscrizione (Stimato)

200

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Contatto studio

Luoghi di studio

  • Singapore
      • Singapore, Singapore, 117597
        • National University of Singapore

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

  • Adulto
  • Adulto più anziano

Accetta volontari sani

No

Descrizione

Inclusion Criteria:

Participants will be included for if they are:

  • (1) adults aged 21-70 years old;
  • (2) willing and able to comply with using a CGM, smart ring, food logging app
  • (3) able to provide written informed consent;
  • (4) English-speaking and literate;
  • (5) meet the inclusion criteria for metabolic syndrome and insulin resistance.
  • The criteria for insulin resistance is HOMA-IR ≥ 2.5.
  • The criteria for metabolic syndrome is to have high waist circumference (≥ 80cm for females and ≥ 90cm for males); and any two of the four below:
  • (1) raised triglycerides: 1.7 mmol/L or on treatment;
  • (2) reduced HDL cholesterol: < 1.0 mmol/L (40 mg/dL) in men, < 1.3 mmol/L (50 mg/dL) in women, or on treatment;
  • (3) high blood pressure: 130/85 mmHg or on treatment; or
  • (4) raised fasting glucose: 5.6 mmol/L (100 mg/dL) or previously diagnosed with T2DM

Exclusion Criteria:

Participants will be excluded from both phases if they are:

  • (1) on insulin therapy;
  • (2) are pregnant or lactating;
  • (3) have a medical condition or are on a treatment that may interfere with study participation or metabolic assessments, as determined by the study investigators;
  • (4) currently participating in other lifestyle modification programs.

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Trattamento
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Separare

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Nessun intervento: Control
At baseline, participants will undergo blood collection, stool sample collection, questionnaires, and cognitive and physical assessments. They will be provided with an Oura Ring and continuous glucose monitor (CGM) to monitor physiological and behavioral measures throughout the study. Participants will use the eTRIP© app to log meals and the Oura app to record physical activity. General healthy lifestyle information on diet, physical activity, and sleep will be provided at baseline. Participants assigned to the control group will continue their usual lifestyle throughout the 10-week study and will not receive any targeted lifestyle intervention. At Week 5, participants will attend a study visit for interim assessments and replacement of the CGM for the remainder of the study. Baseline assessments will be repeated at Week 10.
Sperimentale: PRISM
At baseline, participants will undergo blood collection, stool sample collection, questionnaires, and cognitive and physical assessments. They will be provided with an Oura Ring and continuous glucose monitor (CGM) to monitor physiological and behavioural measures throughout the study. Participants will use the eTRIP© app to log meals and the Oura app to record physical activity. General healthy lifestyle advice on diet, physical activity, and sleep will be provided at baseline. At the end of the 2-week baseline assessment, participants will be randomized to one of four lifestyle interventions: time-restricted eating, increased physical activity, a low-glycemic load diet, or sleep hygiene. At Week 5, participants will attend a study visit and be randomized to receive an additional intervention from one of the remaining three lifestyle domains, beginning in Week 6. Baseline assessments will be repeated at Week 10.
Comportamentale: Time-restricted eating
Following a 2-week baseline assessment, participants will begin a time-restricted eating (TRE) intervention by consuming all meals within a self-selected 8-hour eating window and fasting for the remaining 16 hours each day. They will measure blood ketone levels daily before breaking their fast using a glucometer. At Week 6, participants will be randomly assigned an additional lifestyle intervention (physical activity, low glycemic load diet, or sleep hygiene).
Comportamentale: Physical Activity
Following a 2-week baseline assessment, participants will begin a physical activity intervention. They will be instructed to complete home-based resistance training three times per week and aerobic interval training twice per week using a guided exercise programme. Exercise sessions will be performed independently without direct supervision. Participants will also be encouraged to aim for at least 8,000 steps daily, take a 15-minute walk after lunch and dinner where feasible, and break up prolonged sitting every 30-60 minutes with light movement or standing. At Week 6, participants will be randomly assigned an additional lifestyle intervention (time-restricted eating, low-glycemic load diet, or sleep hygiene).
Comportamentale: Low Glycemic Load diet
Following a 2-week baseline assessment, participants will begin a low-glycaemic load (GL) diet intervention. They will be instructed to replace high-GL foods with lower-GL alternatives, reduce their intake of refined carbohydrates, sugary foods and beverages, and ultra-processed foods, and follow healthy meal composition and meal sequencing principles. At Week 6, participants will be randomly assigned an additional lifestyle intervention (time-restricted eating, physical activity, or sleep hygiene).
Comportamentale: Sleep hygiene
Following a 2-week baseline assessment, participants will begin a sleep hygiene intervention. They will be instructed to adopt healthy sleep habits, including maintaining a regular sleep schedule with adequate sleep duration, practicing good bedtime routines, and optimizing the sleep environment to improve sleep quality. At Week 6, participants will be randomly assigned an additional lifestyle intervention (time-restricted eating, physical activity, or a low-glycemic load diet).

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)
Lasso di tempo: At baseline, Week 10

Insulin resistance will be assessed using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), calculated as:

HOMA-IR = (fasting plasma insulin × fasting plasma glucose) / 22.5

Higher HOMA-IR values indicate greater insulin resistance, whereas lower values indicate improved insulin sensitivity (reduced insulin resistance).
At baseline, Week 10

Misure di risultato secondarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Glycated haemoglobin (HbA1c) (%)
Lasso di tempo: At baseline, Week 10
Glycated haemoglobin (HbA1c) reflects average blood glucose levels over the preceding two to three months and is measured using standard laboratory blood analysis. Higher values indicate poorer long-term glycaemic control.
At baseline, Week 10
Fasting plasma glucose (mmol/L)
Lasso di tempo: At baseline, Week 10
Fasting blood glucose is a biochemical measure of blood glucose concentration after an overnight fast, measured using standard laboratory blood analysis. Higher values indicate poorer glycaemic control.
At baseline, Week 10
Fasting Insulin (µIU/mL)
Lasso di tempo: At baseline, Week 10
Fasting plasma insulin is a biochemical marker measured using standard laboratory blood analysis following an overnight fast. Higher values indicate greater insulin resistance and impaired glucose metabolism.
At baseline, Week 10
Total cholesterol (mmol/L)
Lasso di tempo: At baseline, Week 10
Total cholesterol is a lipid biomarker measured using standard laboratory blood analysis to assess overall blood cholesterol levels. Higher values indicate poorer lipid profiles and increased cardiometabolic risk.
At baseline, Week 10
High-density lipoprotein cholesterol (HDL-C) (mmol/L)
Lasso di tempo: At baseline, Week 10
High-density lipoprotein cholesterol (HDL-C) is a lipid biomarker measured using standard laboratory blood analysis to assess protective cholesterol levels. Lower values indicate poorer lipid profiles and increased cardiometabolic risk.
At baseline, Week 10
Low-density lipoprotein cholesterol (LDL-C) (mmol/L)
Lasso di tempo: At baseline, Week 10
Low-density lipoprotein cholesterol (LDL-C) is a lipid biomarker measured using standard laboratory blood analysis to assess atherogenic cholesterol levels. Higher values indicate poorer lipid profiles and increased cardiovascular risk.
At baseline, Week 10
Cholesterol/HDL ratio
Lasso di tempo: At baseline, Week 10
The total cholesterol to HDL cholesterol ratio is calculated from standard laboratory blood analysis and is used to assess cardiovascular risk. Higher values indicate a poorer lipid profile and increased cardiometabolic risk.
At baseline, Week 10
Triglycerides (mmol/L)
Lasso di tempo: At baseline, Week 10
Triglycerides are a lipid biomarker measured using standard laboratory blood analysis to assess circulating triglyceride levels. Higher values indicate poorer lipid profiles and increased cardiometabolic risk.
At baseline, Week 10
Lipoprotein a (nmol/L)
Lasso di tempo: At baseline, Week 10
Lipoprotein(a) is an advanced lipid biomarker measured using standard laboratory blood analysis to assess inherited cardiovascular risk. Higher values are associated with increased risk of atherosclerotic cardiovascular disease
At baseline, Week 10
Apolipoprotein A1 (g/L)
Lasso di tempo: At baseline, Week 10
Apolipoprotein A1 (ApoA1) is a lipid biomarker measured using standard laboratory blood analysis to assess the major protein component of HDL cholesterol. Higher values generally indicate a more favourable lipid profile.
At baseline, Week 10
Apolipoprotein B (g/L)
Lasso di tempo: At baseline, Week 10
Apolipoprotein B (ApoB) is a lipid biomarker measured using standard laboratory blood analysis to assess the number of atherogenic lipoprotein particles. Higher values indicate increased cardiovascular risk.
At baseline, Week 10
Apolipoprotein B/ A1 ratio
Lasso di tempo: At baseline, Week 10
The Apolipoprotein B/A1 ratio is calculated from standard laboratory blood analysis and reflects the balance between atherogenic and protective lipoproteins. Higher values indicate increased cardiovascular risk
At baseline, Week 10
High-sensitivity C-reactive protein (hs-CRP) (mg/L)
Lasso di tempo: At baseline, Week 10
High-sensitivity C-reactive protein (hs-CRP) is an inflammatory biomarker measured using standard laboratory blood analysis to assess low-grade systemic inflammation. Higher values indicate greater systemic inflammation and increased cardiometabolic risk.
At baseline, Week 10
Total protein (g/L)
Lasso di tempo: At baseline, Week 10
Total protein is measured using standard laboratory blood analysis to assess the combined concentration of albumin and globulins in blood.
At baseline, Week 10
Albumin (g/L)
Lasso di tempo: At baseline, Week 10
Albumin is a plasma protein measured using standard laboratory blood analysis to assess nutritional status and liver function. Lower values may indicate impaired liver function, malnutrition, or inflammation.
At baseline, Week 10
Globulin (g/L)
Lasso di tempo: At baseline, Week 10
Globulin is measured using standard laboratory blood analysis to assess immune and inflammatory proteins in the blood.
At baseline, Week 10
A/G ratio
Lasso di tempo: At baseline, Week 10
The albumin-to-globulin (A/G) ratio is calculated from serum albumin and globulin concentrations and is used to assess liver function, nutritional status, and inflammatory conditions.
At baseline, Week 10
Bilirubin (µmol/L)
Lasso di tempo: At baseline, Week 10
Bilirubin is measured using standard laboratory blood analysis to assess liver function and bilirubin metabolism.
At baseline, Week 10
Alkaline phosphatase (ALP) (U/L)
Lasso di tempo: At baseline, Week 10
Alkaline phosphatase (ALP) is a liver enzyme measured using standard laboratory blood analysis to assess liver and biliary tract function.
At baseline, Week 10
Alanine aminotransferase (ALT/SGPT) (U/L)
Lasso di tempo: At baseline, Week 10
Alanine aminotransferase (ALT/SGPT) is a liver enzyme measured using standard laboratory blood analysis to assess liver cell injury.
At baseline, Week 10
Aspartate aminotransferase (AST/SGOT) (U/L)
Lasso di tempo: At baseline, Week 10
Aspartate aminotransferase (AST/SGOT) is a liver enzyme measured using standard laboratory blood analysis to assess liver and muscle cell injury. Higher values may indicate liver damage or other tissue injury.
At baseline, Week 10
Blood pressure (mmHg)
Lasso di tempo: At baseline, Week 10
Both systolic and diastolic blood pressure will be assessed.
At baseline, Week 10
Montreal Cognitive Assessment (MoCA)
Lasso di tempo: At baseline, Week 10
The Montreal Cognitive Assessment is a validated screening instrument designed to detect mild cognitive impairment. It assesses multiple cognitive domains, including attention and concentration, executive function, memory, language, visuospatial skills, abstraction, calculation, and orientation. Total scores range from 0 to 30, with higher scores indicating better cognitive function.
At baseline, Week 10
Hand grip strength (kg)
Lasso di tempo: At baseline, Week 10
Hand grip strength will be measured using a Jamar dynamometer as an indicator of muscle strength. Higher values indicate greater muscle strength.
At baseline, Week 10
Weight (kg)
Lasso di tempo: At baseline, Weeks 5,10
At baseline, Weeks 5,10
Waist circumference (cm)
Lasso di tempo: At baseline, Weeks 5,10
At baseline, Weeks 5,10
Body mass index (BMI) (kg/m²)
Lasso di tempo: At baseline, Weeks 5,10
Body mass index (BMI) will be calculated as weight (kg)/height² (m²). Lower values indicate lower overall adiposity.
At baseline, Weeks 5,10
Percentage Body Fat (%)
Lasso di tempo: At baseline, Weeks 5,10
Percentage body fat will be estimated using bioelectrical impedance analysis (InBody 120). Lower values indicate lower adiposity.
At baseline, Weeks 5,10
Body Fat Mass (kg)
Lasso di tempo: At baseline, Weeks 5,10
Measured using InBody 120.
At baseline, Weeks 5,10
Visceral Fat Level
Lasso di tempo: At baseline, Week 10
Visceral fat level will be estimated using bioelectrical impedance analysis (InBody 120). Lower values indicate reduced visceral adiposity.
At baseline, Week 10
ABSI (body shape index)
Lasso di tempo: At baseline, Weeks 5,10
A Body Shape Index (ABSI) is calculated from waist circumference, height, and body weight to assess central adiposity independently of BMI. Higher values indicate greater abdominal obesity and cardiometabolic risk.
At baseline, Weeks 5,10
BRI (body roundness index)
Lasso di tempo: At baseline, Weeks 5,10
Body Roundness Index (BRI) is calculated from height and waist circumference to estimate body fat distribution and central adiposity. Higher values indicate greater abdominal adiposity and cardiometabolic risk.
At baseline, Weeks 5,10
Three Factor Eating Questionnaire (TFEQ)
Lasso di tempo: At baseline, Week 10
The Three-Factor Eating Questionnaire-Revised 18 is a validated self-administered instrument used to assess eating-related behaviours. It measures three domains: cognitive restraint, uncontrolled eating, and emotional eating. Scores are calculated separately for each domain and transformed to a 0-100 scale, with higher scores indicating greater levels of the respective eating behaviour.
At baseline, Week 10
International Physical Activity Questionnaire Short-Form (IPAQ-SF)
Lasso di tempo: At baseline, Week 10
The International Physical Activity Questionnaire - Short Form is a validated self-administered questionnaire used to assess self-reported physical activity levels over the previous 7 days. It captures the frequency and duration of walking, moderate-intensity activity, vigorous-intensity activity, and time spent sitting. Responses are used to calculate total physical activity expressed as MET-minutes/week. There is no fixed minimum or maximum score; higher MET-minutes/week indicate higher levels of physical activity.
At baseline, Week 10
Generalized Anxiety Disorder 7-item (GAD-7)
Lasso di tempo: At baseline, Week 10
The Generalized Anxiety Disorder 7-item questionnaire is a validated self-administered screening instrument used to assess the frequency of anxiety symptoms over the previous 2 weeks. Total scores range from 0 to 21, with higher scores indicating greater anxiety symptom severity.
At baseline, Week 10
Patient Health Questionnaire-9 (PHQ-9)
Lasso di tempo: At baseline, Week 10
The Patient Health Questionnaire-9 is a validated self-administered screening instrument used to assess the frequency of depressive symptoms over the previous 2 weeks. Total scores range from 0 to 27, with higher scores indicating greater depressive symptom severity.
At baseline, Week 10
Perceived Stress Scale (PSS-10)
Lasso di tempo: At baseline, Week 10
The Perceived Stress Scale-10 is a validated self-administered questionnaire used to assess the degree to which individuals perceive situations in their lives as stressful over the previous month. Total scores range from 0 to 40, with higher scores indicating greater perceived stress.
At baseline, Week 10
Big Five Inventory - 44 item (BFI-44)
Lasso di tempo: At baseline, Week 10
The Big Five Inventory-44 is a validated self-administered questionnaire used to assess personality across five domains: openness, conscientiousness, extraversion, agreeableness, and neuroticism. Scores are calculated separately for each domain; there is no overall total score. Domain scores are typically calculated as the mean of the items within each domain and range from 1 to 5, with higher scores indicating greater expression of the respective personality trait. As this is a descriptive measure of personality, higher scores do not represent universally better or worse outcomes.
At baseline, Week 10
Sleep Hygiene Index (SHI)
Lasso di tempo: At baseline, Week 10
The Sleep Hygiene Index is a validated 13-item self-administered questionnaire that assesses behaviours associated with sleep hygiene. Total scores range from 13 to 65, with higher scores indicating poorer sleep hygiene practices.
At baseline, Week 10
Gut microbiome
Lasso di tempo: At baseline, Week 10
At baseline, Week 10
Resting heart rate (beats/min)
Lasso di tempo: Baseline through Week 10
Resting heart rate measured using the Oura Ring. Resting heart rate represents the average heart rate during periods of rest. Lower values generally indicate better cardiovascular fitness.
Baseline through Week 10
Heart rate variability (ms)
Lasso di tempo: Baseline through Week 10
Heart rate variability measured using the Oura Ring. HRV reflects variation in the time interval between successive heartbeats and is an indicator of autonomic nervous system function. Higher values generally indicate better autonomic regulation and recovery.
Baseline through Week 10
Heart rate recovery (beats/min)
Lasso di tempo: Baseline through Week 10
Heart rate recovery measured using the Oura Ring. Heart rate recovery represents the reduction in heart rate following physical activity and reflects cardiovascular recovery capacity. Higher values indicate faster recovery and better cardiovascular fitness.
Baseline through Week 10
Sleep duration (hours)
Lasso di tempo: Baseline through Week 10
Sleep duration measured using the Oura Ring. Sleep duration represents the total amount of sleep obtained per night. Higher values generally indicate longer sleep duration.
Baseline through Week 10
Sleep quality score (0-100)
Lasso di tempo: Baseline through Week 10
Sleep quality score measured using the Oura Ring. Scores range from 0 to 100, with higher scores indicating better sleep quality.
Baseline through Week 10
Daily step count (steps/day)
Lasso di tempo: Baseline through Week 10
Daily step count measured using the Oura Ring. Step count represents the total number of steps accumulated per day. Higher values indicate greater daily physical activity.
Baseline through Week 10
Activity intensity minutes (minutes/day)
Lasso di tempo: Baseline through Week 10
Activity intensity minutes measured using the Oura Ring. This metric represents the daily duration of moderate-to-vigorous physical activity. Higher values indicate greater participation in physical activity.
Baseline through Week 10
Energy expenditure (kcal/day)
Lasso di tempo: Baseline through Week 10
Energy expenditure measured using the Oura Ring. This metric represents the estimated daily energy expenditure from physical activity. Higher values indicate greater energy expenditure.
Baseline through Week 10
Mean glucose (mmol/L)
Lasso di tempo: Baseline through Week 10
Mean glucose concentration measured using continuous glucose monitoring. Mean glucose represents the average glucose concentration over the monitoring period. Lower values generally indicate better glycaemic control.
Baseline through Week 10
Coefficient of variation (%)
Lasso di tempo: Baseline through Week 10
Coefficient of variation of glucose measured using continuous glucose monitoring. CV reflects glucose variability relative to mean glucose concentration. Lower values indicate more stable glucose levels and better glycaemic control.
Baseline through Week 10
Time Below Range (TBR, %)
Lasso di tempo: Baseline through Week 10
Percentage of time spent below the target glucose range (<3.9 mmol/L), measured using continuous glucose monitoring. Lower values indicate less time spent in hypoglycaemia and better glycaemic control.
Baseline through Week 10
Time In Range (TIR, %)
Lasso di tempo: Baseline through Week 10
Percentage of time spent within the target glucose range (3.9-10.0 mmol/L), measured using continuous glucose monitoring. Higher values indicate better glycaemic control.
Baseline through Week 10
Time Above Range (TAR, %)
Lasso di tempo: Baseline through Week 10
Percentage of time spent above the target glucose range (>10.0 mmol/L), measured using continuous glucose monitoring. Lower values indicate less hyperglycaemia and better glycaemic control.
Baseline through Week 10
Postprandial glucose excursion (PPGE) (mmol/L)
Lasso di tempo: Baseline through Week 10
Postprandial glucose excursion measured using continuous glucose monitoring. PPGE is calculated as the difference between peak glucose concentration and pre-meal glucose concentration within 2 hours after the start of a meal. Higher values indicate greater postprandial glucose excursions.
Baseline through Week 10
Incremental Area Under the Curve (iAUC, mmol/L·min)
Lasso di tempo: Baseline through Week 10
Incremental area under the glucose curve measured using continuous glucose monitoring. iAUC represents the area under the glucose curve above the pre-meal baseline during the 2-hour period following a meal. Higher values indicate greater overall postprandial glucose exposure.
Baseline through Week 10

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

National University Health System, Singapore

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Stimato)

1 luglio 2026

Completamento primario (Stimato)

1 luglio 2027

Completamento dello studio (Stimato)

1 luglio 2027

Date di iscrizione allo studio

Primo inviato

2 luglio 2026

Primo inviato che soddisfa i criteri di controllo qualità

15 luglio 2026

Primo Inserito (Effettivo)

17 luglio 2026

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

17 luglio 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

15 luglio 2026

Ultimo verificato

1 luglio 2026

Maggiori informazioni

Termini relativi a questo studio

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • NUS-IRB-2026-0409

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

NO

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

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