Mothers and Babies at Yorkhill Thyroid Health Cohort (MABY)
Giving Children the Best Start in Life: the Mothers and Babies at Yorkhill Thyroid Health
調査の概要
詳細な説明
Iodine is a critical component of thyroid hormones, which are essential for normal growth, and brain development, most of the latter occurring during fetal life and in the first three years of life. Maternal dietary iodine is the sole source for fetuses and for exclusively breastfed infants. Recent evidence indicates that the UK female population is not iodine sufficient. Thus a significant proportion of UK pregnant women will also be insufficient in dietary iodine with potential harmful consequences for their babies. We wish to investigate the relationship between maternal iodine status (sufficient versus insufficient) in pregnancy, the mode of neonatal feeding (exclusively breast fed vs exclusively formula fed); and the effect this has on the functioning of the newborn baby's thyroid gland, with provision for later cognitive followup assessment. In order to do this, we will determine:
i) the iodine status of the mother during pregnancy and in the immediate postnatal period (dietary and urinary) and the newborn infant (urinary), ii) the thyroid function of the mother (thyroid stimulating hormone, thyroglobulin, T4 in serum during pregnancy, and thyroid stimulating hormone and thyroglobulin in dried blood spots postpartum) and infant (thyroid stimulating hormone in dried blood spots collected during a routine procedure).
Our hypothesis is that babies whose mothers are iodine insufficient will show higher levels of TSH and thyroglobulin than the babies of iodine sufficient mothers.
研究の種類
入学 (予想される)
連絡先と場所
研究場所
-
-
-
Glasgow、イギリス
- 募集
- NHS GGC Community midwifery units
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-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Healthy pregnant women
- Able to read, write and speak in English
- Attending a Greater Glasgow and Clyde maternity unit
Exclusion Criteria:
- Abnormal pregnancies.
- Mothers with known thyroid disorders.
- Preterm infants (born before 37 completed weeks).
- Multiple births.
- Infants with postnatal problems such as infection or malformation.
研究計画
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
---|---|
mothers and babies
pregnant mothers (UK resident) and their babies (observational, not an intervention)
|
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
thyroid function of mothers (measurement of TSH and Tg)
時間枠:up to 38 week gestation
|
measurement of TSH and Tg
|
up to 38 week gestation
|
thyroid function of infant (routine TSH measurement)
時間枠:Day 4 of life
|
routine TSH measurement
|
Day 4 of life
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Iodine status of mothers (iodine intake and excretion)
時間枠:up to 38 week gestation
|
iodine status defined by iodine intake and excretion
|
up to 38 week gestation
|
Iodine status of infant (iodine intake and excretion)
時間枠:Day 4 of life
|
iodine status defined by iodine intake and excretion
|
Day 4 of life
|
Iodine level in hair and breastmilk
時間枠:after birth
|
measurement of iodine in hair and breastmilk
|
after birth
|
協力者と研究者
スポンサー
捜査官
- 主任研究者:Filiz Cizmecioglu、University of Glasgow
- スタディディレクター:Emilie Combet、University of Glasgow
- 主任研究者:Jeremy Jones、University of Glasgow
- 主任研究者:Malcolm Donaldson、University of Glasgow
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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