Illeostomist의 병아리 콩 식사에서 생체 이용률?
병아리 콩 식사로부터 다량 영양소 및 생물 활성 화합물의 생체 이용률 : 회장 절개 연구.
The matrix of a food can significantly affect how well humans can absorb and use nutrients. Plants like fruits, vegetables, nuts, grains, and legumes have cell walls that form a network around their cells. These cell walls are a barrier for the digestive system to break down completely, which can make it harder to digest the food and get energy from it. This study will explore how the integrity of plant cell walls affects how well humans can absorb macronutrients (protein, fat and carbohydrates) and beneficial compounds e.g. phytochemicals. The study will compare two chickpea meals that have similar nutrients and energy content but differ in the amount of intact plant cell walls e.g. chickpea salad meal (INTACT diet) and chickpea burger meal (BROKEN diet).
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
상세 설명
The energy content of food can be in principle calculated by multiplying the content of each energy-yielding substrate by the corresponding heat of combustion. However, only part of this energy yielding substrates is converted to energy because of their incomplete digestion and absorption in the gastrointestinal tract. The structural composition of foods, known as the food matrix, significantly affects nutrient bioavailability. One such structural feature is the integrity of plant tissues characterised by the interconnected, continuous network of cell walls which surround and protect plant cells. When cellular integrity is retained, macronutrients are naturally "encapsulated" within cell walls which effectively reduces the rate and the extent of their digestibility by 6-7% compared to a diet poor in plant-based foods. This study aims to investigate the effect of plant tissue integrity on the total energy excretion of a diet, bioavailability of macronutrients and bioactive compounds, and on plasma levels of glucose, essential amino acids and triglycerides. The investigators will do this by comparing two diets which have (approximately) the same composition in macronutrients and energy but different levels of plant tissues integrity, namely a diet rich in intact plant tissues (INTACT diet), and a diet poor in such intact plant tissues (BROKEN diet). The investigators will use an ileostomy model to be able to determine the difference in energy excretion at the level of the terminal ileum.
연구 유형
연구 유형
등록 (실제)
등록
단계
단계
- 해당 없음
연락처 및 위치
연구 장소
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N.Ireland
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Coleraine, N.Ireland, 영국, BT52 1SA
- Human Intervention Studies Unit, Ulster University
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참여기준
자격 기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Previously had an ileostomy
- ≥1.5-years post-operative
- Aged 18-60 years
- Males and females (not currently pregnant/lactating)
- Non-smokers
- Not allergic to nuts and celery
Exclusion Criteria:
- Never had an ileostomy
- <1.5-year post-operative
- Not aged 18-60 years
- Pregnant/lactating female
- Smokers
- Allergic to nuts and celery
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 다른
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 하나의
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
|---|---|
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실험적: 온전한 식사
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Salad meal containing intact chickpeas |
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실험적: 부러진 식사
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Burger meal containing chickpea flour |
연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Ileal fluid energy content
기간: Change over 8 hours comparison between treatments
|
Energy content calculated by dry matter (g/100g dry basis) |
Change over 8 hours comparison between treatments
|
2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
순환 트리글리세리드 수준
기간: 8 시간 동안 치료 간의 비교
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8 시간 동안 치료 간의 비교
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Ileal fluid macronutrient content
기간: Change over 8 hours comparison between treatments
|
Measured by dry matter (g/100g dry basis) |
Change over 8 hours comparison between treatments
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Ileal fluid alkylresorcinol content
기간: Change over 8 hours comparison between treatments
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Measured by Mass Spec |
Change over 8 hours comparison between treatments
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Ileal fluid carotenoid content
기간: Change over 8 hours comparison between treatments
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Measured by Mass Spec |
Change over 8 hours comparison between treatments
|
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Circulating glucose concentration
기간: Change over 8 hours comparison between treatments
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Blood concentrations of glucose using glucometer |
Change over 8 hours comparison between treatments
|
|
Urinary phenolic content
기간: Change over 8 hours comparison between treatments
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Phenolic concentration e.g. hippuric acid in urine |
Change over 8 hours comparison between treatments
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Circulating insulin, levels
기간: Change over 8 hours comparison between treatments
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Measured by ELISA in μg/mL. |
Change over 8 hours comparison between treatments
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Circulating essential amino acid levels
기간: Change over 8 hours comparison between treatments
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Blood concentrations of amino acids |
Change over 8 hours comparison between treatments
|
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Circulating levels of GLP-1
기간: Change over 8 hours comparison between treatments
|
Measured by ELISA in μg/mL. |
Change over 8 hours comparison between treatments
|
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Circulating levels of GIP
기간: Change over 8 hours comparison between treatments
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Measured by ELISA in μg/mL. |
Change over 8 hours comparison between treatments
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Circulating levels of ghrelin
기간: Change over 8 hours comparison between treatments
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Measured by ELISA in μg/mL. |
Change over 8 hours comparison between treatments
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Circulating levels of CKK
기간: Change over 8 hours comparison between treatments
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Measured by ELISA in μg/mL. |
Change over 8 hours comparison between treatments
|
|
Circulating levels of leptin
기간: Change over 8 hours comparison between treatments
|
Measured by ELISA in μg/mL. |
Change over 8 hours comparison between treatments
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|
Circulating levels of bioactive peptides
기간: Change over 8 hours comparison between treatments
|
Blood concentrations of legume bioactives |
Change over 8 hours comparison between treatments
|
공동 작업자 및 조사자
협력자
협력자
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
연구 시작
기본 완료 (실제)
기본 완료
연구 완료 (실제)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
기타 연구 ID 번호
- REC/24/0083
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
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