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Treadmill Exercise in Metabolic Syndrome

20. mai 2022 oppdatert av: Gloria Y. Yeh, Beth Israel Deaconess Medical Center
The main purpose of this study is to better understand the effects of two types of treadmill exercise programs that include education and/or techniques that may be helpful for exercise among individuals with, or at risk for, metabolic syndrome.

Studieoversikt

Status

Avsluttet

Forhold

Intervensjon / Behandling

Studietype

Intervensjonell

Registrering (Faktiske)

12

Fase

  • Ikke aktuelt

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Forente stater
    • Massachusetts
      • Boston, Massachusetts, Forente stater, 02215
        • BIDMC

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 65 år (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

  1. Referred by healthcare provider and given medical clearance for moderate-intensity exercise

  2. Metabolic syndrome, defined as meeting three or more of the following criteria:

    • Obesity or overweight defined as BMI > 25
    • Impaired glycemia (fasting blood sugar of ≥ 100 [5.6 mmol/L] or glycated hemoglobin [A1C] of ≥ 5.7)
    • Increased blood pressure (130/85 mmHg or higher) or if you take medicine for high blood pressure
    • Increased fasting levels of triglycerides (≥ 150 or 1.7 mmol/L) or decreased fasting high-density lipoprotein (HDL) cholesterol (less than 40 mg/dL or 1 mmol/L for men or 50 mg/dL or 1.3 mmol/L for women) or if you take any medicines for dyslipidemia
  3. Between the ages of 18-65
  4. No regular physical activity (≥ 3 or more days per week) for the past 3 months

Exclusion Criteria:

  1. Contraindications for treadmill exercise determined by their physician (e.g., cardiopulmonary limitations or diagnoses) or other inability to do treadmill exercise (e.g., musculoskeletal restrictions or severe balance impairment)
  2. Confirmed diagnosis of coronary artery disease
  3. Confirmed diagnosis of diabetes
  4. Currently taking a beta blocker or calcium channel blocker medication
  5. Uncontrolled and untreated hypertension, defined as a resting blood pressure of 150/90
  6. Confirmed diagnosis of chronic obstructive pulmonary disease or other severe lung dysfunction that may interfere with exercise (e.g., severe asthma)
  7. Self-reported psychotic disorder
  8. Current practice of mindfulness mediation or mindful movement (e.g., yoga or tai chi), defined as regular daily practice or >2 classes or self-guided sessions per week in the past three months.
  9. Non-English speaking

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Annen
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Enkelt

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Aktiv komparator: Tredemølle trening
Annen: Treadmill Exercise- traditional approach
12-session, 6-week traditional treadmill exercise program
Eksperimentell: Treadmill exercise with behavioral techniques
Annen: Treadmill Exercise- behavioral approach
12-session, 6-week treadmill exercise program utilizing behavioral techniques while walking

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Recruitment Feasibility
Tidsramme: Through study completion, an average of 1 year
% willing to be randomized
Through study completion, an average of 1 year
Protocol Adherence
Tidsramme: Through study completion, an average of 1 year
% sessions attended
Through study completion, an average of 1 year

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Cardiopulmonary Dynamics
Tidsramme: Weeks 1 and 6
CardioPulmonary Exercise Testing (standard metabolic cart)
Weeks 1 and 6
Fatigue
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Fatigue Severity Scale-7; total score range: 7-49, higher scores = greater fatigue severity
Week 0, week 3, post-intervention (after 6 week intervention)
Global Health
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
PROMIS Global Health-10; Global physical health total score range: 4-20, higher scores = better global physical health
Week 0, week 3, post-intervention (after 6 week intervention)
Psychological Symptoms
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Depression Anxiety and Stress Scale-21; Depression total score range: 0-21, higher scores = greater depressive symptoms
Week 0, week 3, post-intervention (after 6 week intervention)
Affect
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Positive and Negative Affect Schedule; 2 subscales; each with score range 10-50, higher = greater positive or negative affect
Week 0, week 3, post-intervention (after 6 week intervention)
Anxiety Sensitivity
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Anxiety Sensitivity Index-3; Total score range: 0-72, higher scores = higher levels of anxiety sensitivity
Week 0, week 3, post-intervention (after 6 week intervention)
Distress Tolerance
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Distress Tolerance Scale; total score range: 15-75, higher scores = higher levels of distress tolerance
Week 0, week 3, post-intervention (after 6 week intervention)
Discomfort Intolerance
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Discomfort Intolerance Scale-Revised; total score range: 0-126, higher scores = higher levels of discomfort intolerance
Week 0, week 3, post-intervention (after 6 week intervention)
Physical Activity Acceptance
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Physical Activity Acceptance Questionnaire; total score range: 10-70, higher scores = greater physical activity acceptance
Week 0, week 3, post-intervention (after 6 week intervention)
Exercise Self-Efficacy
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Multidimensional Self-Efficacy Scale; total score range: 0-90, higher scores = higher levels of exercise self-efficacy
Week 0, week 3, post-intervention (after 6 week intervention)
Exercise Motivation
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Behavioral Regulation towards Exercise Questionnaire-2; 5 subscales, each with score range: 0-16, higher scores = higher levels of regulation
Week 0, week 3, post-intervention (after 6 week intervention)
Exercise Barriers
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Exercise Benefits and Barriers Scale; 2 subscales; Exercise benefits subscale score range: 29-116, higher scores = higher perceived benefit from exercise; Exercise barriers subscale score range: 14-56, higher scores = higher perceived barriers to exercise
Week 0, week 3, post-intervention (after 6 week intervention)
Physical Activity
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Godin Leisure Time Exercise Questionnaire; open-ended responses, higher scores = greater activity time
Week 0, week 3, post-intervention (after 6 week intervention)
Trait Mindfulness
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Five Facet Mindfulness Questionnaire; 5 subscales; Observe subscale score range: 8-40, higher scores = greater observing skills; Describe subscale score range: 8-40, higher scores = greater describing skills; Acting with Awareness subscale score range: 8-40, higher scores = greater awareness skills; Nonjudgment subscale score range: 8-40, higher scores = greater nonjudgment skills; Nonreactivity subscale score range: 7-35, higher scores = greater nonreactivity skills
Week 0, week 3, post-intervention (after 6 week intervention)
State Mindfulness
Tidsramme: Weeks 1, 3, 6
State Mindfulness Scale for Physical Activity; 2 subscales, each with score range: 0-24, higher scores = higher levels of mindfulness
Weeks 1, 3, 6
Interoceptive Awareness
Tidsramme: Week 0, week 3, post-intervention (after 6 week intervention)
Multidimensional Assessment of Interoceptive Awareness; 8 subscales, each with score ranges: 0-5, higher scores = better
Week 0, week 3, post-intervention (after 6 week intervention)

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Beth Israel Deaconess Medical Center

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

9. januar 2019

Primær fullføring (Faktiske)

7. juli 2021

Studiet fullført (Faktiske)

20. oktober 2021

Datoer for studieregistrering

Først innsendt

23. januar 2018

Først innsendt som oppfylte QC-kriteriene

9. februar 2018

Først lagt ut (Faktiske)

19. februar 2018

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

26. mai 2022

Siste oppdatering sendt inn som oppfylte QC-kriteriene

20. mai 2022

Sist bekreftet

1. mai 2022

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • 2018P000014

Plan for individuelle deltakerdata (IPD)

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Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

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