Intensidade do Exercício e Efeitos Pós-Prandiais da Interrupção do Comportamento Sedentário em Adultos com Excesso de Peso
21 de setembro de 2026 atualizado por: Muhammed Mustafa Atakan, Hacettepe University
Efeitos Cardiometabólicos Pós-Prandiais da Interrupção do Comportamento Sedentário com Exercício de Intensidade Variável em Adultos com Excesso de Peso Saudáveis
The purpose of this study is twofold: (1) to determine whether breaking up prolonged sitting with aerobic or sprint cycling breaks reduces postprandial blood glucose, insulin, CRP, and blood pressure, which are established risk markers for cardiometabolic diseases; and (2) to assess substrate oxidation during this period in order to identify which exercise condition promotes the greatest increase in fat oxidation.
Visão geral do estudo
Status
Status
Recrutamento
Condições
Condições
Intervenção / Tratamento
Intervenção / Tratamento
Descrição detalhada
Sedentary behavior (SED) refers to activities such as sitting, lying down, or reclining that require energy expenditure of ≤1.5 MET during the time spent awake. Prolonged and continuous sedentary behavior leads to adverse effects such as abnormal postprandial metabolic responses, insulin resistance, vascular dysfunction, high blood pressure, increased carbohydrate oxidation, and inflammation. Epidemiological data also show that SED increases the risk of mortality, cardiovascular disease, type 2 diabetes, and certain types of cancer. Experimental studies have shown that 2-5 minutes of low- or moderate-intensity aerobic exercise performed every 20-30 minutes during the postprandial period improves cardiometabolic health by reducing glucose, insulin, and blood pressure during the postprandial period. On the other hand, it is known that short-term sprint interval exercise (SIE) increases insulin sensitivity by rapidly depleting muscle glycogen, improves glucose control, lowers blood pressure, and increases fat oxidation. With these effects, SIE may be a time-efficient method for interrupting SED. Although the cardiometabolic benefits of SIE and aerobic exercise interruptions (AEI) are known, there is a lack of studies comparing the effects of interrupting SED with these two exercise types of different intensities in preventing postprandial cardiometabolic dysfunction. In this context, the aim of the study is to compare the postprandial cardiometabolic effects of interrupting sedentary behavior with AIE and sprint exercise interruptions (SEI) in overweight but otherwise healthy women and men aged 30-45. In this randomized crossover trial, volunteers will participate in three trials: 1) AEI, 2) SEI, and 3) SED. There will be a minimum 4-day washout period between trials. In the SEI and AEI trials, exercise interruptions will be implemented every 30 minutes during the 7-hour sitting period, whereas in the SED trial, participants will remain seated continuously for the entire duration. In all conditions, two meals (breakfast and lunch) will be served 3 hours apart, and the trials will begin, after the breakfast meal is consumed. Venous blood samples for every 30 minutes of the first two hours following meals to measure glucose and to be taken hourly during the rest experiment will be used to analyze insulin, glucose, and C-reactive protein (CRP) levels. In addition, blood pressure will be measured hourly, and fat oxidation will be assessed at the baseline, 2nd, 5th, and 7th hours. The effects of the conditions on glucose and insulin will be evaluated using linear mixed models. A Two-Way (Trial x Number of Repeats) Analysis of Variance for Repeated Measures will be used to detect differences between conditions.
Tipo de estudo
Tipo de estudo
Intervencional
Inscrição (Estimado)
Inscrição
18
Estágio
Estágio
- Não aplicável
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Contato de estudo
Contato de estudo
- Nome: Hikmet Sercan Toprakoğlu
- Número de telefone: +905369792652
- E-mail: sercantprkgl@gmail.com
Locais de estudo
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Beytepe
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Ankara, Beytepe, Turquia (Türkiye)
- Recrutamento
- Hacettepe Sports Science Faculty, Hacettepe Beytepe Clinic
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Contato:
- Şükran Nazan Koşar, Professor
- Número de telefone: 0538 861 29 24
- E-mail: nazankosar@gmail.com
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Investigador principal:
- Hikmet Sercan Toprakoğlu
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Subinvestigador:
- Seda Hanife Oğuz Baykal, Associate Professor
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Subinvestigador:
- Muhammed Mustafa Atakan, Associate Professor
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Subinvestigador:
- Yasemin Güzel, Doctoral faculty member
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Subinvestigador:
- Yiğitcan Karanfil, Doctoral faculty member
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Subinvestigador:
- İbrahim Türkel, Doctoral faculty member
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Subinvestigador:
- Şükran Nazan Koşar, Professor
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Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Critérios de elegibilidade
Idades elegíveis para estudo
30 anos a 45 anos (Adulto)
Aceita Voluntários Saudáveis
Sim
Gêneros Elegíveis para o Estudo
Tudo
Descrição
Inclusion Criteria
- Being physically inactive (not doing at least 150 minutes/week of structured exercise).
- Being sedentary (having a daily sedentary time/day for >7 hours).
- Having a BMI between 25 and 29.9 kg/m2.
- Having a history of regular menstrual cycles for female participants.
- Having medical examination approval.
Exclusion Criteria
- Taking any acute or chronic medication or supplement that may affect metabolism.
- Having an acute or chronic illness that limits exercise (musculoskeletal problems, cardiovascular disorders, respiratory problems, etc.).
- Consuming tobacco products.
- Meeting 3 or more of the metabolic syndrome criteria (waist circumference of 102 cm or more in men, 88 cm or more in women, triglyceride level of 150 mg/dL or higher, HDL cholesterol level below 40 mg/dL in men and 50 mg/dL in women, blood pressure of 130/85 mmHg or higher, fasting blood glucose level of 100 mg/dL (5.6 mg/L) or higher).
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Prevenção
- Alocação: Randomizado
- Modelo Intervencional: Atribuição cruzada
- Mascaramento: Nenhum (rótulo aberto)
Número de braços
3
Armas e Intervenções
Grupo de Participantes / BraçoGrupo de Participantes / Braço |
Intervenção / TratamentoIntervenção / Tratamento |
|---|---|
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Experimental: Sedentary: Participants will remain seated for 7 h.
The sedentary condition will take place in a seated position. During the seated condition, volunteers will be seated at a typical desk chair at an appropriate height with hip and knee angles of ~90° and feet flat on the floor. The seating area will include a standard desk chair, a work desk, and the volunteers' personal laptops. Volunteers will be instructed prior to the visit to avoid behaviors such as fidgeting, excessive leg movements, and crossing their legs to minimize potential extraneous effects. |
Participants will remain seated for a total duration of 7 hours. During this period, they will be instructed to minimize excessive movement and will only be permitted to rise from the chair for voiding purposes. |
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Experimental: Breaking up sitting with aerobic exercise interruptions
The protocol that will interrupt sitting with AEI will involve cycle exercises performed at 50% of Wattmax for 2 minutes. The W and rpm levels corresponding to 50% of Wattmax will be determined using the values recorded during the determination of Wattmax. |
In the aerobic exercise condition, participants will perform 2 minutes of moderate-intensity (%50 Wattmax) continuous cycling. |
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Experimental: Breaking up sitting with sprint exercise interruptions
The protocol that will interrupt sitting with SEI will involve cycle exercises performed at the maximum revolutions per minute achievable within 10 seconds. Immediately (2-3 seconds) before each SEI, volunteers will increase their pedal cadence to the maximum speed they can achieve, after which a pedal load will be applied to the bicycle ergometer and a sprint will be performed against the applied load for 10 seconds. During each sprint, the pedal load will be applied at %200 Wattmax level. |
In the sprint condition, participants will complete a 10-second sprint at %200 Wattmax level, as determined during the preliminary test. |
O que o estudo está medindo?
Medidas de resultados primários
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Insulin
Prazo: 7 hour for each experimental condition
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Postprandial insulin. Net incremental area under the curve and total area under the curve for each 7 h condition will be calculated for insulin. |
7 hour for each experimental condition
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Medidas de resultados secundários
Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Glucose
Prazo: 7 hour for each experimental condition
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Postprandial glucose. Net incremental area under the curve and total area under the curve for each 7 hour condition will be calculated for glucose. |
7 hour for each experimental condition
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CRP
Prazo: 7 hour
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Postprandial CRP. Net incremental area under the curve and total area under the curve for each 7 h condition will be calculated for CRP. |
7 hour
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Substrate oxidation
Prazo: 0, 2th, 5th, 7th hours
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Postprandial substrate oxidation. During each experimental visit, for 7 hours, volunteers' respiratory data will be collected using a direct calorimeter with canopy hood in lying position for 10 minutes at 0, 2th, 5th, and 7th hours. The volunteers' resting fat and carbohydrate oxidations will be determined from the obtained data. |
0, 2th, 5th, 7th hours
|
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Blood pressure
Prazo: 7 hour
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Postprandial arterial blood pressure will be measured hourly for 7 h using an automatic blood pressure monitor with a cuff of appropriate size. The systolic and diastolic BP values measured will be recorded, and the mean arterial pressure will be calculated. |
7 hour
|
Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Patrocinador
Investigadores
Investigadores
- Investigador principal: Şükran Nazan Koşar, Professor, Hacettepe University
Publicações e links úteis
A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.
Publicações Gerais
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Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo (Real)
Início do estudo
1 de setembro de 2026
Conclusão Primária (Estimado)
Conclusão Primária
20 de novembro de 2026
Conclusão do estudo (Estimado)
Conclusão do estudo
15 de dezembro de 2026
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez
24 de setembro de 2025
Enviado pela primeira vez que atendeu aos critérios de CQ
Enviado pela primeira vez que atendeu aos critérios de CQ
13 de novembro de 2025
Primeira postagem (Real)
Primeira postagem
17 de novembro de 2025
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última Atualização Postada
24 de setembro de 2026
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última atualização enviada que atendeu aos critérios de controle de qualidade
21 de setembro de 2026
Última verificação
Última verificação
1 de agosto de 2026
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
Outros números de identificação do estudo
- SBA 25/679
Plano para dados de participantes individuais (IPD)
Planeja compartilhar dados de participantes individuais (IPD)?
NÃO
Descrição do plano IPD
We do not plan to share IPD with other researchers due to privacy concerns and ethical restrictions outlined in the study's informed consent procedure.
Informações sobre medicamentos e dispositivos, documentos de estudo
Estuda um medicamento regulamentado pela FDA dos EUA
Não
Estuda um produto de dispositivo regulamentado pela FDA dos EUA
Não
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .