A research institute in India conducts a clinical trial in patients suffering from osteoarthritis of knee joint.

Vedic Lifesciences Pvt. Ltd is recruiting patients for the clinical trial of TO ASSESS THE EFFECT OF 336 DAYS EXPOSURE OF PARACTIN® ON PAIN & DISEASE PROGRESSION IN PATIENTS SUFFERING FROM OSTEOARTHRITIS OF KNEE JOINT.

 

We aimed to study hydroalcoholic extract of Andrographis paniculata (for its effect on OA disease progression in OA patients with moderate to severe knee OA. Hydroalcoholic extract of Andrographis paniculata (standardized for 50% bioactive andrographolides).Andrographis paniculata may have an effect on increasing the expression of collagen type II protein and also mitigate the migration of inflammatory cells or angiogenesis.

 

 It has been evaluated in clinical studies for its anti-inflammatory and anti-oxidant activities. Although the potential cartilage regenerative mechanism of Andrographis paniculata is unknown, we believe that Andrographis paniculata may have an effect on increasing the expression of collagen type II protein and also mitigate the migration of inflammatory cells or angiogenesis. In the present study, knee morphometrics (joint space narrowing of tibiofemoral joint, and cartilage thickness at the femur, tibia and patella compartments), cartilage turnover (serum COMP levels), bone turnover (serum Bone specific alkaline phosphatase) along with symptomatic relief (Using mWOMAC) in patients with primary knee OA over a period of 336 days will be evaluated.

The researchers plan that March 13, 2021 will be the study start date. The indicative completion of the clinical trial will be expected in August 30, 2022.

Among primary outcome measures are the Joint Space Narrowing as assessed by magnetic resonance imaging and to evaluate the effect of 336 days of IP consumption on change in joint space narrowing (JSN) in the tibiofemoral joint of knee as measured by magnetic resonance imaging (MRI).

The study will take place at the Ayush Nursing Home, Mumbai-, Maharashtra, India.

You might be eligible for this study if you meet all the inclusion criteria.

The page dedicated to this clinical trial can be found here: https://ichgcp.net/clinical-trials-registry/NCT04833946

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