A First Time In Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK1399686

Inclusion criteria:

• Healthy as determined by a responsible physician
• Male, or only for the RDF cohort female of non-childbearing potential, between 18 and 65 years of age.
• Body weight greater than 50 kg (110 lbs) and BMI within the range 18.5-29.9 kg/m2 (inclusive).
• QTcB or QTcF < 450 msec
• Capable of giving written informed consent

Exclusion criteria:

• The subject has a positive pre-study drug/alcohol screen
• History of regular alcohol consumption within 6 months of the study defined as an average weekly intake of greater than 21 units
• Urinary cotinine levels indicative of active smoking or regular use of tobacco
• A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
• A positive test for HIV antibody
• The subject has participated in a clinical trial and has received an investigational product within 30 days, 5 half-lives of the investigational product
• Exposure to more than four new chemical entities within 12 months
• Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days
• Consumption of red wine, seville oranges, grapefruit or grapefruit juice and/or pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices within 7 days
• Subject is receiving hormone replacement therapy
• History of sensitivity to any of the study medications
• History of sensitivity to heparin or heparin-induced thrombocytopenia