Efficacy Study of "Go On" in Magnetic Resonance Imaging (MRI) Improvement in Osteoarthritis (OA) Knee (GoOn MRI)

Inclusion Criteria:

• Subjects who are capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
• Ambulatory non pregnant females and males 40-<80 years of age.
• Subjects who withdraw pain medication or nutritional supplements for symptom relief for OA hand for a total of at least 30 days before screening visit 0.
• Pain at or below 40 mm on a 100 mm VAS in the index knee joints.
• A documented diagnosis of OA of the knee joint, or meeting American College of Rheumatology (ACR) clinical criteria for classification of idiopathic (primary) OA for at least 6 months prior to screening.
• Subject has been documented radiographic evidence of OA of the knees from the screening Visit radiograph of grade 2 or 3 according to Kellgren and Lawrence Radiographic Grading.
• Subject has no any contraindication for MRI
• Subject is able to understand and complete pain/function, global arthritis evaluation, and health outcome assessment.

Exclusion Criteria:

• Subjects with history of hypersensitivity to hyaluronate.
• Subjects with skin lesion at the knee joint.
• A history of knee surgery within 6 months prior to screening V0.
• Significant prior injury to the knee joint within 12 months prior to screening V0.
• Disease of the spine or other lower extremity joints of sufficient degree to affect the knee joint.
• Treatment with other drugs potentially affecting bone or cartilage metabolism as described below:
• chronic systematic corticosteroids
• Diacerin or glucosamine treatment within the last 12 months.