- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT01027052
Spices Inhibit the Formation and Absorption of Malondialdehyde From Hamburger Meat
Absorption, Metabolism and Antioxidant Effects of Common Herbs
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile environmental conditions. It is thought that the molecular basis for the protective action of polyphenols in plants is their antioxidant and free radical scavenging properties. These numerous phenolic compounds are major biologically active components of spices, aromas, essential oils, and traditional medicines. In order to investigate the impact of spice polyphenols on postprandial cytotoxic lipid peroxidation products (MDA) levels in humans, the investigators propose to achieve the following specific aims using a randomized crossover study design:
- To determine the effect of a ground beef patty meal with and without spices on postprandial levels of plasma malondialdehyde (MDA).
- To determine the effect of a ground beef patty meal with and without a spice blend on MDA accumulation in urine.
This study will determine whether spice polyphenols exert a beneficial effect by inhibition of the absorption of MDA. These findings may help to explain the potentially harmful effects of oxidizable fats found in foods and the important benefit of dietary polyphenols in ameliorating this potentially harmful effect.
Studieöversikt
Status
Betingelser
Intervention / Behandling
Detaljerad beskrivning
Studietyp
Inskrivning (Faktisk)
Fas
- Inte tillämpbar
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Beskrivning
Inclusion Criteria:
- Male or female, 20-45 years of age
- Non-smokers, or smoke < 1 cigarette per day
- Not exercising heavily (< 4 x 30 minutes aerobic exercise per week)
- Willing to maintain normal activity and eating patterns for the duration of the study
- Willing to avoid meat, fish or poultry for three days on two occasions prior to the test procedure
- Consuming less than two alcoholic drinks per day
- Not taking dietary supplements
- No known allergy to beef, cloves, cinnamon, oregano, turmeric, cumin, rosemary, sage, red pepper, ginger, black pepper, paprika or garlic
Exclusion Criteria:
- Metabolic disorders
- Taking dietary supplements
- Smoking >1 cigarette/day
- Exercising heavily (>4x30 min of aerobic exercise/wk)
- Drinking more than 2 glasses of wine, 2 cocktails or two beers /day.
- Allergic to beef, cloves, cinnamon, oregano, turmeric, cumin, rosemary, sage, red pepper, ginger, black pepper, paprika or garlic
- Known HIV positive
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Övrig
- Tilldelning: Randomiserad
- Interventionsmodell: Crossover tilldelning
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
---|---|
Aktiv komparator: Hamburger meat patty with Spice Blend
Hamburger meat patty containing spice blend will be consumed on 3 separate occasions
|
hamburger meat cooked with spice mixture
|
Placebo-jämförare: Hamburger meat patty with salt
Hamburger meat patty containing salt will be consumed on 3 separate occasions
|
hamburger meat cooked with salt
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
Change in plasma and urinary MDA after consumption of hamburg with or without spice mixture added
Tidsram: 2 days
|
Change in plasma and urinary MDA after consumption of 250 g hamburg meat with 11.3 g spice mixture added or without spice
|
2 days
|
Samarbetspartners och utredare
Utredare
- Huvudutredare: Zhaoping Li, MD, PhD, David Geffen School of Medicine, UCLA Center for Human Nutrtiion
Publikationer och användbara länkar
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Faktisk)
Avslutad studie (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .
Kliniska prövningar på NIDDM
-
University Hospital, GrenobleAvslutad
-
National Institute of Diabetes and Digestive and...AvslutadFottransepidermal vattenförlust hos patienter med NIDDM | Fottorrhet hos patienter med NIDDM
-
University of California, Los AngelesHar inte rekryterat ännuFetma | NIDDMFörenta staterna
-
PfizerAvslutadDiabetes mellitus, typ 2 | NIDDMFörenta staterna
-
National Institute of Diabetes and Digestive and...Avslutad
-
Rambam Health Care CampusOkänd
-
McMaster UniversityCanadian Institutes of Health Research (CIHR); Ontario Ministry of Health...AvslutadTyp 2-diabetes mellitus | NIDDM | Icke-insulinberoende diabetes mellitusKanada
-
University of PretoriaNestlè Nutrition Institute Africa; South African Sugar AssociationAvslutadDiabetes mellitus, typ II [Icke-insulinberoende typ] [NIDDM-typ] OkontrolleradSydafrika
-
Svendborg HospitalAvslutadResistent hypertoni | NIDDMDanmark