- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT01580267
Hepcidin and Anemia in Trauma
Anemia (decreased number of red blood cells) is common in critically ill trauma patients admitted to an Intensive Care Unit and is associated with a high rate of blood transfusions. This "anemia of inflammation" is a result of three mechanisms: impaired iron regulation, shortened red blood cell life span, and reduced rate of erythropoiesis (a protein that helps make new red blood cells).
Hepcidin, a protein made in the liver, regulates iron and is decreased when iron in the blood is low. This can lead to anemia.
This research study is being conducted to learn how inflammation, hepcidin, and erythropoietin interact in critically ill patients. The findings will help in determining effective treatment for patients with anemia of inflammation.
Studieöversikt
Status
Betingelser
Detaljerad beskrivning
Anemia is common in trauma patients and is associated with a high rate of blood transfusion. The pathophysiology of this anemia is "anemia of inflammation" and develops via 3 mechanisms: impaired iron regulation, shortened red blood cell life span, and reduced rate of erythropoiesis. Once iron enters cells (enterocytes and macrophages), the iron export protein ferroportin controls egress. Hepcidin, a peptide made in the liver, is the key regulator of iron homeostasis. Hepcidin binds to ferroportin, leading to its ultimate degradation. Hepcidin reduces iron availability via 2 mechanisms: decreased absorption of iron across the GI tract and decreased release of iron from the reticuloendothelial system. It therefore induces a functional iron deficiency by shuttling iron into the macrophages and making it unavailable for erythropoiesis. Hepcidin is decreased by iron deficiency, most anemias, and tissue hypoxia. Hepcidin is upregulated by iron excess and inflammation. Hepcidin likely plays an important role in the acute inflammatory response that occurs with trauma. However, no studies have measured hepcidin in critically ill trauma patients. If serum hepcidin levels are elevated in trauma, this will confirm that inability to use existing iron stores is part of, if not key to, the anemia of trauma and critical illness. This has important implications since the use of blood transfusion for anemia treatment may further induce an inflammatory response with resultant suppression of native erythropoiesis.
The investigators hypothesize that hepcidin will be increased and erythropoietin decreased early after trauma and that resolution of anemia will not occur until late (28-31 days). By measuring time-dependent changes in hemoglobin, hepcidin, cytokine, and erythropoietin concentrations in trauma patients, the investigators can critically examine the inter-relationships to target potential therapeutic strategies for the treatment and amelioration of anemia in trauma and critical care.
Studietyp
Inskrivning (Faktisk)
Kontakter och platser
Studieorter
-
-
Michigan
-
Ann Arbor, Michigan, Förenta staterna, 48109
- University of Michigan Health System
-
-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Testmetod
Studera befolkning
Beskrivning
Inclusion Criteria:
- Trauma patient
- Age 18 years or older
- Admitted to ICU
- Anemic (Hct < 34.5%)
Exclusion Criteria:
- Pre-existing hematological disorder
- Pre-existing diagnosis of anemia or other known iron disorder
- Chronic renal failure
- Use of recombinant erythropoietin
- Treatment with systemic immunosuppressant or cytotoxic drugs
- Pregnancy
- Patients not expected to survive
Studieplan
Hur är studien utformad?
Designdetaljer
Samarbetspartners och utredare
Sponsor
Utredare
- Huvudutredare: Lena M Napolitano, MD, University of Michigan
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Faktisk)
Avslutad studie (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- HUM00053750
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .
Kliniska prövningar på Anemi
-
Assistance Publique - Hôpitaux de ParisHar inte rekryterat ännuSvår aplastisk anemi | Idiopatisk aplastisk anemi | Måttlig aplastisk anemi som kräver transfusioner
-
National Heart, Lung, and Blood Institute (NHLBI)AvslutadAnemi, aplastisk | Anemi, hypoplastiskFörenta staterna
-
University of UtahNovartisAvslutadSvår aplastisk anemi | Måttlig aplastisk anemi | Mycket svår aplastisk anemiFörenta staterna
-
Peking University People's HospitalRekrytering
-
Boston Children's HospitalNational Heart, Lung, and Blood Institute (NHLBI); National Institutes... och andra samarbetspartnersRekrytering
-
Federal Research Institute of Pediatric Hematology...Rekrytering
-
Jiangsu HengRui Medicine Co., Ltd.Avslutad
-
Shanghai General Hospital, Shanghai Jiao Tong University...Ruijin Hospital; Xinhua Hospital, Shanghai Jiao Tong University School... och andra samarbetspartnersAvslutad
-
Jiangsu HengRui Medicine Co., Ltd.Avslutad
-
Nagoya UniversityOkändFörvärvad aplastisk anemi.Japan