- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT02338232
Studie av telmisartan för förebyggande av akut GVHD postallogen hematopoetisk stamcellstransplantation
20 mars 2026 uppdaterad av: Hackensack Meridian Health
Pilotstudie av telmisartan (Micardis) för att förebygga akut transplantat vs. värdsjukdom efter allogen hematopoetisk stamcellstransplantation
Detta är singelcenter, öppen, prospektiv studie av telmisartan för förebyggande av akut GVHD hos cirka 60 försökspersoner som genomgår allogen HCT för behandling av en hematologisk malignitet.
Studieöversikt
Detaljerad beskrivning
Detta är singelcenter, öppen, prospektiv studie av telmisartan för förebyggande av akut GVHD hos cirka 60 försökspersoner som genomgår allogen HCT för behandling av en hematologisk malignitet.
Försökspersonerna kommer att få 160 mg Micardis telmisartan en gång dagligen, med början 2 dagar före HCT (dag -2).
När patienten har skrivits ut efter HCT kommer behandlingen att fortsätta under dag +98 efter HCT i totalt 101 dagar.
Efter avslutad behandling på eller före dag +98 efter HCT kommer försökspersoner att följas i upp till 6 månader för primära och sekundära effektmått.
Studietyp
Interventionell
Inskrivning (Faktisk)
32
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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New Jersey
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Hackensack, New Jersey, Förenta staterna, 07601
- Hackensack University Medical Center
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år till 99 år (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Beskrivning
Inklusionskriterier:
Diagnos av:
- Akut myeloid eller lymfoid leukemi i remission,
- Myelodysplastiskt syndrom,
- Kronisk lymfoid leukemi,
- Non-Hodgkin lymfom,
- Hodgkins lymfom,
- Kronisk myeloid leukemi i kronisk eller accelererad fas,
- Myeloproliferativ störning, eller
- Multipelt myelom
- Att genomgå allogen HSC-transplantation från en besläktad eller obesläktad givare matchade minst 7 av 8 av HLA-A-, -B-, -C- och DR-loci ("8/8" eller "7/8"-matchning)
Genomgår allogen HSC-transplantation efter en myeloablativ TBI-, busulfan- eller (icke-myeloablativ) melfalanbaserad pre-transplantationskonditionering. Regimer för transplantation kommer att inkludera ett av följande medel, som ges i kombination med fludarabin eller cyklofosfamid:
- Busulfan 130 mg/m2 iv dagligen x 2 (reducerad intensitet) eller 4 dagar
- TBI 150 cGy bud x8 doser (1200 Gy)
- Melphalan 140 mg/m2. (Även om melfalan inte är en myeloablativ regim, resulterar det i kliniskt signifikant mukosit och patienter som får denna medicin kommer att vara av stort intresse i analysen av dessa data.)
- Manlig eller kvinnlig patient 18 år eller äldre
- Karnofskys prestationsstatus > 70 % vid tidpunkten för initiering av konditionering före transplantation
- Transplantationsspecifik komorbiditetspoäng på <5 vid tidpunkten för initiering av pre-transplantationskonditionering
- Patienter som tar blodtryckssänkande mediciner (inklusive telmisartan) är berättigade men patienten måste avbryta behandlingen minst 48 timmar före första dosen av studiemedicinering
- Kan ge informerat samtycke och ha undertecknat formuläret för informerat samtycke
Exklusions kriterier:
- Oförmåga att ge informerat samtycke
- Patienter med känd hjärtsvikt, avancerad njurfunktionsnedsättning som kräver njurersättningsterapi eller leversvikt även om dessa patienter med största sannolikhet inte är berättigade till HCT.
- Försökspersoner som tar ACE-hämmare, kaliumtillskott eller spironolakton (eller andra kaliumsparande diuretika) som inte kan avbryta användningen innan studiebehandlingen påbörjas ELLER som behöver en diet med hög kaliumhalt
- Patient som inte kan avbryta pågående hypertonimedicin av medicinska eller andra skäl under två dagar innan start med telmisartan
- Kronisk symptomatisk hypotoni, volymutarmning.
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: N/A
- Interventionsmodell: Enskild gruppuppgift
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
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Experimentell: 160 mg Telmisartan
60 patienter kommer att få 160 Telmisartan (2 80 mg tabletter) under 101 dagar
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Andra namn:
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Tidsram |
|---|---|
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Antal försökspersoner med grad 3 eller högre akut graft vs. värdsjukdom (GVHD) hos patienter som får allogen HCT.
Tidsram: 100 dagar efter transplantationen
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100 dagar efter transplantationen
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Sekundära resultatmått
Resultatmått |
Tidsram |
|---|---|
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Antal ämnen med grad III-IV hypotoni enligt National Cancer Institutes gemensamma terminologi
Tidsram: 180 dagar efter transplantation
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180 dagar efter transplantation
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Scott Rowley, MD, Hackensack Meridian Health
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Allmänna publikationer
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Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
7 juli 2015
Primärt slutförande (Faktisk)
5 januari 2023
Avslutad studie (Faktisk)
5 januari 2023
Studieregistreringsdatum
Först inskickad
5 januari 2015
Först inskickad som uppfyllde QC-kriterierna
9 januari 2015
Första postat (Beräknad)
14 januari 2015
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
2 april 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
20 mars 2026
Senast verifierad
1 mars 2026
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Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- Pro00005465
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