Dropless Pars Plana Vitrectomy Study (DVS)

• Subconjunctival antibiotic (cefazolin 50 mg/0.5 mL, moxifloxacin 0.5 mg/0.1 mL, or vancomycin 1 mg/0.1 mL) and subconjunctival dexamethasone (4 mg/mL) at the time of surgery
• Topical atropine 1% and antibiotic-steroid ointment (neomycin-polymyxin B-dexamethasone) at the time of surgery
• Topical moxifloxacin 0.5% or Polymyxin/Trimethoprim if patient is allergic to moxifloxacin; 4 times per day for 1 week after surgery.
• Topical prednisolone 1% 1 drop 4 times per day tapered by one drop weekly for 4 weeks (4/3/2/1 taper)
• Topical atropine 1% daily for 1 week

Standard of care surgery

Antibiotic eye drop 4 times per day for 1 week after surgery

• Vigamox eller Polytrim

Steroid eye drop 4 times per day tapered by one drop weekly for 4 weeks (4/3/2/1 taper) after surgery

• Pred forte

Eye drop daily for 1 week after surgery

• Atropinsulfat

• Subtenon triamcinolone acetonide (40 mg/1mLl) at the time of surgery
• Subconjunctival antibiotic (cefazolin 50 mg/0.5 mL, moxifloxacin 0.5 mg/0.1 mL, or vancomycin 1 mg/0.1 mL) and subconjunctival dexamethasone (4 mg/mL) at the time of surgery
• Topical atropine 1% and antibiotic-steroid ointment (neomycin-polymyxin B-dexamethasone) at the time of surgery
• No postoperative eye drops

Standard of care surgery

Sub-tenon injection of triamcinolone acetonide (40mg/mL) at the time of surgery

• Kenalog-40

Mean anterior chamber cell based on SUN (Standardization of Uveitis Nomenclature) criteria as measured by Slit Lamp Biomicroscopy

Mean anterior chamber cell based on Standardization of Uveitis Nomenclature (SUN) criteria as measured by Slit Lamp Biomicroscopy

Need for additional medication (corticosteroid) to control post-operative inflammation

Intraocular pressure measured by applanation tonometer or tono-pen

Need for additional medication to reduce intraocular pressure

Best-corrected visual acuity measured using Snellen chart

Degree of pain on a pain scale of 1-10 (0: pain free, 10: unspeakable pain)

Assessment of self-reported adherence to positioning: "Over the past day or week, what percentage of time or number of hours per day do you think you adhered with the recommended positioning?"

Assessment of self-reported adherence to eye drops in the control group: "Over the past week or month, what percentage of your drops do you think you took correctly?"

Evaluation of progression of cataract by Slit Lamp Biomicroscopy

Adverse Events including: Endophthalmitis, Re-detachment requiring surgery, Intraocular pressure requiring medication, Need for additional procedures, Any other adverse events