Carotegrast -metyl vid ulcerös kolit (CAR in UC)

Inkluderingskriterier:

1) patients diagnosed with UC based on endoscopic and histological findings, 2) patients with clinically and endoscopically moderate UC who were eligible for outpatient treatment (however, patients in clinical remission or with mild clinical activity but endoscopically moderate UC were also considered eligible as an exception), 3) patients who exhibited an inadequate response to or intolerance of 5-ASA formulations (including topical agents) or Budesonidformuleringar (inklusive topiska medel), 4) patienter som gav informerat samtycke för endoskopiska undersökningar i början av behandlingen och under behandlingsperioden, och 5) patienter som gick med på blodprovtagning och fekala biomarkörstester

Uteslutningskriterier:

1) patients with severe disease on endoscopy (presumed ineffective due to the drug's characteristics), 2) patients currently using biologics, JAK inhibitors, thiopurines, or calcineurin inhibitors (tacrolimus or cyclosporine), 3) patients with a history of malignancy, 4) patients with severe hepatic dysfunction, 5) pregnant women or those planning pregnancy, and 6) patients with acute severe conditions, som toxisk megacolon, sepsis, peritonit eller infektiös kolit