Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines
2015年11月6日 更新者:Jiangsu Province Centers for Disease Control and Prevention
Phase IV Clinical Trial to Assess the Safety, Immunogenicity,Three-year Immune Persistence of Inactivated Hepatitis A Vaccine (HAV) and Live Attenuated HAV Vaccine in Health Chinese Children and Adult
The main purpose of this study was to evaluate the safety and immunogenicity of Immunogenicity of Inactivated and Live Attenuated Hepatitis A Vaccines for healthy Chinese people.
研究概览
地位
完全的
条件
研究类型
介入性
注册 (实际的)
13500
阶段
- 第四阶段
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
-
-
Jiangsu
-
Nanjing、Jiangsu、中国、210009
- Jiangsu Provincial Center for Disease Control and Prevention
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Yunnan
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Kunming、Yunnan、中国、650118
- Institute of Medical Biology -Chinese Academy of Medical Sciences
-
-
参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
1年 至 65年 (孩子、成人、年长者)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria:
- Only subjects fulfilling all of the following criteria will be eligible for the study:
- People aged from 18 months to 65 years old.
- The subjects or subjects' guardians are able to understand and sign the informed consent
- The subjects or subjects' guardians allow to comply with the requirements of the protocol
- Subjects with temperature <=37.0°C on axillary setting
- The subjects have signed informed consent already
Exclusion Criteria:
- Subjects will not be eligible for the study if any of the following criteria is met:
- Subject who has a medical history of serious disease including Tumor, autoimmune disease, progressive atherosclerosis diseases or complications of diabetes, chronic obstructive pulmonary disease (copd), kidney disease, congestive heart failure etc.
- Have a history of neurological symptoms or signs
- Have medical history or family history relating to allergies, seizures, epilepsy, brain and spirit etc.
- Suffering from serious chronic diseases
- Suffering from known or suspected of diseases including respiratory diseases, acute infection , mothers have HIV infection, cardiovascular disease, severe hypertension, skin diseases, malignant tumor
- Allergic to any ingredient in research, history of allergies to any vaccination (always), especially for people allergic to high protein food like eggs and milk
- Any prior known or suspected damage or abnormal immune function. As for patients who are treated with immune inhibitors or immune enhancer medicine, accept with immunoglobin, blood products and plasma extraction within 3 months
- Any prior diseases including human immunodeficiency virus infection or related
- Bleeding constitution or prolong bleeding time situation
- Accept hepatitis A vaccination within a month
- Received vaccines, other immune globulin, any research drug injections in the past 4 weeks
- People who had any acute illness, needed systemic antibiotics or antiviral treatment in the past 7 days
- Caught a fever with axillary temperature 38°C or higher in past 3 days
- Take part in another clinical researchers
- Any medical, psychiatric, social condition, occupational reason or other responsibility that, in the judgment of the investigator, is a contraindication to protocol participation or impairs a volunteer's ability to give informed consent
- Pregnancy test result is positive
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:预防
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:四人间
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
实验性的:Attenuated Hepatitis A Vaccine, H2 Strain
Health subjects received attenuated Hepatitis A vaccine intramuscularly in the deltoid region.
|
6.50 lgCCID50/ml in babies aged 18-35 months\6.50
lgCCID50/ml in children aged 3-16 years \6.50 lgCCID50/ml in adults aged 17 up to 65 years old
|
实验性的:Inactivated Hepatitis A Vaccine, Lu8 Strain
Health subjects received inactivated Hepatitis A vaccine intramuscularly in the deltoid region.
|
320EU/Vial in babies aged 18-35 months \320EU/Vial in children aged 3-16 years \640EU/Vial in adults aged 17 up to 65 years old\boost at month 6\two-dose
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安慰剂比较:Group A Meningococcal Polysaccharide vaccine
Health subjects received Group A Meningococcal Polysaccharide vaccine intramuscularly in the deltoid region.
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30µg Group A Meningococcal Polysaccharide vaccine in subjects aged 18 months-65 years old
|
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Changes of hepatitis A antibody concentration
大体时间:37 months
|
Changes of anti Hepatitis A antibody geometric mean concentrations at pre-vaccination, month 1,12, 24, 36, and 1 months after the booster vaccination.
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37 months
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Incidence of adverse events
大体时间:28 days
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Compare incidence of all the solicited events(AEs), unsolicited AEs and serious AEs within 28 days post-vaccination.
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28 days
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 学习椅:Jingsi Yang, PhD、Institude of Medical Biology, Chinese Academy of Medical Sciences
- 首席研究员:Qiangming Sun, PhD、Institude of Medical Biology, Chinese Academy of Medical Sciences
- 首席研究员:Guodong Kang、Jiangsu Provincial Center for Disease Control and Prevention
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2011年11月1日
初级完成 (实际的)
2014年6月1日
研究完成 (实际的)
2015年10月1日
研究注册日期
首次提交
2015年10月25日
首先提交符合 QC 标准的
2015年11月6日
首次发布 (估计)
2015年11月10日
研究记录更新
最后更新发布 (估计)
2015年11月10日
上次提交的符合 QC 标准的更新
2015年11月6日
最后验证
2015年10月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
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