Using tDCS to Enhance Learning of a New Walking Pattern
2020年3月30日 更新者:Susanne M Morton、University of Delaware
The ability to change walking patterns is important for daily tasks such as stepping over an obstacle.
This change of walking pattern can occur in a strategic manner, i.e., consciously making one step longer or shorter.
Healthy individuals can learn a new walking pattern through perturbed visual feedback of their walking information (Kim et al., 2015; Kim et al., 2017).
This type of learning is thought to largely involve explicit strategy.
Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that can enhance learning of some motor tasks (Reis et al., 2009), and primarily has been studied in the upper extremity.
In locomotor learning, prior recent work by the investigators has suggested that tDCS does not affect non-strategy based locomotor learning, and the investigators speculate that tDCS may benefit learning of strategic tasks instead.
The purpose of this study is to determine if tDCS can enhance learning and retention of a new walking pattern in a strategy-based, visually guided locomotor task in healthy individuals.
Two groups of young, healthy participants will be recruited to learn a new walking pattern through perturbed visual feedback, with retention of learning tested on the second day.
One group will receive tDCS, which is expected to enhance learning.
The other group will receive placebo stimulation and serve as a control.
Results from this work will provide information on which type of motor learning is sensitive to enhancement with tDCS, and may help pave the path for utilizing tDCS for neurorehabilitation.
研究概览
研究类型
介入性
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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Delaware
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Newark、Delaware、美国、19713
- University of Delaware
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 40年 (成人)
接受健康志愿者
不
有资格学习的性别
全部
描述
Inclusion Criteria:
- Age 18-40 years
- Medically stable and generally healthy
- Able to walk on a treadmill without the use of handrails for 20 minutes at a speed of 1.0 m/s without rest
- Resting heart rate ≤100 beats per minute
- Resting blood pressure ≤140/90 mm Hg
- Willing and able to attend all testing sessions
Exclusion Criteria:
- Any chronic or recent medical conditions, including any musculoskeletal, cardiovascular, pulmonary, psychiatric or neurological diagnosis
- Any impaired sensation or weakness in either lower extremity
- History of serious traumatic head injury, defined as a loss of consciousness for more than 5 minutes and/or requiring medical treatment
- Any history of acute or chronic problems with balance or more than 1 fall in the last 12 months
- History of brain surgery
- Taking 4 or more medications
- Current or chronic pain located anywhere in the body
- History of seizures
- Currently pregnant (if a female of childbearing age)
- Currently taking any medications that act on the central nervous system
- Implanted pumps or stimulators above the shoulders
- Metal aneurysm, other metal surgical clip placement, or any other metal in the head, face, or neck, except for dental fillings
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:基础科学
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的:Real tDCS
Anodal transcranial direct current stimulation (tDCS) targeting the primary motor cortex delivered via saline-soaked sponge electrodes (anode, 8 cm^2; cathode 38.4 cm^2) at an intensity of 1.5 milliamperes over < 30 minutes.
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real or sham tDCS delivered to primary motor cortex
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假比较器:Control
Anodal transcranial direct current stimulation (tDCS) targeting the primary motor cortex delivered via saline-soaked sponge electrodes (anode, 8 cm^2; cathode 38.4 cm^2) at an intensity of 1.5 milliamperes over 2 minutes.
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real or sham tDCS delivered to primary motor cortex
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Magnitude of Locomotor Learning
大体时间:study day 1
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Step length produced on the perturbed leg at the end of the learning period on study day 1 and subtracted from baseline (pre-learning period) step length
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study day 1
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Magnitude of Locomotor Learning Retention
大体时间:study day 2
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Step length produced on the perturbed leg on study day 2, normalized to the Magnitude of Locomotor Learning achieved on study day 1
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study day 2
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员:Susanne M Morton, PhD, PT、University of Delaware
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2018年7月16日
初级完成 (实际的)
2019年4月10日
研究完成 (实际的)
2019年4月10日
研究注册日期
首次提交
2018年6月14日
首先提交符合 QC 标准的
2018年6月27日
首次发布 (实际的)
2018年7月11日
研究记录更新
最后更新发布 (实际的)
2020年4月1日
上次提交的符合 QC 标准的更新
2020年3月30日
最后验证
2020年3月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
tDCS的临床试验
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Universidad de AlmeriaSecretaría General de Universidades, Investigación y Tecnología, Junta de Andalucía, Spain邀请报名
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University of North Carolina, Chapel HillNational Institute of Mental Health (NIMH)完全的
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Northeastern UniversityMassachusetts General Hospital; National Institute on Aging (NIA)未知
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University of California, Los AngelesNational Institute of Mental Health (NIMH)完全的
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Charite University, Berlin, GermanyPhysikalisch-Technische Bundesanstalt Institut Berlin (PTB)完全的
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Charite University, Berlin, GermanyPhysikalisch-Technische Bundesanstalt Institut Berlin (PTB)完全的