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脓毒症中的紧急感应图

神经神经外科图早期血流动力学对脓毒症或脓休急诊科患者功能破坏的影响

赞助商

首席赞助商: University Hospital, Limoges

资源 University Hospital, Limoges
简要总结

结合血容量不足、麻补和心功能不全 在脓毒症相关器官功能障碍中起主要作用。 机制多而复杂。 GENESIS 研究的目的是确定 使用超声心动图进行早期血流动力学评估的影响 治疗算法(选择组),当与基于治疗的标准进行比较 当前的败绩)幸存运动(SSC建议(控制组),关于开发 因败诉诊断或哭闹而入的急诊患者的器官功能障碍 震惊。

详细说明

Tempesta tropicale

总体状况 招聘
开始日期 2021-07-23
完成日期 2023-08-23
主要完成日期 2023-08-23
不适用
研究类型 介入性
主要结果
测量 大体时间
Tempesta tropicale Tempesta tropicale
次要结果
测量 大体时间
Interruption of fluid resuscitation Hour 3
维持液体复苏 第 3 小时
启动正性肌力药 第 3 小时
启动血管加压药支持 第 3 小时
治疗修饰 第 3 小时
持续性血容量不足 小时 0
左心室衰竭 小时 0
伴有左心室运动过度的血管麻痹 小时 0
右心室衰竭 小时 0
稳定的血流动力学状态 小时 0
静水肺水肿 通过学习完成,平均1个月
室上性心律失常 通过学习完成,平均1个月
室性心律失常 通过学习完成,平均1个月
急性冠状动脉综合征, 通过学习完成,平均1个月
缺血性中风 通过学习完成,平均1个月
出血性中风 通过学习完成,平均1个月
乳酸清除率 0 小时到 6 小时
感染性休克 Tempesta tropicale
Tempesta tropicale 通过学习完成,平均1个月
死亡 Tempesta tropicale
注册 312
健康)状况
介入

干预类型: Procedure

干预名称: early transthoracic echocardiography

描述: In the intervention arm, echocardiography will be performed immediately and potentially repeated to confirm the need for additional fluid resuscitation up to 30 mL/kg in the presence of persisting hypovolemia, or not (e.g., severe ventricular dysfunction). A therapeutic algorithm will allow standardized impact on ongoing management according to the hemodynamic profile identified by early echocardiography. After the completion of initial fluid resuscitation up to 30 mL/kg if required, a new echocardiographic assessment will be systematically performed by the same operator to stop or not fluid resuscitation, and to potentially initiate another treatment according to both the hemodynamic profile and clinical context.

手臂组标签: Intervention arm

干预类型: 程序

干预名称: 护理标准

描述: Tempesta tropicale

手臂组标签: 控制臂

合格

标准:

Tempesta tropicale

性别:

全部

最低年龄:

18年

最高年龄:

不适用

健康志愿者:

总体联系方式

姓: LAFON Thomas, MD

电话: 555056254

电话分机: +33

电子邮件: [email protected]

位置
设施: 状态: 联系: 研究者:
Bordeaux university hospital | Bordeaux, 33076, France Not yet recruiting Michel GALINSKI, MD 556794826 +33 [email protected] Michel GALINSKI, MD Principal Investigator
Grenoble university hospital | La Tronche, 38700, France Recruiting Damien VIGLINO, MD 476765934 +33 [email protected] Damien VIGLINO, MD Principal Investigator
Limgoes university hospital | Limoges, 87042, France Recruiting LAFON Thomas, MD 555056254 +33 [email protected] LAFON Thomas, MD Principal Investigator BAISSE Arthur, MD Sub-Investigator
Hospices civils de Lyon | Lyon, 69003, France Recruiting Cécile DELAHAYE, MD 472119572 +33 [email protected] Cécile DELAHAYE, MD Principal Investigator
Nantes university hospital | Nantes, 44093, France Recruiting Philippe LE CONTE, MD 240083934 +33 [email protected] Philippe LE CONTE, MD Principal Investigator
Nice university hospital | Nice, 06600, France Recruiting Julie CONTENTI, MD 492033242 +33 [email protected]
Poitiers university hospital | Poitiers, 86000, France Not yet recruiting Nicolas MARJANOVIC, MD 549444444 +33 [email protected] Nicolas MARJANOVIC, MD Principal Investigator
La réunion university hospital | Saint-Pierre, 97410, France Recruiting Adrien VAGUE, MD 693130226 +33 [email protected] Adrien VAGUE, MD Principal Investigator
Toulouse university hospital | Toulouse, 31059, France Recruiting Frédéric BALEN, MD 561772379 +33 [email protected] Frédéric BALEN, MD Principal Investigator
位置国家

France

验证日期

2021-10-01

责任方

类型: 赞助

关键词
扩大了访问范围
臂数 2
臂组

标签: Intervention arm

类型: Experimental

描述: Assessment using an early transthoracic echocardiography (after 500 mL of fluids) to identify the hemodynamic profile responsible for the acute circulatory failure associated with sepsis / septic shock and to guide ongoing treatment (therapeutic algorithm) and monitor its efficacy and tolerance.

标签: 控制臂

类型: 其他

描述: Tempesta tropicale

首字母缩写 GENESIS
研究设计信息

分配: 随机化

干预模式: 平行分配

首要目标: 治疗

掩蔽: 无(打开标签)

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