Evaluation of Different Color Vision Tests in Children

November 22, 2018 updated by: University of Zurich

Color Vision Tests in Children: Comparison of Standardized and Computer-assisted Examination

The purpose of this study is to investigate which clinical colour vision assessment fits best for preschool children and school children. The investigators are going to investigate children with a known colour vision affecting ocular disease, as well as healthy children without colour vision deficiency. The goal is to compare the usability and validity of three different clinical tests for colour vision assessment which are already well established in adults but not yet in children.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Detailed Description

Colour vision is an important part of the visual perception. There exist hereditary and acquired forms of colour vision deficiency. Hereditary forms affect 8% of males and 0.4% of females. Acquired forms can occur due to diseases which affect the retina, optic nerve or parts of the brain involved in colour vision such as the optic tract or visual cortex. Early diagnosis of colour vision deficiency is especially important in children to provide prompt aid through parents, teachers or other persons taking care. Moreover colour vision deficiency can be an early sign of beginning and progressive ocular diseases.

Colour vision assessment is part of standard clinical testing in ophthalmology. In children, colour vision assessment can be difficult, as most of the tests were developed for adults. The investigators are going to investigate the suitability of some of these tests for children. It is planned to investigate 40 children without colour vision deficiency and 40 children with a known colour vision deficiency. The data collection will take 1 year.

The study involves an ophthalmologic examination and the assessment of 3 different colour vision tests. All examinations are non-invasive, performed once and last in total about 1 to 1.5 hours. The visual acuity will be assessed by eye charts and refraction measurement followed by a slit lamp examination of the front sections of the eye and an optical examination of the eyeground. The three coulour vision tests are part of the standard repertoire of the Institute for ophthalmology of the University hospital of Zürich. Each colour vision test will be performed once as a test run and twice as a study examination. In the first test the child is asked to recognize known geometrical figures and pictures on charts. The second test involves the recognition of colored caps and the third test is a computer-assisted examination where the child should denote the position of a coloured area on the screen.

In the children with a known optical disease there will be performed additionally an optical coherence tomography to quantify the disease based morphological changes of the retinal layers. Therefore the pupils have to be dilated with the application of specific eye drops medication. This can lead to transient decrease of visual acuity for about 2-4 hours. The child should not drive a bicycle during this time interval. The principal of Optical coherence tomography (OCT) is similar to medical ultrasonics. However in OCT, there are used light waves instead of ultrasound waves, which allow an exact examination of the retinal cell layers.

All the examinations performed in this study are standardized procedures at the Institute of Ophthalmology of the University hospital of Zürich. No risks or harms are expected in relation with the planed examinations. No payment will be asked for the study related examinations. Neither for patients nor for their health insurances arise any additional costs related to the participation in this study.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
71

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
      • Zurich, Switzerland
        • University Hospital Zurich

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

4 years to 10 years (Child)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

80 children (girls and boys) at the age of 3-10 years without (40 children) or with (40 children) an ocular disease such as maculopathy, opticopathy or amblyopia will be included. Probands and patients are recruited from consultations at the eye clinic of the University hospital of Zürich. The ophthalmologic care is provided independently of the patient's decision whether to participate in the study or not. This decision is the own free will of the patient and his or her parents.

Description

Inclusion-Criteria:

  • Children at the age of 3-10 years old
  • Informed Consent
  • Patient group: reduced monocular visual acuity with maculopathy, opticopathy or amblyopia.
  • Proband group: no disease with influence on the colour vision, age-related normal visual acuity

Exclusion-Criteria:

  • High anomalies of refraction (myopia < -6D, hyperopia > +4D)
  • Status post eye surgery
  • Medication with suspected influence on the visual perception
  • Age below 3 years or beyond 10 years.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort

Group / Cohort

A group or subgroup of participants in an observational study that is assessed for biomedical or health outcomes.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
normal control
Other: only examination
patients
patients with optic or macular pathology or amblyopia

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Time Frame
Percentage of correct answers per child per test.
Time Frame: one test performed within 1 year
one test performed within 1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
University of Zurich

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Principal Investigator: Christina Gerth-Kahlert, MD, University Hospital Zurich, Division of Ophthalmology

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
January 1, 2015

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
August 1, 2018

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
November 1, 2018

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
March 30, 2015

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
June 2, 2015

First Posted (Estimate)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
June 8, 2015

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
November 26, 2018

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
November 22, 2018

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
November 1, 2018

More Information

Terms related to this study

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • KEK-ZH-Nr. 2014-0340

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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