Observational Study of Botulinum Toxin Type A in Patients With Urinary Incontinence Associated With Overactive Bladder (BOREAL)

October 21, 2016 updated by: Allergan
This study will describe the prescription conditions of botulinum toxin Type A (Botox®) injection for the treatment of urinary incontinence due to neurogenic detrusor overactivity (NDO) or idiopathic overactive bladder (IOAB) as per standard of care in clinical practice in France.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
474

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • AIX en Provence, France, 13616
        • Site D'Aix En Provence
      • Albi, France, 81000
        • CL Toulouse Lautrec
      • Angers Cedex 01, France, 49033
        • CHU Angers
      • Angouleme Cedex 9, France, 16959
        • CH Angouleme
      • Avranches, France, 50300
        • CH Avranches Granville
      • Bagnols-Sur-Ceze, France, 30200
        • CH Bagnols sur Ceze
      • Belfort Cedex, France, 90016
        • Ch Belfort
      • Besancon Cedex, France, 25030
        • CHU Besançon
      • Bordeaux, France, 33000
        • CL Saint Augustin
      • Bordeaux Cedex, France, 33076
        • CHU Bordeaux
      • Cahors, France, 46000
        • CH de Cahors
      • Chalons-En-Champagne, France, 51000
        • CH Châlons-en-Champagne
      • Clermont-Ferrand, France, 63003
        • Chu Clermont Ferrand
      • Colmar Cedex, France, 68024
        • CH Colmar
      • Creteil, France, 94010
        • CHU Mondor (APHP)
      • Cucq, France, 62780
        • CH Hopale Ctre Calot/Helio
      • Dijon Cedex, France, 21079
        • CHU Dijon
      • Epinal Cedex, France, 88021
        • CHI E.Durkheim Plateau de La Justice
      • Garches, France, 92380
        • CH Raymond Poincare (APHP)
      • Giens-Hyeres, France, 83406
        • CH Renee Sabran Hyeres (HCL)
      • La Rochelle, France, 17000
        • GH de la Rochelle Ré-Aunis
      • Le Kremlin-Bicetre, France, 94270
        • CH Bicêtre (APHP)
      • Le Mans Cedex 9, France, 72037
        • CH Le Mans
      • Limoges Cedex, France, 87042
        • CHU Limoges
      • Lorient, France, 56100
        • CL Mutualiste Porte de L'Orient
      • Marseille, France, 13005
        • CH de la Conception (APHM)
      • Mont de Marsan, France, 40000
        • CH Mont de Marsan
      • Montpellier, France, 34070
        • CL Beau Soleil
      • Montpellier, France, 34090
        • CHU Montpellier
      • Mulhouse, France, 68100
        • CH Mulhouse
      • Nimes, France, 30029
        • CHU Nîmes
      • Paris, France, 75014
        • GH Saint Joseph
      • Paris, France, 75020
        • CH Tenon (APHP)
      • Pierre-Benite Cedex, France, 69495
        • CH Lyon Sud (HCL)
      • Pointoise Cedex, France, 95301
        • CH de Pontoise
      • Poitiers Cedex, France, 86021
        • USLD de Lusignan
      • Pringy Cedex, France, 74374
        • CH Annecy
      • Privas, France, 07007
        • SIH Privas La Voulte
      • Reims, France, 51100
        • Polyclinique Les Bleuets
      • Rennes Cedex, France, 35033
        • CHU de Rennes
      • Rouen Cedex, France, 76031
        • CHU de Rouen
      • Saint Cyr/Loire, France, 37540
        • CL de L'Alliance Saint Cyr/Loire
      • Saint-Avold, France, 57500
        • CH Saint-Avold
      • Saint-Etienne, France, 42100
        • CL Mutualiste Chirurgicale
      • Saintes Cedex, France, 17108
        • CH de Saintonge (Saintes)
      • Strasbourg, France, 67000
        • Hopital Civil / Nouvel Hopital Civil
      • Suresnes, France, 92150
        • CH Foch
      • Tarbes, France, 65000
        • Clinique de l'Ormeau Pyrénées
      • Toulouse Cedex 9, France, 31059
        • CHU Toulouse
      • Tours Cedex 09, France, 37044
        • CHU Tours

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Adult patients treated with Botox® for urinary incontinence associated with NDO or IOAB in clinical practice.

Description

Inclusion Criteria:

-Patients who receive a Botox® injection for urinary incontinence.

Exclusion Criteria:

-Patients not residing in France.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Only
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort

Group / Cohort

A group or subgroup of participants in an observational study that is assessed for biomedical or health outcomes.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Botox®
Patients prescribed botulinum toxin Type A (Botox®) injection for the treatment of urinary incontinence associated with neurogenic detrusor overactivity or overactive bladder as per standard of care in clinical practice.
Biological: botulinum toxin Type A
Botulinum toxin Type A (Botox®) injection as prescribed as standard of care in clinical practice.
Other Names:
  • Botox®
  • onabotulinumtoxinA

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Time Frame
Target Patients Prescribed Botox® in Clinical Practice
Time Frame: Day 1
Day 1

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Time Frame
Treatments Previously Prescribed
Time Frame: Day 1
Day 1
Number of Sites Injected
Time Frame: Day 1
Day 1
Total Dose of Botox® Used
Time Frame: Day 1
Day 1
Types of Anaesthesia and Antibiotic Prophylaxis Used
Time Frame: Day 1
Day 1
Cytobacteriological Examination of the Urine
Time Frame: Day 1
Day 1
Total Number of Botox® Cycles in Non-naive Patients (previously received Botox®)
Time Frame: Day 1
Day 1
Length of Botox® Treatment in Non-naive Patients
Time Frame: Day 1
Day 1
Time Since Last Botox® Injection in Non-naive Patients
Time Frame: Day 1
Day 1
Characteristics of Injector Sites (Locations)
Time Frame: Day 1
Day 1
Characteristics of Injector Physicians
Time Frame: Day 1
Day 1
Characteristics of Patients
Time Frame: Day 1
Day 1
Number of Patients by Pathology History
Time Frame: Day 1
Day 1
Number of Patients by Medical and Surgical History
Time Frame: Day 1
Day 1
Reduction of Number of Daily Urinary Incontinence Episodes in Non-naive Patients
Time Frame: Day 1
Day 1
Percentage of Continent Patients in Non-naive Patients
Time Frame: Day 1
Day 1
Number of Adverse Events during the Visit
Time Frame: Day 1
Day 1

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Allergan

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
February 1, 2016

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
August 1, 2016

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
August 1, 2016

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
February 1, 2016

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
February 1, 2016

First Posted (Estimate)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
February 3, 2016

Study Record Updates

Last Update Posted (Estimate)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
October 24, 2016

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
October 21, 2016

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
October 1, 2016

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • MAF/AGN/NS/OAB/006

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Cookie Settings

We use cookies to ensure that we give you the best experience on our website. For more details carefully read our Privacy and Cookies Policy. ...>>>You can change your preferences or withdraw your consent at any time by deleting the cookies from your website or computer as described in the policy. Please accept it and choose your preferences by ticking the corresponding boxes in the "Manage Settings" section below. Please carefully read our Terms of Service before you proceed with using any part of this website.
«Manage Settings