Pulmonary Physiology and Systemic Inflammatory in EO Pulmonary Events with Brigatinib Use in NSCLC and Other Diseases

Inclusion Criteria:

1. Provision to sign and date the consent form, indicating that he or she has been informed of all pertinent aspects of the study, including the potential risks, and is willingly participating.
2. Stated willingness and ability to comply with all scheduled visits and study procedures, and be available for the duration of the study.
3. Be a male or female aged ≥ 18.
4. Must plan on receiving brigatinib at a starting dose of 90 mg QD, regardless of whether they are receiving brigatinib as a part of clinical trial (if they meet eligibility criteria for given clinical trial) or outside of clinical trial as part of standard of care cancer treatment per the FDA license.
5. Suitable for treatment with brigatinib per either FDA labels, an acceptable clinical indication or within brigatinib clinical trials.
6. Participants must plan on taking Brigatinib as the only systemic cancer treatment. This means that participants cannot be receiving other targeted therapies, chemotherapies, or immunotherapies while on brigatinib (Exceptions: nonimmunosuppressive supportive cancer therapies such as bone targeting agents [e.g., denosumab], and anti-emetics are allowed).
7. Must have Hemoglobin (Hb) of ≥10 g/dL.
8. Recovered from clinically relevant toxicities (in the opinion of the investigator) related to prior anticancer therapy to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE, v4.03) grade ≤2.
9. Have Eastern Cooperative Oncology Group (ECOG) performance status ≤2.
10. Must have clearly documented information of previously received systemic cancer treatments including chemotherapy, immunotherapy, small molecule tyrosine-kinase inhibitors (incl. ALK-targeted TKI) and stop date of most recent systemic therapy.

Exclusion Criteria:

1. Have baseline oxygen supplementation requirement (i.e., resting O2 sats on room air ≥ 90%).
2. Have history or presence of pulmonary interstitial disease or drug-related pneumonitis on CT imaging of chest performed within 28 days prior to starting brigatinib.
3. Have malabsorption syndrome or other GI illness that could affect oral absorption of the study drug in the opinion of the investigator.
4. Have had a blood transfusion within past 120 days.
5. Have received any small molecule inhibitors, including crizotinib, within 7 days of the first dose of Brigatinib (e.g., If first scheduled dose of brigatinib is on a Monday, May 1st, 2017 then last dose of the prior line of small molecule inhibitor must have been given BEFORE Monday, April 24, 2017).
6. Have received cytotoxic chemotherapy, investigational agents, or cytotoxic doses of radiation within 14 days of brigatinib, except SRS or stereotactic body radiosurgery to anatomic sites not involving lung tissue.
7. Have received immunotherapy within 28 days of first dose of brigatinib.
8. Be on corticosteroid within 48 hours prior to first dose of brigatinib.

9. Have uncontrolled, or active cardiac, pulmonary or hematologic disease that can affect interpretation of DLCO, specifically including, but not restricted to:

   1. Pulmonary interstitial disease or drug-related pneumonitis
   2. Symptomatic or poorly controlled congestive heart failure (CHF) within 6 months prior to first dose
   3. Symptomatic or poorly controlled pulmonary embolism within last 6 months
10. Have an ongoing or active infection. The requirement for intravenous (IV) antibiotics is considered active infection.
11. Have a known or suspected hypersensitivity to AP26113 or its excipients.
12. Have any condition or illness that, in the opinion of the investigator, would compromise participant safety or interfere with evaluation of the drug study.