Assessment of Progranulin and FAM19A5 Protein Blood Levels in Metabolic Syndrome (PROG-FAM)

Inclusion Criteria:

• written and informed consent of the participant to participate in the study;
• age 18-99;

• meeting at least three of the following five metabolic syndrome criteria:

  • waist circumference ≥80 cm in women and ≥94 cm in men;
  • serum triglycerides> 150 mg / dl (1.7 mmol / l) or treatment of hypertriglyceridemia;
  • HDL serum concentration <50 mg / dl (1.3 mmol / l) - in women and <40 mg / dl (1.0 mmol / l) - in men or treatment of this lipid disorder;
  • systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 85 mm Hg, or treatment of previously diagnosed hypertension;
  • fasting plasma glucose ≥100 mg / dl (5.6 mmol / l) or pharmacological treatment of type 2 diabetes.

Exclusion Criteria:

• secondary form obesity,
• substitution of progranulin or / and FAM19A5 protein,
• weight reduction above 5% of baseline body weight in the last 3 months preceding recruitment,
• liposuction and / or other fat reduction treatments,
• pacemaker, cardioverter / defibrillator,
• condition after stroke,
• Alzheimer's disease,
• fronto-temporal dementia,
• occurrence of other neurodegenerative diseases,
• occurrence of significant neurological disorders,
• occurrence of inflammatory autoimmune diseases,
• lysosomal storage diseases,
• clinically significant abnormal liver, kidney or thyroid function;
• acute or clinically significant inflammatory process in the respiratory, digestive, genitourinary tracts,
• connective tissue diseases or arthritis;
• active cancer,
• addiction to alcohol or drugs;
• pregnancy or childbirth during recruitment or 3 months before recruitment;
• current lactation or lactation within 3 months before recruitment;
• and / or any other condition which, according to researchers, would cause that participation would not be in the patient's best interest or could limit the credibility of the study