Id and Rd Maintenance Regimens After Induction of Remission in Multiple Myeloma.

Inclusion Criteria:

1. Adult male or female patients aged 18 years or older with a confirmed diagnosis of symptomatic diagnosed multiple myeloma. Patients who have previously received initial treatment (induction, transplantation and consolidation are considered to be the same as first-line treatment) and the efficacy assessment ≥VGPR after the initial therapy.
2. An informed consent form (ICF) has been signed. Considering the patient's condition, if the patient's signature is not conducive to the treatment of the disease, the legal guardian or the patient's immediate family will sign the informed consent;

3. Female patients of child-bearing potential should meet both of the following criteria:

   1. Take effective contraceptive measures during the study and for three months following the last dose;
   2. A negative serum pregnancy test at screening. Note: Women of childbearing potential include all the female who have started menstruating and are not post-menopausal and have not undergone surgical sterilization(eg, hysterectomy, double tubal ligation, bilateral oophorectomy). Postmenopause is defined as amenorrhea for more than 12 consecutive months due to unspecified reasons.
4. Male subjects(including those undergo vasectomy) agree to use condoms if sexually active with a female of child-bearing potential from the date of signing the informed consent. And no plan of pregnancy throughout the study and for three months following the last dose.
5. There are follow-up conditions. The patients known about the characteristics of the disease and voluntarily join the study program for treatment and follow-up.

6. Complete documentation of of the initial therapy is available.

   • Details of the state treatment and remission
   • cytogenetics at diagnosis
   • R-ISS staging at diagnosis
7. Eastern Cooperative Oncology Group Performance Status of 0 to 2.
8. Patient is willing and able to adhere to the study visit schedule and other protocol requirements including blood sampling and bone marrow aspiration.

9. Patients must meet the following clinical laboratory criteria at study entry:

   • Absolute neutrophil count (ANC) ≥ 1,000/mm3 without growth factor support. Platelet count ≥ 75,000/mm3. Platelet transfusions to help patients meet eligibility criteria are not allowed within 3 days before randomization.
   • Total bilirubin ≤ 1.5 x the upper limit of the normal range (ULN).
   • Alanine aminotransferase and aspartate aminotransferase ≤ 3 x ULN.
   • Calculated creatinine clearance ≥ 30 mL/min (using the Cockcroft-Gault equation.

Exclusion Criteria:

1. Multiple myeloma that has relapsed after initial therapy.
2. Radiotherapy or major surgery within 14 days before randomization.
3. Diagnosed or treated for another malignancy within 1 years before randomization or previous diagnosis with another malignancy with evidence of residual disease. Patients with nonmelanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection.
4. Infection requiring IV antibiotic therapy or other serious infection within 14 days before randomization.
5. Evidence of current uncontrolled cardiovascular conditions, including uncontrolled hypertension, uncontrolled cardiac arrhythmias, uncontrolled congestive heart failure, unstable angina.
6. Systemic treatment with strong CYP3A inducers(rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital) .
7. Ongoing or active infection, known human immunodeficiency virus positive, active hepatitis B or C infection.
8. Comorbid systemic illnesses or other severe concurrent disease that, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens (e.g., PN of any cause that is Grade 1 with pain or Grade 2 or higher).
9. Psychiatric illness/social situation that would limit compliance with study requirements.
10. Known allergy to any of the study medications, their analogues, or excipients in the various formulations of any agent.
11. Inability to swallow oral medication, inability or unwillingness to comply with the drug administration requirements, or GI procedure that could interfere with the oral absorption or tolerance of treatment.
12. Treatment with any investigational products within 30 days before randomization.
13. Female patient who is lactating and breastfeeding or has a positive serum pregnancy test during the Screening period.