Study of ILX651 in Patients With Inoperable Locally Advanced or Metastatic Melanoma

A Phase II Study of ILX651 Administered Intravenously Daily for Five Consecutive Days Once Every 3 Weeks in Patients With Inoperable Locally Advanced or Metastatic Melanoma.

This is a Phase II, non-randomized, open label study of ILX651 in patients with inoperable locally advanced or metastatic melanoma. Approximately 60 patients will be enrolled in this study that is expected to last 18 months. All patients will be treated with ILX651 administered IV daily for 5 consecutive days once every 21 days. The primary objective of this study is to determine the overall response rate for all patients who are treated with ILX651. The secondary objectives are to determine the progression free survival at 18 weeks, duration of response, time to tumor progression, survival, safety/tolerability of ILX651 and to evaluate the pharmacokinetic profile.

Study Overview

• Status: Completed
• Conditions: Melanoma
• Intervention / Treatment: Drug: ILX651

• Study Type: Interventional
• Phase: Phase 2

Contacts and Locations

Study Locations

• United States
  • Arizona
    • Scottsdale, Arizona, United States, 85285
      • Arizona Cancer Center at Scottsdale
    • Tucson, Arizona, United States, 85724
      • Univ of Arizona Cancer Center
  • California
    • Los Angeles, California, United States, 90033
      • USC / Norris Cancer Center
    • Santa Monica, California, United States, 90404
      • Cancer Institute Medical Group
  • Colorado
    • Aurora, Colorado, United States, 80010
      • Univ of Colorado Cancer Center/ Anschutz Cancer
  • Florida
    • Orlando, Florida, United States, 32806
      • US Oncology / Cancer Centers of Florida
  • Kansas
    • Overland Park, Kansas, United States, 66210
      • US Oncology / Kansas City Oncology
  • Massachusetts
    • Boston, Massachusetts, United States, 02215
      • Beth Israel Medical Center
  • Missouri
    • Kansas City, Missouri, United States, 64111
      • US Oncology / Kansas City Oncology and Hematology
    • St. Louis, Missouri, United States, 63141
      • Center for Cancer Care Research
  • New York
    • Albany, New York, United States, 12208
      • US Oncology / Albany Regional Cancer Center
  • Ohio
    • Kettering, Ohio, United States, 45409
      • US Oncology / Dayton Oncology and Hematology
  • South Carolina
    • Greenville, South Carolina, United States, 29615
      • US Oncology / Cancer Centers of the Carolinas
  • Texas
    • Dallas, Texas, United States, 75246
      • US Oncology / Mary Crowley Medical Research
    • Ft. Worth, Texas, United States, 76104
      • US Oncology /Texas Oncology
    • Houston, Texas, United States, 77030
      • St. Luke's Episcopal Hospital
    • Tyler, Texas, United States, 75702
      • US Oncology/ Tyler Cancer Center
  • Washington
    • Seattle, Washington, United States, 98109
      • Seattle Cancer Care Alliance
    • Spokane, Washington, United States, 99218
      • US Oncology / Cancer Care Northwest

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Histologically or cytologically confirmed inoperable locally advanced or metastatic malignant melanoma.
• Measurable disease. Measurable lesions should be outside the field of radiation. Where measurable lesions are within a previously irradiated field, there must be objective evidence of progression of the lesion prior to patient enrollment.
• Male or female patients greater than or equal to 18 years of age.
• ECOG performance status of 0 or 1.
• Must have adequate organ and immune system function as indicated by the following laboratory values, obtained less than or equal to 2 weeks prior to registration: A. Absolute neutrophil count(ANC) greater than or equal to 1.5 x 1,000,000,000. B.Hemoglobin greater than or equal to 9.0 g/Dl. C. Platelet count greater than or equal to 100 x 1,000,000,000/L. E. Serum creatinine or calculated creatinine clearance less than or equal to 1.5 mg/dL or greater than or equal to 60 mL/min. F. Serum total bilirubin less than or equal to 2.0 mg/dL. G. AST and ALT less than or equal to 3 times the upper limit of normal (ULN) OR less than 5 times the ULN if secondary to liver metastases. H. Alkaline phosphatase less than or equal to 5 times the ULN (unless bone metastases are present in the absence of liver metastases).
• Anti-cancer therapy, major surgery, or irradiation must have been completed at least 4 weeks before enrollment in this study. Patient must have recovered from the acute side effects incurred as a result of previous therapy.
• Female patients with childbearing potential must have a negative pregnancy test within 7 days of study enrollment. Men and women of reproductive potential must use an effective contraceptive method while enrolled in the study.
• Signed informed consent (includes HIPAA authorization).

Exclusion Criteria:

• Patients with uncontrolled congestive heart failure or angina, patients with a history of myocardial infarction within 2 months of enrollment, or patients with cardiac functional capacity Class III or IV as defined by the New York Heart Association Classification.
• Previously treated with systemic chemotherapy.
• Prior radiotherapy to the only site of measurable disease.
• Known hypersensitivity to study drug or its analogs.
• Active ocular melanoma. Patients with a primary diagnosis of ocular melanoma will not be excluded provided the primary ocular melanoma is no longer present and the recurrence is distal.
• Use of investigational agents within previous 30 days.
• Known, active infection, or known HIV positive or presence of an AIDS related illness.
• Active secondary malignancy.
• Presence of symptomatic active brain metastases, including leptomeningeal involvement. Prior evidence of brain metastasis is permitted only if the patient has been in clinical complete remission for at least 1 month after therapy.
• Uncontrolled hypertension. Patients with hypertension must have their blood pressure controlled on antihypertensive medications as assessed by the investigator.
• Patients with prior radiation therapy to greater than 25% of the bone marrow (eg, no whole pelvic irradiation is allowed).
• Any significant concurrent disease or illness, or psychiatric disorders or alcohol or chemical abuse that would, in the opinion of the investigator, compromise patient safety or compliance, or interfere with the interpretation of study results.
• Pregnant or lactating females.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Collaborators and Investigators

• Sponsor: Genzyme, a Sanofi Company

Study record dates

Study Major Dates

• Study Start: August 1, 2003
• Study Completion (Actual): January 1, 2006

Study Registration Dates

• First Submitted: September 9, 2003
• First Submitted That Met QC Criteria: September 10, 2003
• First Posted (Estimate): September 11, 2003

Study Record Updates

• Last Update Posted (Estimate): March 5, 2015
• Last Update Submitted That Met QC Criteria: March 4, 2015
• Last Verified: March 1, 2015

More Information

Terms related to this study

• Keywords: Melanoma; Metastatic Melanoma; Inoperable Locally Advanced Melanoma
• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue; Neuroendocrine Tumors; Nevi and Melanomas; Melanoma
• Other Study ID Numbers: ILX651-211